Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Identifieur interne : 002D60 ( Main/Curation ); précédent : 002D59; suivant : 002D61Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi [Italie] ; Emanuele Persichetti [Italie] ; Lucilla Parnetti [Italie] ; Michele Sbaragli [Italie] ; Carmelo Tassi [Italie] ; Aldo Orlacchio [Italie] ; Paolo Calabresi [Italie] ; Tommaso Beccari [Italie] ; Aroldo Rossi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cerebrospinal fluid, Chromatography, Ion Exchange (methods), Female, Human, Humans, Hyaluronoglucosaminidase (cerebrospinal fluid), Hydrolases, Male, Middle Aged, Nervous system diseases, Parkinson Disease (cerebrospinal fluid), Parkinson disease, Parkinson's disease, Statistics, Nonparametric, α-Mannosidase, α‐mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase, β‐glucocerebrosidase, β‐hexosaminidase, β‐mannosidase.
- MESH :
- chemical , cerebrospinal fluid : Hyaluronoglucosaminidase.
- cerebrospinal fluid : Parkinson Disease.
- methods : Chromatography, Ion Exchange.
- Aged, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21399
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div>
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<author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
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<term>Female</term>
<term>Humans</term>
<term>Hyaluronoglucosaminidase (cerebrospinal fluid)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson's disease</term>
<term>Statistics, Nonparametric</term>
<term>α‐mannosidase</term>
<term>β‐glucocerebrosidase</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
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<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div>
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