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Movement Disorders (revue)

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Role of LINGO1 polymorphisms in Parkinson’s disease

Identifieur interne : 000072 ( Pmc/Corpus ); précédent : 000071; suivant : 000073

Role of LINGO1 polymorphisms in Parkinson’s disease

Auteurs : Dietrich Haubenberger ; Christoph Hotzy ; Walter Pirker ; Regina Katzenschlager ; Thomas Brücke ; Fritz Zimprich ; Eduard Auff ; Alexander Zimprich

Source :

RBID : PMC:2798904

Abstract

A clinical overlap between Parkinson’s disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this present study, SNPs rs9652490, rs11856808, rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant PD patients reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.


Url:
DOI: 10.1002/mds.22768
PubMed: 19908305
PubMed Central: 2798904

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