Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Identifieur interne : 000036 ( PascalFrancis/Corpus ); précédent : 000035; suivant : 000037Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains
Auteurs : T. M. Tsfasman ; S. G. Markushin ; I. I. Akopova ; Y. Z. GhendonSource :
- Journal of general virology [ 0022-1317 ] ; 2007.
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Abstract
A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.
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| NO : | PASCAL 07-0486627 INIST |
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| ET : | Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains |
| AU : | TSFASMAN (T. M.); MARKUSHIN (S. G.); AKOPOVA (I. I.); GHENDON (Y. Z.) |
| AF : | Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15/115088 Moscow/Russie (1 aut., 2 aut., 3 aut., 4 aut.) |
| DT : | Publication en série; Courte communication, note brève; Niveau analytique |
| SO : | Journal of general virology; ISSN 0022-1317; Coden JGVIAY; Royaume-Uni; Da. 2007; Vol. 88; No. p. 10; Pp. 2724-2729; Bibl. 3/4 p. |
| LA : | Anglais |
| EA : | A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes. |
| CC : | 002A05C10 |
| FD : | Virus grippal A; Mécanisme action; Réversion; Température; Phénotype; Souche; Microbiologie |
| FG : | Influenzavirus A; Orthomyxoviridae; Virus |
| ED : | Influenza A virus; Mechanism of action; Reversion; Temperature; Phenotype; Strain; Microbiology |
| EG : | Influenzavirus A; Orthomyxoviridae; Virus |
| SD : | Influenza A virus; Mecanismo acción; Reversión; Temperatura; Fenotipo; Cepa; Microbiología |
| LO : | INIST-13533.354000162554330140 |
| ID : | 07-0486627 |
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Pascal:07-0486627Le document en format XML
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Tsfasman</name><affiliation><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S. G." last="Markushin">S. G. Markushin</name><affiliation><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I. I." last="Akopova">I. I. Akopova</name><affiliation><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y. Z." last="Ghendon">Y. Z. Ghendon</name><affiliation><inist:fA14 i1="01"><s1>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15</s1><s2>115088 Moscow</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Influenza A virus</term><term>Mechanism of action</term><term>Microbiology</term><term>Phenotype</term><term>Reversion</term><term>Strain</term><term>Temperature</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Mécanisme action</term><term>Réversion</term><term>Température</term><term>Phénotype</term><term>Souche</term><term>Microbiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1317</s0></fA01><fA02 i1="01"><s0>JGVIAY</s0></fA02><fA03 i2="1"><s0>J. gen. virol.</s0></fA03><fA05><s2>88</s2></fA05><fA06><s3>p. 10</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Molecular mechanisms of reversion to the ts + (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains</s1></fA08><fA11 i1="01" i2="1"><s1>TSFASMAN (T. M.)</s1></fA11><fA11 i1="02" i2="1"><s1>MARKUSHIN (S. G.)</s1></fA11><fA11 i1="03" i2="1"><s1>AKOPOVA (I. I.)</s1></fA11><fA11 i1="04" i2="1"><s1>GHENDON (Y. 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All rights reserved.</s1></fA44><fA45><s0>3/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0486627</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of general virology</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. 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M.); MARKUSHIN (S. G.); AKOPOVA (I. I.); GHENDON (Y. Z.)</AU><AF>Mechnikov Research Institute for Vaccines and Sera, 115088, 1st Dubrovskaja Str. 15/115088 Moscow/Russie (1 aut., 2 aut., 3 aut., 4 aut.)</AF><DT>Publication en série; Courte communication, note brève; Niveau analytique</DT><SO>Journal of general virology; ISSN 0022-1317; Coden JGVIAY; Royaume-Uni; Da. 2007; Vol. 88; No. p. 10; Pp. 2724-2729; Bibl. 3/4 p.</SO><LA>Anglais</LA><EA>A ts + ca- (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/ 57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.</EA><CC>002A05C10</CC><FD>Virus grippal A; Mécanisme action; Réversion; Température; Phénotype; Souche; Microbiologie</FD><FG>Influenzavirus A; Orthomyxoviridae; Virus</FG><ED>Influenza A virus; Mechanism of action; Reversion; Temperature; Phenotype; Strain; Microbiology</ED><EG>Influenzavirus A; Orthomyxoviridae; Virus</EG><SD>Influenza A virus; Mecanismo acción; Reversión; Temperatura; Fenotipo; Cepa; Microbiología</SD><LO>INIST-13533.354000162554330140</LO><ID>07-0486627</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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