Role of LINGO1 polymorphisms in Parkinson’s disease
Identifieur interne : 002887 ( Ncbi/Merge ); précédent : 002886; suivant : 002888Role of LINGO1 polymorphisms in Parkinson’s disease
Auteurs : Dietrich Haubenberger [Autriche] ; Christoph Hotzy [Autriche] ; Walter Pirker [Autriche] ; Regina Katzenschlager [Autriche] ; Thomas Brücke [Autriche] ; Fritz Zimprich [Autriche] ; Eduard Auff [Autriche] ; Alexander Zimprich [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2009.
Descripteurs français
- Wicri :
- geographic : Autriche.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- geographic : Austria.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged.
Abstract
A clinical overlap between Parkinson’s disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this present study, SNPs rs9652490, rs11856808, rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant PD patients reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.
Url:
DOI: 10.1002/mds.22768
PubMed: 19908305
PubMed Central: 2798904
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Hotzy</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Katzenschlager, Regina" 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sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 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xml:lang="fr"><term>Autriche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A clinical overlap between Parkinson’s disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this present study, SNPs rs9652490, rs11856808, rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant PD patients reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</p></div></front></TEI><double pmid="19908305"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of LINGO1 polymorphisms in Parkinson’s disease</title><author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Hotzy, Christoph" sort="Hotzy, Christoph" uniqKey="Hotzy C" first="Christoph" last="Hotzy">Christoph Hotzy</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna</wicri:regionArea><wicri:noRegion>A-1220 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna</wicri:regionArea><wicri:noRegion>A-1160 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19908305</idno><idno type="pmc">2798904</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798904</idno><idno type="RBID">PMC:2798904</idno><idno type="doi">10.1002/mds.22768</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000072</idno><idno type="wicri:Area/Pmc/Curation">000072</idno><idno type="wicri:Area/Pmc/Checkpoint">000393</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of LINGO1 polymorphisms in Parkinson’s disease</title><author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Hotzy, Christoph" sort="Hotzy, Christoph" uniqKey="Hotzy C" first="Christoph" last="Hotzy">Christoph Hotzy</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna</wicri:regionArea><wicri:noRegion>A-1220 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna</wicri:regionArea><wicri:noRegion>A-1160 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea><wicri:noRegion>A-1090 Vienna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A clinical overlap between Parkinson’s disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this present study, SNPs rs9652490, rs11856808, rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant PD patients reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of LINGO1 polymorphisms in Parkinson's disease.</title><author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Medical University of Vienna, Vienna, Austria. dietrich.haubenberger@meduniwien.ac.at</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Hotzy, Christoph" sort="Hotzy, Christoph" uniqKey="Hotzy C" first="Christoph" last="Hotzy">Christoph Hotzy</name></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name></author><author><name sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name></author><author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22768</idno><idno type="RBID">pubmed:19908305</idno><idno type="pmid">19908305</idno><idno type="wicri:Area/PubMed/Corpus">001A96</idno><idno type="wicri:Area/PubMed/Curation">001A96</idno><idno type="wicri:Area/PubMed/Checkpoint">001B78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of LINGO1 polymorphisms in Parkinson's disease.</title><author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Medical University of Vienna, Vienna, Austria. dietrich.haubenberger@meduniwien.ac.at</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Hotzy, Christoph" sort="Hotzy, Christoph" uniqKey="Hotzy C" first="Christoph" last="Hotzy">Christoph Hotzy</name></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name></author><author><name sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name></author><author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Austria</term><term>Female</term><term>Gene Frequency</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Membrane Proteins (genetics)</term><term>Middle Aged</term><term>Nerve Tissue Proteins (genetics)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Austria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Gene Frequency</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Autriche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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