Role of LINGO1 polymorphisms in Parkinson's disease
Identifieur interne : 002925 ( Main/Merge ); précédent : 002924; suivant : 002926Role of LINGO1 polymorphisms in Parkinson's disease
Auteurs : Dietrich Haubenberger [Autriche] ; Christoph Hotzy [Autriche] ; Walter Pirker [Autriche] ; Regina Katzenschlager [Autriche] ; Thomas Brücke [Autriche] ; Fritz Zimprich [Autriche] ; Eduard Auff [Autriche] ; Alexander Zimprich [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
Descripteurs français
- Wicri :
- geographic : Autriche.
English descriptors
- KwdEn :
- Aged, Austria, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, LINGO1, Male, Membrane Proteins (genetics), Middle Aged, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Parkinson's disease, Polymorphism, Single Nucleotide (genetics), association study, essential tremor, genetics.
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- geographic : Austria.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged.
Abstract
A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/71D32E42B6840DD8E45FC346572B803620242F58/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798904
DOI: 10.1002/mds.22768
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<front><div type="abstract" xml:lang="fr">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="fr">A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome‐wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor‐dominant patients with PD reveal a significant association. This study on LINGO1‐variants in PD argues against a major role of LINGO1 gene variations for PD. © 2009 Movement Disorder Society</div>
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<author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna</wicri:regionArea>
<wicri:noRegion>A-1220 Vienna</wicri:noRegion>
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<author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
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<wicri:regionArea>Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna</wicri:regionArea>
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<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
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<author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
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<idno type="doi">10.1002/mds.22768</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of LINGO1 polymorphisms in Parkinson’s disease</title>
<author><name sortKey="Haubenberger, Dietrich" sort="Haubenberger, Dietrich" uniqKey="Haubenberger D" first="Dietrich" last="Haubenberger">Dietrich Haubenberger</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hotzy, Christoph" sort="Hotzy, Christoph" uniqKey="Hotzy C" first="Christoph" last="Hotzy">Christoph Hotzy</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, SMZ-Ost Donauspital, Langobardenstr. 122, A-1220 Vienna</wicri:regionArea>
<wicri:noRegion>A-1220 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Wilhelminenspital, Montleartstr. 37, A-1160 Vienna</wicri:regionArea>
<wicri:noRegion>A-1160 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zimprich, Fritz" sort="Zimprich, Fritz" uniqKey="Zimprich F" first="Fritz" last="Zimprich">Fritz Zimprich</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Auff, Eduard" sort="Auff, Eduard" uniqKey="Auff E" first="Eduard" last="Auff">Eduard Auff</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Austria</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Proteins (genetics)</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term>
<term>Nerve Tissue Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Austria</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Autriche</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">A clinical overlap between Parkinson’s disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this present study, SNPs rs9652490, rs11856808, rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant PD patients reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.</p>
</div>
</front>
</TEI>
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