MovDisordV3, PascalFrancis, Corpus, bibRecord, 001585

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Identifieur interne : 001585 ( PascalFrancis/Corpus ); précédent : 001584; suivant : 001586

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Auteurs : Chiara Balducci ; Laura Pierguidi ; Emanuele Persichetti ; Lucilla Parnetti ; Michele Sbaragli ; Carmelo Tassi ; Aldo Orlacchio ; Paolo Calabresi ; Tommaso Beccari ; Aroldo Rossi

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393271

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Hydrolases, Liquide céphalorachidien, Homme, α-Mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase.

English descriptors

KwdEn :
- Cerebrospinal fluid, Human, Hydrolases, Nervous system diseases, Parkinson disease, α-Mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase.

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 BALDUCCI (Chiara)`
A11	`02`	`1`		`@1 PIERGUIDI (Laura)`
A11	`03`	`1`		`@1 PERSICHETTI (Emanuele)`
A11	`04`	`1`		`@1 PARNETTI (Lucilla)`
A11	`05`	`1`		`@1 SBARAGLI (Michele)`
A11	`06`	`1`		`@1 TASSI (Carmelo)`
A11	`07`	`1`		`@1 ORLACCHIO (Aldo)`
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A14	`03`			`@1 Fondazione Santa Lucia, IRCCS @2 Roma @3 ITA @Z 2 aut. @Z 8 aut.`
A14	`04`			`@1 Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia @2 Perugia @3 ITA @Z 6 aut. @Z 7 aut.`
A20				`@1 1481-1484`
A21				`@1 2007`
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A43	`01`			`@1 INIST @2 20953 @5 354000161473330170`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
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C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinson maladie @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinson disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson enfermedad @5 02`
C03	`03`	`X`	`FRE`	`@0 Hydrolases @2 FE @5 09`
C03	`03`	`X`	`ENG`	`@0 Hydrolases @2 FE @5 09`
C03	`03`	`X`	`SPA`	`@0 Hydrolases @2 FE @5 09`
C03	`04`	`X`	`FRE`	`@0 Liquide céphalorachidien @5 10`
C03	`04`	`X`	`ENG`	`@0 Cerebrospinal fluid @5 10`
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C03	`05`	`X`	`ENG`	`@0 Human @5 11`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 11`
C03	`06`	`X`	`FRE`	`@0 α-Mannosidase @2 FE @5 12 @6 «α»-Mannosidase`
C03	`06`	`X`	`ENG`	`@0 α-Mannosidase @2 FE @5 12 @6 «α»-Mannosidase`
C03	`06`	`X`	`SPA`	`@0 α-Mannosidase @2 FE @5 12 @6 «α»-Mannosidase`
C03	`07`	`X`	`FRE`	`@0 β-Mannosidase @2 FE @5 13 @6 «β»-Mannosidase`
C03	`07`	`X`	`ENG`	`@0 β-Mannosidase @2 FE @5 13 @6 «β»-Mannosidase`
C03	`07`	`X`	`SPA`	`@0 β-Mannosidase @2 FE @5 13 @6 «β»-Mannosidase`
C03	`08`	`X`	`FRE`	`@0 β-N-Acetylhexosaminidase @2 FE @5 14 @6 «β-N»-Acetylhexosaminidase`
C03	`08`	`X`	`ENG`	`@0 β-N-Acetylhexosaminidase @2 FE @5 14 @6 «β-N»-Acetylhexosaminidase`
C03	`08`	`X`	`SPA`	`@0 β-N-Acetylhexosaminidase @2 FE @5 14 @6 «β-N»-Acetylhexosaminidase`
C07	`01`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`01`	`X`	`ENG`	`@0 Enzyme @2 FE`
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C07	`02`	`X`	`ENG`	`@0 O-Glycosidases @2 FE @6 «O»-Glycosidases`
C07	`02`	`X`	`SPA`	`@0 O-Glycosidases @2 FE @6 «O»-Glycosidases`
C07	`03`	`X`	`FRE`	`@0 Glycosidases @2 FE`
C07	`03`	`X`	`ENG`	`@0 Glycosidases @2 FE`
C07	`03`	`X`	`SPA`	`@0 Glycosidases @2 FE`
C07	`04`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`04`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`04`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`05`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`05`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`05`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`06`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`06`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`06`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`07`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
C07	`07`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
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N21				`@1 253`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0393271 INIST
ET :	Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
AU :	BALDUCCI (Chiara); PIERGUIDI (Laura); PERSICHETTI (Emanuele); PARNETTI (Lucilla); SBARAGLI (Michele); TASSI (Carmelo); ORLACCHIO (Aldo); CALABRESI (Paolo); BECCARI (Tommaso); ROSSI (Aroldo)
AF :	Dipartimento di Medicina Interna, Università degli Studi di Perugia/Perugia/Italie (1 aut., 3 aut., 5 aut., 9 aut.); Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia/Perugia/Italie (2 aut., 4 aut., 8 aut., 10 aut.); Fondazione Santa Lucia, IRCCS/Roma/Italie (2 aut., 8 aut.); Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia/Perugia/Italie (6 aut., 7 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1481-1484; Bibl. 15 ref.
LA :	Anglais
EA :	Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Hydrolases; Liquide céphalorachidien; Homme; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase
FG :	Enzyme; O-Glycosidases; Glycosidases; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Hydrolases; Cerebrospinal fluid; Human; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase
EG :	Enzyme; O-Glycosidases; Glycosidases; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Hydrolases; Líquido cefalorraquídeo; Hombre; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase
LO :	INIST-20953.354000161473330170
ID :	07-0393271

Links to Exploration step

Pascal:07-0393271

Le document en format XML

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<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
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<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
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<s3>ITA</s3>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title>
<author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
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<author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
<affiliation><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1>
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<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<affiliation><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
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<author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
<affiliation><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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<sZ>5 aut.</sZ>
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<author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
<affiliation><inist:fA14 i1="04"><s1>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia</s1>
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</inist:fA14>
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<author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
<affiliation><inist:fA14 i1="04"><s1>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<affiliation><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Fondazione Santa Lucia, IRCCS</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
<affiliation><inist:fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
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</author>
<author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
<affiliation><inist:fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
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</affiliation>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrospinal fluid</term>
<term>Human</term>
<term>Hydrolases</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>α-Mannosidase</term>
<term>β-Mannosidase</term>
<term>β-N-Acetylhexosaminidase</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Hydrolases</term>
<term>Liquide céphalorachidien</term>
<term>Homme</term>
<term>α-Mannosidase</term>
<term>β-Mannosidase</term>
<term>β-N-Acetylhexosaminidase</term>
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div>
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<fA11 i1="07" i2="1"><s1>ORLACCHIO (Aldo)</s1>
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<fA11 i1="09" i2="1"><s1>BECCARI (Tommaso)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>ROSSI (Aroldo)</s1>
</fA11>
<fA14 i1="01"><s1>Dipartimento di Medicina Interna, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Fondazione Santa Lucia, IRCCS</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia</s1>
<s2>Perugia</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
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</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
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</fA45>
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<fC01 i1="01" l="ENG"><s0>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Liquide céphalorachidien</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Cerebrospinal fluid</s0>
<s5>10</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Líquido cefalorraquídeo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>11</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>α-Mannosidase</s0>
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<fC03 i1="06" i2="X" l="ENG"><s0>α-Mannosidase</s0>
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<fC03 i1="06" i2="X" l="SPA"><s0>α-Mannosidase</s0>
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<s5>12</s5>
<s6>«α»-Mannosidase</s6>
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<fC03 i1="07" i2="X" l="FRE"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
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<fC07 i1="02" i2="X" l="ENG"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
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<s5>40</s5>
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<s5>40</s5>
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<server><NO>PASCAL 07-0393271 INIST</NO>
<ET>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</ET>
<AU>BALDUCCI (Chiara); PIERGUIDI (Laura); PERSICHETTI (Emanuele); PARNETTI (Lucilla); SBARAGLI (Michele); TASSI (Carmelo); ORLACCHIO (Aldo); CALABRESI (Paolo); BECCARI (Tommaso); ROSSI (Aroldo)</AU>
<AF>Dipartimento di Medicina Interna, Università degli Studi di Perugia/Perugia/Italie (1 aut., 3 aut., 5 aut., 9 aut.); Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia/Perugia/Italie (2 aut., 4 aut., 8 aut., 10 aut.); Fondazione Santa Lucia, IRCCS/Roma/Italie (2 aut., 8 aut.); Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia/Perugia/Italie (6 aut., 7 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 10; Pp. 1481-1484; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Hydrolases; Liquide céphalorachidien; Homme; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase</FD>
<FG>Enzyme; O-Glycosidases; Glycosidases; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Hydrolases; Cerebrospinal fluid; Human; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase</ED>
<EG>Enzyme; O-Glycosidases; Glycosidases; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Hydrolases; Líquido cefalorraquídeo; Hombre; α-Mannosidase; β-Mannosidase; β-N-Acetylhexosaminidase</SD>
<LO>INIST-20953.354000161473330170</LO>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

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