Role of LINGO1 polymorphisms in Parkinson's disease
Identifieur interne : 002064 ( Main/Exploration ); précédent : 002063; suivant : 002065Role of LINGO1 polymorphisms in Parkinson's disease
Auteurs : Dietrich Haubenberger [Autriche] ; Christoph Hotzy [Autriche] ; Walter Pirker [Autriche] ; Regina Katzenschlager [Autriche] ; Thomas Brücke [Autriche] ; Fritz Zimprich [Autriche] ; Eduard Auff [Autriche] ; Alexander Zimprich [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Autriche.
English descriptors
- KwdEn :
- Aged, Austria, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, LINGO1, Male, Membrane Proteins (genetics), Middle Aged, Nerve Tissue Proteins (genetics), Nervous system diseases, Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Single Nucleotide (genetics), Tremor, association study, essential tremor, genetics.
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- geographic : Austria.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged.
Abstract
A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/71D32E42B6840DD8E45FC346572B803620242F58/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798904
DOI: 10.1002/mds.22768
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="fr">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society</div>
</front>
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<name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
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