Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Identifieur interne : 001383 ( Main/Merge ); précédent : 001382; suivant : 001384Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains.
Auteurs : T M Tsfasman [Russie] ; S G Markushin ; I I Akopova ; Y Z GhendonSource :
- The Journal of general virology [ 0022-1317 ] ; 2007.
Descripteurs français
- KwdFr :
- Acclimatation, Basse température, Grippe humaine (), Grippe humaine (immunologie), Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Protéines virales non structurales (génétique), Recombinaison génétique, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (physiologie), Test de complémentation.
- MESH :
- génétique : Protéines virales non structurales, Sous-type H2N2 du virus de la grippe A.
- immunologie : Grippe humaine.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- Acclimatation, Basse température, Grippe humaine, Génotype, Humains, Mutation, Phénotype, Polymorphisme de conformation simple brin, Recombinaison génétique, Test de complémentation.
English descriptors
- KwdEn :
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (physiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic, Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza, Human.
- physiology : Influenza A Virus, H2N2 Subtype.
- prevention & control : Influenza, Human.
- Acclimatization, Cold Temperature, Genetic Complementation Test, Genotype, Humans, Mutation, Phenotype, Polymorphism, Single-Stranded Conformational, Recombination, Genetic.
Abstract
A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
DOI: 10.1099/vir.0.83014-0
PubMed: 17872525
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pubmed:17872525Le document en format XML
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<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
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<term>Influenza, Human (prevention & control)</term>
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<term>Mutation</term>
<term>Phenotype</term>
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<front><div type="abstract" xml:lang="en">A ts+ ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div>
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