Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Identifieur interne : 000244 ( Ncbi/Checkpoint ); précédent : 000243; suivant : 000245Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Auteurs : T M Tsfasman [Russie] ; S G Markushin ; I I Akopova ; Y Z GhendonSource :
- The Journal of general virology [ 0022-1317 ] ; 2007.
Descripteurs français
- KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
- MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- Acclimatation, Basse température, Grippe humaine, Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Recombinaison génétique, Test de complémentation.
English descriptors
- KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.
Abstract
A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
DOI: 10.1099/vir.0.83014-0
PubMed: 17872525
Affiliations:
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pubmed:17872525Le document en format XML
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Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><noCountry><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y Z" last="Ghendon">Y Z Ghendon</name><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name></noCountry><country name="Russie"><region name="District fédéral central"><name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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