MovDisordV3, PascalFrancis, Corpus, bibRecord, 000C72

Role of LINGO Polymorphisms in Parkinson's Disease

Identifieur interne : 000C72 ( PascalFrancis/Corpus ); précédent : 000C71; suivant : 000C73

Role of LINGO Polymorphisms in Parkinson's Disease

Auteurs : Dietrich Haubenberger ; Christoph Hotzy ; Walter Pirker ; Regina Katzenschlager ; Thomas Brücke ; Fritz Zimprich ; Eduard Auff ; Alexander Zimprich

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:10-0071242

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Tremblement, Pathologie du système nerveux, Polymorphisme.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Polymorphism, Tremor.

Abstract

A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 24`
A06				`@2 16`
A08	`01`	`1`	`ENG`	`@1 Role of LINGO Polymorphisms in Parkinson's Disease`
A11	`01`	`1`		`@1 HAUBENBERGER (Dietrich)`
A11	`02`	`1`		`@1 HOTZY (Christoph)`
A11	`03`	`1`		`@1 PIRKER (Walter)`
A11	`04`	`1`		`@1 KATZENSCHLAGER (Regina)`
A11	`05`	`1`		`@1 BRÜCKE (Thomas)`
A11	`06`	`1`		`@1 ZIMPRICH (Fritz)`
A11	`07`	`1`		`@1 AUFF (Eduard)`
A11	`08`	`1`		`@1 ZIMPRICH (Alexander)`
A14	`01`			`@1 Department of Neurology, Medical University of Vienna @2 Vienna @3 AUT @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A14	`02`			`@1 Department of Neurology, SMZ-Ost Donauspital @2 Vienna @3 AUT @Z 4 aut.`
A14	`03`			`@1 Department of Neurology @2 Wilhelminenspital, Vienna @3 AUT @Z 5 aut.`
A20				`@1 2404-2407`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000190005540140`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 10-0071242`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Tremblement @5 02`
C03	`02`	`X`	`ENG`	`@0 Tremor @5 02`
C03	`02`	`X`	`SPA`	`@0 Temblor @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Polymorphisme @5 09`
C03	`04`	`X`	`ENG`	`@0 Polymorphism @5 09`
C03	`04`	`X`	`SPA`	`@0 Polimorfismo @5 09`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Mouvement involontaire @5 42`
C07	`05`	`X`	`ENG`	`@0 Involuntary movement @5 42`
C07	`05`	`X`	`SPA`	`@0 Movimiento involuntario @5 42`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 43`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
N21				`@1 046`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0071242 INIST
ET :	Role of LINGO Polymorphisms in Parkinson's Disease
AU :	HAUBENBERGER (Dietrich); HOTZY (Christoph); PIRKER (Walter); KATZENSCHLAGER (Regina); BRÜCKE (Thomas); ZIMPRICH (Fritz); AUFF (Eduard); ZIMPRICH (Alexander)
AF :	Department of Neurology, Medical University of Vienna/Vienna/Autriche (1 aut., 2 aut., 3 aut., 6 aut., 7 aut., 8 aut.); Department of Neurology, SMZ-Ost Donauspital/Vienna/Autriche (4 aut.); Department of Neurology/Wilhelminenspital, Vienna/Autriche (5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 16; Pp. 2404-2407; Bibl. 15 ref.
LA :	Anglais
EA :	A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Tremblement; Pathologie du système nerveux; Polymorphisme
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Mouvement involontaire; Trouble neurologique
ED :	Parkinson disease; Tremor; Nervous system diseases; Polymorphism
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder
SD :	Parkinson enfermedad; Temblor; Sistema nervioso patología; Polimorfismo
LO :	INIST-20953.354000190005540140
ID :	10-0071242

Links to Exploration step

Pascal:10-0071242

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Role of LINGO Polymorphisms in Parkinson's Disease</title>
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<front><div type="abstract" xml:lang="en">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</div>
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<fC01 i1="01" l="ENG"><s0>A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</s0>
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<s5>01</s5>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Tremblement</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Tremor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Temblor</s0>
<s5>02</s5>
</fC03>
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<s5>03</s5>
</fC03>
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</fC03>
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<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Polymorphisme</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Polymorphism</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Polimorfismo</s0>
<s5>09</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>43</s5>
</fC07>
<fN21><s1>046</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 10-0071242 INIST</NO>
<ET>Role of LINGO Polymorphisms in Parkinson's Disease</ET>
<AU>HAUBENBERGER (Dietrich); HOTZY (Christoph); PIRKER (Walter); KATZENSCHLAGER (Regina); BRÜCKE (Thomas); ZIMPRICH (Fritz); AUFF (Eduard); ZIMPRICH (Alexander)</AU>
<AF>Department of Neurology, Medical University of Vienna/Vienna/Autriche (1 aut., 2 aut., 3 aut., 6 aut., 7 aut., 8 aut.); Department of Neurology, SMZ-Ost Donauspital/Vienna/Autriche (4 aut.); Department of Neurology/Wilhelminenspital, Vienna/Autriche (5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 16; Pp. 2404-2407; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Tremblement; Pathologie du   système nerveux; Polymorphisme</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Mouvement involontaire; Trouble neurologique</FG>
<ED>Parkinson disease; Tremor; Nervous system diseases; Polymorphism</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Involuntary movement; Neurological disorder</EG>
<SD>Parkinson enfermedad; Temblor; Sistema nervioso patología; Polimorfismo</SD>
<LO>INIST-20953.354000190005540140</LO>
<ID>10-0071242</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Role of LINGO Polymorphisms in Parkinson's Disease

Role of LINGO Polymorphisms in Parkinson's Disease

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