Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Identifieur interne : 000273 ( PubMed/Curation ); précédent : 000272; suivant : 000274Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Auteurs : T M Tsfasman [Russie] ; S G Markushin ; I I Akopova ; Y Z GhendonSource :
- The Journal of general virology [ 0022-1317 ] ; 2007.
Descripteurs français
- KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
- MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- Acclimatation, Basse température, Grippe humaine, Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Recombinaison génétique, Test de complémentation.
English descriptors
- KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.
Abstract
A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
DOI: 10.1099/vir.0.83014-0
PubMed: 17872525
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pubmed:17872525Le document en format XML
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brin</term><term>Protéines virales non structurales (génétique)</term><term>Recombinaison génétique</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (physiologie)</term><term>Test de complémentation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales non structurales</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acclimatization</term><term>Cold Temperature</term><term>Genetic Complementation Test</term><term>Genotype</term><term>Humans</term><term>Mutation</term><term>Phenotype</term><term>Polymorphism, Single-Stranded Conformational</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acclimatation</term><term>Basse température</term><term>Grippe humaine</term><term>Génotype</term><term>Humains</term><term>Mutation</term><term>Phénotype</term><term>Polymorphisme de conformation simple brin</term><term>Recombinaison génétique</term><term>Test de complémentation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17872525</PMID><DateCompleted><Year>2007</Year><Month>10</Month><Day>26</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1317</ISSN><JournalIssue CitedMedium="Print"><Volume>88</Volume><Issue>Pt 10</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of general virology</Title><ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation></Journal><ArticleTitle>Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.</ArticleTitle><Pagination><MedlinePgn>2724-9</MedlinePgn></Pagination><Abstract><AbstractText>A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. 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