Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Identifieur interne : 003C82 ( Main/Merge ); précédent : 003C81; suivant : 003C83Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi [Italie] ; Emanuele Persichetti [Italie] ; Lucilla Parnetti [Italie] ; Michele Sbaragli [Italie] ; Carmelo Tassi [Italie] ; Aldo Orlacchio [Italie] ; Paolo Calabresi [Italie] ; Tommaso Beccari [Italie] ; Aroldo Rossi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
English descriptors
- KwdEn :
- MESH :
- chemical , cerebrospinal fluid : Hyaluronoglucosaminidase.
- cerebrospinal fluid : Parkinson Disease.
- methods : Chromatography, Ion Exchange.
- Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21399
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003127
- to stream Istex, to step Curation: 003127
- to stream Istex, to step Checkpoint: 001868
- to stream PubMed, to step Corpus: 002654
- to stream PubMed, to step Curation: 002654
- to stream PubMed, to step Checkpoint: 002732
- to stream Ncbi, to step Merge: 001C85
- to stream Ncbi, to step Curation: 001C85
- to stream Ncbi, to step Checkpoint: 001C85
Links to Exploration step
ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21399</idno>
<idno type="url">https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003127</idno>
<idno type="wicri:Area/Istex/Curation">003127</idno>
<idno type="wicri:Area/Istex/Checkpoint">001868</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Balducci C:lysosomal:hydrolases:in</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:17546678</idno>
<idno type="wicri:Area/PubMed/Corpus">002654</idno>
<idno type="wicri:Area/PubMed/Curation">002654</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002732</idno>
<idno type="wicri:Area/Ncbi/Merge">001C85</idno>
<idno type="wicri:Area/Ncbi/Curation">001C85</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C85</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Balducci C:lysosomal:hydrolases:in</idno>
<idno type="wicri:Area/Main/Merge">003C82</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Santa Lucia, IRCCS, Roma</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Santa Lucia, IRCCS, Roma</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-07-30">2007-07-30</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1481">1481</biblScope>
<biblScope unit="page" to="1484">1484</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">AE0D8221BED66F75366B199F2FD3D66647D24058</idno>
<idno type="DOI">10.1002/mds.21399</idno>
<idno type="ArticleID">MDS21399</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Chromatography, Ion Exchange (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Hyaluronoglucosaminidase (cerebrospinal fluid)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson's disease</term>
<term>Statistics, Nonparametric</term>
<term>α‐mannosidase</term>
<term>β‐glucocerebrosidase</term>
<term>β‐hexosaminidase</term>
<term>β‐mannosidase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Hyaluronoglucosaminidase</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Ion Exchange</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.21399"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21399</idno>
<idno type="url">https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003127</idno>
<idno type="wicri:Area/Istex/Curation">003127</idno>
<idno type="wicri:Area/Istex/Checkpoint">001868</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Balducci C:lysosomal:hydrolases:in</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Santa Lucia, IRCCS, Roma</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Santa Lucia, IRCCS, Roma</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-07-30">2007-07-30</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1481">1481</biblScope>
<biblScope unit="page" to="1484">1484</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">AE0D8221BED66F75366B199F2FD3D66647D24058</idno>
<idno type="DOI">10.1002/mds.21399</idno>
<idno type="ArticleID">MDS21399</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>α‐mannosidase</term>
<term>β‐glucocerebrosidase</term>
<term>β‐hexosaminidase</term>
<term>β‐mannosidase</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21399</idno>
<idno type="RBID">pubmed:17546678</idno>
<idno type="pmid">17546678</idno>
<idno type="wicri:Area/PubMed/Corpus">002654</idno>
<idno type="wicri:Area/PubMed/Curation">002654</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002732</idno>
<idno type="wicri:Area/Ncbi/Merge">001C85</idno>
<idno type="wicri:Area/Ncbi/Curation">001C85</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C85</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Balducci C:lysosomal:hydrolases:in</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease.</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
<affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
</author>
<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
</author>
<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
</author>
<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
</author>
<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
</author>
<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Chromatography, Ion Exchange (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Hyaluronoglucosaminidase (cerebrospinal fluid)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Hyaluronoglucosaminidase</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Ion Exchange</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003C82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058 |texte= Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |