Role of LINGO1 polymorphisms in Parkinson's disease.
Identifieur interne : 001B78 ( PubMed/Checkpoint ); précédent : 001B77; suivant : 001B79Role of LINGO1 polymorphisms in Parkinson's disease.
Auteurs : Dietrich Haubenberger [Autriche] ; Christoph Hotzy ; Walter Pirker ; Regina Katzenschlager ; Thomas Brücke ; Fritz Zimprich ; Eduard Auff ; Alexander ZimprichSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
Descripteurs français
- Wicri :
- geographic : Autriche.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- geographic : Austria.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged.
Abstract
A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.
DOI: 10.1002/mds.22768
PubMed: 19908305
Affiliations:
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pubmed:19908305Le document en format XML
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<front><div type="abstract" xml:lang="en">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</div>
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<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2008 May 15;23(7):993-7</RefSource>
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<PMID Version="1">19289477</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2004 Aug;10(6):357-62</RefSource>
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<PMID Version="1">16939701</PMID>
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