Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Identifieur interne : 001470 ( Main/Merge ); précédent : 001469; suivant : 001471Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Auteurs : T. M. Tsfasman [Russie] ; S. G. Markushin [Russie] ; I. I. Akopova [Russie] ; Y. Z. Ghendon [Russie]Source :
- Journal of general virology [ 0022-1317 ] ; 2007.
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- Pascal (Inist)
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Abstract
A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
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M." last="Tsfasman">T. M. Tsfasman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S. G." last="Markushin">S. G. Markushin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I. I." last="Akopova">I. I. Akopova</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y. Z." last="Ghendon">Y. Z. Ghendon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Influenza A virus</term><term>Mechanism of action</term><term>Microbiology</term><term>Phenotype</term><term>Reversion</term><term>Strain</term><term>Temperature</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Mécanisme action</term><term>Réversion</term><term>Température</term><term>Phénotype</term><term>Souche</term><term>Microbiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T. M." last="Tsfasman">T. M. Tsfasman</name></region><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I. I." last="Akopova">I. I. Akopova</name><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y. Z." last="Ghendon">Y. Z. Ghendon</name><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S. G." last="Markushin">S. G. Markushin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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