MovDisordV3, Main, Exploration, bibRecord, 002D60

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Identifieur interne : 002D60 ( Main/Exploration ); précédent : 002D59; suivant : 002D61

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi [Italie] ; Emanuele Persichetti [Italie] ; Lucilla Parnetti [Italie] ; Michele Sbaragli [Italie] ; Carmelo Tassi [Italie] ; Aldo Orlacchio [Italie] ; Paolo Calabresi [Italie] ; Tommaso Beccari [Italie] ; Aroldo Rossi [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-07-30.

RBID : ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058

Descripteurs français

Pascal (Inist)
- Homme, Hydrolases, Liquide céphalorachidien, Parkinson maladie, Système nerveux pathologie, α-Mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Cerebrospinal fluid, Chromatography, Ion Exchange (methods), Female, Human, Humans, Hyaluronoglucosaminidase (cerebrospinal fluid), Hydrolases, Male, Middle Aged, Nervous system diseases, Parkinson Disease (cerebrospinal fluid), Parkinson disease, Parkinson's disease, Statistics, Nonparametric, α-Mannosidase, α‐mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase, β‐glucocerebrosidase, β‐hexosaminidase, β‐mannosidase.
MESH :
- chemical , cerebrospinal fluid : Hyaluronoglucosaminidase.
- cerebrospinal fluid : Parkinson Disease.
- methods : Chromatography, Ion Exchange.
- Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/pdf

DOI: 10.1002/mds.21399

Affiliations:

Le document en format XML

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<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
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<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
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<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
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<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
</author>
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<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
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<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
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<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Hyaluronoglucosaminidase (cerebrospinal fluid)</term>
<term>Hydrolases</term>
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<term>Nervous system diseases</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
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<term>β‐glucocerebrosidase</term>
<term>β‐hexosaminidase</term>
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div>
</front>
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<name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
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<name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
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<name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
<name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
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Movement Disorders (revue)

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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