Memory activation reveals abnormal EEG in preclinical Huntington's disease
Identifieur interne : 002D49 ( Main/Exploration ); précédent : 002D48; suivant : 002D50Memory activation reveals abnormal EEG in preclinical Huntington's disease
Auteurs : Karin Van Der Hiele [Pays-Bas] ; Caroline K. Jurgens [Pays-Bas] ; Alla A. Vein [Pays-Bas] ; Robert H. A. M. Reijntjes [Pays-Bas] ; Marie-Noëlle W. Witjes-Ané [Pays-Bas] ; Raymund A. C. Roos [Pays-Bas] ; Gert Van Dijk [Pays-Bas] ; Huub A. M. Middelkoop [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Alpha Rhythm, Asymptomatic, Cerebral Cortex (physiopathology), EEG, Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington Disease (physiopathology), Huntington disease, Huntington's disease, Male, Memory, Memory, Short-Term (physiology), Middle Aged, Nervous system diseases, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats, memory activation, neuropsychology, preclinical.
- MESH :
- diagnosis : Huntington Disease.
- genetics : Huntington Disease.
- physiology : Memory, Short-Term.
- physiopathology : Cerebral Cortex, Huntington Disease.
- Adult, Alpha Rhythm, Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats.
Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4–8 Hz) and alpha (8–13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21390
Affiliations:
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<front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4–8 Hz) and alpha (8–13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt. © 2007 Movement Disorder Society</div>
</front>
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<name sortKey="Witjes Ne, Marie Oelle W" sort="Witjes Ne, Marie Oelle W" uniqKey="Witjes Ne M" first="Marie-Noëlle W." last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name>
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