MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 001603

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Identifieur interne : 001603 ( PascalFrancis/Checkpoint ); précédent : 001602; suivant : 001604

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Auteurs : Chiara Balducci [Italie] ; Laura Pierguidi [Italie] ; Emanuele Persichetti [Italie] ; Lucilla Parnetti [Italie] ; Michele Sbaragli [Italie] ; Carmelo Tassi [Italie] ; Aldo Orlacchio [Italie] ; Paolo Calabresi [Italie] ; Tommaso Beccari [Italie] ; Aroldo Rossi [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0393271

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Hydrolases, Liquide céphalorachidien, Homme, α-Mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Cerebrospinal fluid, Human, Hydrolases, Nervous system diseases, Parkinson disease, α-Mannosidase, β-Mannosidase, β-N-Acetylhexosaminidase.

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

Affiliations:

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Pascal:07-0393271

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</div>
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<fC01 i1="01" l="ENG"><s0>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β-glucocerebrosidase and the activities of other lysosomal enzymes, α-mannosidase, β-mannosidase, β-hexosaminidase, and β-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α-mannosidase, β-mannosidase, β-glucocerebrosidase, and β-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Liquide céphalorachidien</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Cerebrospinal fluid</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Líquido cefalorraquídeo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>α-Mannosidase</s0>
<s2>FE</s2>
<s5>12</s5>
<s6>«α»-Mannosidase</s6>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>α-Mannosidase</s0>
<s2>FE</s2>
<s5>12</s5>
<s6>«α»-Mannosidase</s6>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>α-Mannosidase</s0>
<s2>FE</s2>
<s5>12</s5>
<s6>«α»-Mannosidase</s6>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>β-Mannosidase</s0>
<s2>FE</s2>
<s5>13</s5>
<s6>«β»-Mannosidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>β-N-Acetylhexosaminidase</s0>
<s2>FE</s2>
<s5>14</s5>
<s6>«β-N»-Acetylhexosaminidase</s6>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>O-Glycosidases</s0>
<s2>FE</s2>
<s6>«O»-Glycosidases</s6>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Glycosidases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>253</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
</region>
<settlement><li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Balducci, Chiara" sort="Balducci, Chiara" uniqKey="Balducci C" first="Chiara" last="Balducci">Chiara Balducci</name>
</noRegion>
<name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name>
<name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<name sortKey="Calabresi, Paolo" sort="Calabresi, Paolo" uniqKey="Calabresi P" first="Paolo" last="Calabresi">Paolo Calabresi</name>
<name sortKey="Orlacchio, Aldo" sort="Orlacchio, Aldo" uniqKey="Orlacchio A" first="Aldo" last="Orlacchio">Aldo Orlacchio</name>
<name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<name sortKey="Persichetti, Emanuele" sort="Persichetti, Emanuele" uniqKey="Persichetti E" first="Emanuele" last="Persichetti">Emanuele Persichetti</name>
<name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
<name sortKey="Pierguidi, Laura" sort="Pierguidi, Laura" uniqKey="Pierguidi L" first="Laura" last="Pierguidi">Laura Pierguidi</name>
<name sortKey="Rossi, Aroldo" sort="Rossi, Aroldo" uniqKey="Rossi A" first="Aroldo" last="Rossi">Aroldo Rossi</name>
<name sortKey="Sbaragli, Michele" sort="Sbaragli, Michele" uniqKey="Sbaragli M" first="Michele" last="Sbaragli">Michele Sbaragli</name>
<name sortKey="Tassi, Carmelo" sort="Tassi, Carmelo" uniqKey="Tassi C" first="Carmelo" last="Tassi">Carmelo Tassi</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

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