H2N2V1, Main, Curation, bibRecord, 001451

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Identifieur interne : 001451 ( Main/Curation ); précédent : 001450; suivant : 001452

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Auteurs : T. M. Tsfasman [Russie] ; S. G. Markushin [Russie] ; I. I. Akopova [Russie] ; Y. Z. Ghendon [Russie]

Source :

Journal of general virology [ 0022-1317 ] ; 2007.

RBID : Pascal:07-0486627

Descripteurs français

KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
Pascal (Inist)
- Acclimatation, Basse température, Grippe humaine, Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Recombinaison génétique, Test de complémentation, Virus grippal A, Mécanisme action, Réversion, Température, Phénotype, Souche, Microbiologie.

English descriptors

KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza A virus, Influenza, Human (immunology), Influenza, Human (prevention & control), Mechanism of action, Microbiology, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Reversion, Strain, Temperature, Viral Nonstructural Proteins (genetics).
MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.

Abstract

A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.

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Le document en format XML

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<term>Protéines virales non structurales (génétique)</term>
<term>Recombinaison génétique</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (physiologie)</term>
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<front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
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<front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
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<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
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<front><div type="abstract" xml:lang="en">A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
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Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

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