Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Identifieur interne : 003127 ( Istex/Corpus ); précédent : 003126; suivant : 003128Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Auteurs : Chiara Balducci ; Laura Pierguidi ; Emanuele Persichetti ; Lucilla Parnetti ; Michele Sbaragli ; Carmelo Tassi ; Aldo Orlacchio ; Paolo Calabresi ; Tommaso Beccari ; Aroldo RossiSource :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
English descriptors
Abstract
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21399
Links to Exploration step
ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name><affiliation><mods:affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name><affiliation><mods:affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21399</idno><idno type="url">https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003127</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><author><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name><affiliation><mods:affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name><affiliation><mods:affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation><mods:affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name><affiliation><mods:affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-30">2007-07-30</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1481">1481</biblScope><biblScope unit="page" to="1484">1484</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AE0D8221BED66F75366B199F2FD3D66647D24058</idno><idno type="DOI">10.1002/mds.21399</idno><idno type="ArticleID">MDS21399</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>α‐mannosidase</term><term>β‐glucocerebrosidase</term><term>β‐hexosaminidase</term><term>β‐mannosidase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Chiara Balducci PhD</name><affiliations><json:string>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Laura Pierguidi MD</name><affiliations><json:string>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</json:string><json:string>Fondazione Santa Lucia, IRCCS, Roma, Italy</json:string></affiliations></json:item><json:item><name>Emanuele Persichetti PhD</name><affiliations><json:string>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Lucilla Parnetti MD</name><affiliations><json:string>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Michele Sbaragli PhD</name><affiliations><json:string>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Carmelo Tassi PhD</name><affiliations><json:string>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Aldo Orlacchio PhD</name><affiliations><json:string>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Paolo Calabresi MD</name><affiliations><json:string>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</json:string><json:string>Fondazione Santa Lucia, IRCCS, Roma, Italy</json:string></affiliations></json:item><json:item><name>Tommaso Beccari PhD</name><affiliations><json:string>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item><json:item><name>Aroldo Rossi MD</name><affiliations><json:string>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>β‐glucocerebrosidase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α‐mannosidase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>β‐mannosidase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>β‐hexosaminidase</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>3.771</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>821</abstractCharCount><pdfWordCount>2547</pdfWordCount><pdfCharCount>16864</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>102</abstractWordCount></qualityIndicators><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>22</volume><pages><total>3</total><last>1484</last><first>1481</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21399</json:string></doi><id>AE0D8221BED66F75366B199F2FD3D66647D24058</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><author><persName><forename type="first">Chiara</forename><surname>Balducci</surname><roleName type="degree">PhD</roleName></persName><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Laura</forename><surname>Pierguidi</surname><roleName type="degree">MD</roleName></persName><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation></author><author><persName><forename type="first">Emanuele</forename><surname>Persichetti</surname><roleName type="degree">PhD</roleName></persName><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Lucilla</forename><surname>Parnetti</surname><roleName type="degree">MD</roleName></persName><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Michele</forename><surname>Sbaragli</surname><roleName type="degree">PhD</roleName></persName><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Carmelo</forename><surname>Tassi</surname><roleName type="degree">PhD</roleName></persName><affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Aldo</forename><surname>Orlacchio</surname><roleName type="degree">PhD</roleName></persName><affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Calabresi</surname><roleName type="degree">MD</roleName></persName><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation></author><author><persName><forename type="first">Tommaso</forename><surname>Beccari</surname><roleName type="degree">PhD</roleName></persName><note type="correspondence"><p>Correspondence: Dipartimento di Medicina Interna Università degli Studi di Perugia, via del Giochetto, 06126 Perugia, Italy</p></note><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation></author><author><persName><forename type="first">Aroldo</forename><surname>Rossi</surname><roleName type="degree">MD</roleName></persName><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-30"></date><biblScope unit="vol">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1481">1481</biblScope><biblScope unit="page" to="1484">1484</biblScope></imprint></monogr><idno type="istex">AE0D8221BED66F75366B199F2FD3D66647D24058</idno><idno type="DOI">10.1002/mds.21399</idno><idno type="ArticleID">MDS21399</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>β‐glucocerebrosidase</term></item><item><term>α‐mannosidase</term></item><item><term>β‐mannosidase</term></item><item><term>β‐hexosaminidase</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-12-05">Received</change><change when="2006-12-15">Registration</change><change when="2007-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AE0D8221BED66F75366B199F2FD3D66647D24058/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley" registered="yes">10.1002/mds.v22:10</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2007-07-30">30 July 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="170" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21399</doi><idGroup><id type="unit" value="MDS21399"></id></idGroup><countGroup><count type="pageTotal" number="3"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2006-12-05"></event><event type="manuscriptAccepted" date="2006-12-15"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-06-01"></event><event type="firstOnline" date="2007-06-01"></event><event type="publishedOnlineFinalForm" date="2007-07-23"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1481</numbering><numbering type="pageLast">1484</numbering></numberingGroup><correspondenceTo>Dipartimento di Medicina Interna Università degli Studi di Perugia, via del Giochetto, 06126 Perugia, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21399.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="15"></count><count type="wordTotal" number="2058"></count></countGroup><titleGroup><title type="main" xml:lang="en">Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><title type="short" xml:lang="en">Lysosomal Hydrolases in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Chiara</givenNames><familyName>Balducci</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Laura</givenNames><familyName>Pierguidi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Emanuele</givenNames><familyName>Persichetti</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Lucilla</givenNames><familyName>Parnetti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michele</givenNames><familyName>Sbaragli</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Carmelo</givenNames><familyName>Tassi</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Aldo</givenNames><familyName>Orlacchio</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Paolo</givenNames><familyName>Calabresi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Tommaso</givenNames><familyName>Beccari</familyName><degrees>PhD</degrees></personName><contactDetails><email>tbeccari@unipg.it</email></contactDetails></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Aroldo</givenNames><familyName>Rossi</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">β‐glucocerebrosidase</keyword><keyword xml:id="kwd3">α‐mannosidase</keyword><keyword xml:id="kwd4">β‐mannosidase</keyword><keyword xml:id="kwd5">β‐hexosaminidase</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Lysosomal Hydrolases in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Chiara</namePart><namePart type="family">Balducci</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Pierguidi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emanuele</namePart><namePart type="family">Persichetti</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucilla</namePart><namePart type="family">Parnetti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michele</namePart><namePart type="family">Sbaragli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmelo</namePart><namePart type="family">Tassi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Orlacchio</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Calabresi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><affiliation>Fondazione Santa Lucia, IRCCS, Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tommaso</namePart><namePart type="family">Beccari</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy</affiliation><description>Correspondence: Dipartimento di Medicina Interna Università degli Studi di Perugia, via del Giochetto, 06126 Perugia, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aroldo</namePart><namePart type="family">Rossi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-07-30</dateIssued><dateCaptured encoding="w3cdtf">2006-12-05</dateCaptured><dateValid encoding="w3cdtf">2006-12-15</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">15</extent><extent unit="words">2058</extent></physicalDescription><abstract lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>β‐glucocerebrosidase</topic><topic>α‐mannosidase</topic><topic>β‐mannosidase</topic><topic>β‐hexosaminidase</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1481</start><end>1484</end><total>3</total></extent></part></relatedItem><identifier type="istex">AE0D8221BED66F75366B199F2FD3D66647D24058</identifier><identifier type="DOI">10.1002/mds.21399</identifier><identifier type="ArticleID">MDS21399</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003127 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003127 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:AE0D8221BED66F75366B199F2FD3D66647D24058
|texte= Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |