Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Identifieur interne : 004193 ( Main/Merge ); précédent : 004192; suivant : 004194Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi [Italie] ; Emanuele Persichetti [Italie] ; Lucilla Parnetti [Italie] ; Michele Sbaragli [Italie] ; Carmelo Tassi [Italie] ; Aldo Orlacchio [Italie] ; Paolo Calabresi [Italie] ; Tommaso Beccari [Italie] ; Aroldo Rossi [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
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- topic : Homme.
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Abstract
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
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Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondazione Santa Lucia, IRCCS</s1><s2>Roma</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Rossi, 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type="wicri:Area/Main/Merge">004193</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondazione Santa Lucia, IRCCS</s1><s2>Roma</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondazione Santa Lucia, IRCCS</s1><s2>Roma</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrospinal fluid</term><term>Human</term><term>Hydrolases</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>α-Mannosidase</term><term>β-Mannosidase</term><term>β-N-Acetylhexosaminidase</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Hydrolases</term><term>Liquide céphalorachidien</term><term>Homme</term><term>α-Mannosidase</term><term>β-Mannosidase</term><term>β-N-Acetylhexosaminidase</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name></noRegion><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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