Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.
Identifieur interne : 001C85 ( Ncbi/Merge ); précédent : 001C84; suivant : 001C86Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.
Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi ; Emanuele Persichetti ; Lucilla Parnetti ; Michele Sbaragli ; Carmelo Tassi ; Aldo Orlacchio ; Paolo Calabresi ; Tommaso Beccari ; Aroldo RossiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , cerebrospinal fluid : Hyaluronoglucosaminidase.
- cerebrospinal fluid : Parkinson Disease.
- methods : Chromatography, Ion Exchange.
- Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
DOI: 10.1002/mds.21399
PubMed: 17546678
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- to stream PubMed, to step Corpus: 002654
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pubmed:17546678Le document en format XML
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<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
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<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
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<term>Hyaluronoglucosaminidase (cerebrospinal fluid)</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Statistics, Nonparametric</term>
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<term>Humans</term>
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<term>Statistics, Nonparametric</term>
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div>
</front>
</TEI>
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<ArticleTitle>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.</ArticleTitle>
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<Abstract><AbstractText>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</AbstractText>
<CopyrightInformation>Copyright 2007 Movement Disorder Society</CopyrightInformation>
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