Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Identifieur interne : 001451 ( Main/Exploration ); précédent : 001450; suivant : 001452Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Auteurs : T. M. Tsfasman [Russie] ; S. G. Markushin [Russie] ; I. I. Akopova [Russie] ; Y. Z. Ghendon [Russie]Source :
- Journal of general virology [ 0022-1317 ] ; 2007.
Descripteurs français
- KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
- MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- Pascal (Inist)
English descriptors
- KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza A virus, Influenza, Human (immunology), Influenza, Human (prevention & control), Mechanism of action, Microbiology, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Reversion, Strain, Temperature, Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.
Abstract
A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
Affiliations:
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Le document en format XML
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<term>Cold Temperature</term>
<term>Genetic Complementation Test</term>
<term>Genotype</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (physiology)</term>
<term>Influenza A virus</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Mechanism of action</term>
<term>Microbiology</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Polymorphism, Single-Stranded Conformational</term>
<term>Recombination, Genetic</term>
<term>Reversion</term>
<term>Strain</term>
<term>Temperature</term>
<term>Viral Nonstructural Proteins (genetics)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Acclimatation</term>
<term>Basse température</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation</term>
<term>Phénotype</term>
<term>Polymorphisme de conformation simple brin</term>
<term>Protéines virales non structurales (génétique)</term>
<term>Recombinaison génétique</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (physiologie)</term>
<term>Test de complémentation</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Nonstructural Proteins</term>
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</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales non structurales</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
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<keywords scheme="MESH" xml:lang="en"><term>Acclimatization</term>
<term>Cold Temperature</term>
<term>Genetic Complementation Test</term>
<term>Genotype</term>
<term>Humans</term>
<term>Mutation</term>
<term>Phenotype</term>
<term>Polymorphism, Single-Stranded Conformational</term>
<term>Recombination, Genetic</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Acclimatation</term>
<term>Basse température</term>
<term>Grippe humaine</term>
<term>Génotype</term>
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<term>Mutation</term>
<term>Phénotype</term>
<term>Polymorphisme de conformation simple brin</term>
<term>Recombinaison génétique</term>
<term>Test de complémentation</term>
<term>Virus grippal A</term>
<term>Mécanisme action</term>
<term>Réversion</term>
<term>Température</term>
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<front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
</front>
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