Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Identifieur interne : 000038 ( PascalFrancis/Curation ); précédent : 000037; suivant : 000039Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Auteurs : T. M. Tsfasman [Russie] ; S. G. Markushin [Russie] ; I. I. Akopova [Russie] ; Y. Z. Ghendon [Russie]Source :
- Journal of general virology [ 0022-1317 ] ; 2007.
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Abstract
A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
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