MovDisordV3, PascalFrancis, Corpus, bibRecord, 001721

Memory activation reveals abnormal EEG in preclinical Huntington's disease

Identifieur interne : 001721 ( PascalFrancis/Corpus ); précédent : 001720; suivant : 001722

Memory activation reveals abnormal EEG in preclinical Huntington's disease

Auteurs : Karin Van Der Hiele ; Caroline K. Jurgens ; Alla A. Vein ; Robert H. A. M. Reijntjes ; Marie-Noëlle W. Witjes-Ane ; Raymund A. C. Roos ; Gert Van Dijk ; Huub A. M. Middelkoop

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0263036

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Chorée Huntington, Mémoire, Electroencéphalographie, Asymptomatique.

English descriptors

KwdEn :
- Asymptomatic, Electroencephalography, Huntington disease, Memory, Nervous system diseases.

Abstract

The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Memory activation reveals abnormal EEG in preclinical Huntington's disease`
A11	`01`	`1`		`@1 VAN DER HIELE (Karin)`
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A11	`03`	`1`		`@1 VEIN (Alla A.)`
A11	`04`	`1`		`@1 REIJNTJES (Robert H. A. M.)`
A11	`05`	`1`		`@1 WITJES-ANE (Marie-Noëlle W.)`
A11	`06`	`1`		`@1 ROOS (Raymund A. C.)`
A11	`07`	`1`		`@1 VAN DIJK (Gert)`
A11	`08`	`1`		`@1 MIDDELKOOP (Huub A. M.)`
A14	`01`			`@1 Section of Neuropsychology, Department of Neurology, Leiden University Medical Center @2 Leiden @3 NLD @Z 1 aut. @Z 2 aut. @Z 5 aut. @Z 8 aut.`
A14	`02`			`@1 Neuropsychology Unit of the Department of Psychology, Leiden University @2 Leiden @3 NLD @Z 1 aut. @Z 8 aut.`
A14	`03`			`@1 Section of Clinical Neurophysiology, Department of Neurology, Leiden University @2 Leiden @3 NLD @Z 3 aut. @Z 4 aut. @Z 7 aut.`
A14	`04`			`@1 Department of Neurology, Leiden University @2 Leiden @3 NLD @Z 6 aut.`
A20				`@1 690-695`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000149439720140`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Chorée Huntington @5 02`
C03	`02`	`X`	`ENG`	`@0 Huntington disease @5 02`
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C03	`03`	`X`	`SPA`	`@0 Memoria @5 09`
C03	`04`	`X`	`FRE`	`@0 Electroencéphalographie @5 10`
C03	`04`	`X`	`ENG`	`@0 Electroencephalography @5 10`
C03	`04`	`X`	`SPA`	`@0 Electroencefalografía @5 10`
C03	`05`	`X`	`FRE`	`@0 Asymptomatique @5 11`
C03	`05`	`X`	`ENG`	`@0 Asymptomatic @5 11`
C03	`05`	`X`	`SPA`	`@0 Asintomático @5 11`
C07	`01`	`X`	`FRE`	`@0 Electrophysiologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Electrophysiology @5 37`
C07	`01`	`X`	`SPA`	`@0 Electrofisiología @5 37`
C07	`02`	`X`	`FRE`	`@0 Encéphale pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
C07	`04`	`X`	`ENG`	`@0 Degenerative disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie héréditaire @5 41`
C07	`05`	`X`	`ENG`	`@0 Genetic disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 41`
C07	`06`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 42`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 42`
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Format Inist (serveur)

NO :	PASCAL 07-0263036 INIST
ET :	Memory activation reveals abnormal EEG in preclinical Huntington's disease
AU :	VAN DER HIELE (Karin); JURGENS (Caroline K.); VEIN (Alla A.); REIJNTJES (Robert H. A. M.); WITJES-ANE (Marie-Noëlle W.); ROOS (Raymund A. C.); VAN DIJK (Gert); MIDDELKOOP (Huub A. M.)
AF :	Section of Neuropsychology, Department of Neurology, Leiden University Medical Center/Leiden/Pays-Bas (1 aut., 2 aut., 5 aut., 8 aut.); Neuropsychology Unit of the Department of Psychology, Leiden University/Leiden/Pays-Bas (1 aut., 8 aut.); Section of Clinical Neurophysiology, Department of Neurology, Leiden University/Leiden/Pays-Bas (3 aut., 4 aut., 7 aut.); Department of Neurology, Leiden University/Leiden/Pays-Bas (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 5; Pp. 690-695; Bibl. 29 ref.
LA :	Anglais
EA :	The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
CC :	002B17; 002B17G; 002B24D02
FD :	Système nerveux pathologie; Chorée Huntington; Mémoire; Electroencéphalographie; Asymptomatique
FG :	Electrophysiologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie
ED :	Nervous system diseases; Huntington disease; Memory; Electroencephalography; Asymptomatic
EG :	Electrophysiology; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease
SD :	Sistema nervioso patología; Corea Huntington; Memoria; Electroencefalografía; Asintomático
LO :	INIST-20953.354000149439720140
ID :	07-0263036

Links to Exploration step

Pascal:07-0263036

Le document en format XML

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<author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymptomatic</term>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</div>
</front>
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<fA11 i1="01" i2="1"><s1>VAN DER HIELE (Karin)</s1>
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<fA11 i1="08" i2="1"><s1>MIDDELKOOP (Huub A. M.)</s1>
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<fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurology, Leiden University</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>690-695</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000149439720140</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0263036</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B24D02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Chorée Huntington</s0>
<s5>02</s5>
</fC03>
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<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Corea Huntington</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Mémoire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Memory</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Memoria</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Electroencéphalographie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Electroencephalography</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Electroencefalografía</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Asymptomatique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Asymptomatic</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Asintomático</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Electrophysiologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Electrophysiology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>176</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 07-0263036 INIST</NO>
<ET>Memory activation reveals abnormal EEG in preclinical Huntington's disease</ET>
<AU>VAN DER HIELE (Karin); JURGENS (Caroline K.); VEIN (Alla A.); REIJNTJES (Robert H. A. M.); WITJES-ANE (Marie-Noëlle W.); ROOS (Raymund A. C.); VAN DIJK (Gert); MIDDELKOOP (Huub A. M.)</AU>
<AF>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center/Leiden/Pays-Bas (1 aut., 2 aut., 5 aut., 8 aut.); Neuropsychology Unit of the Department of Psychology, Leiden University/Leiden/Pays-Bas (1 aut., 8 aut.); Section of Clinical Neurophysiology, Department of Neurology, Leiden University/Leiden/Pays-Bas (3 aut., 4 aut., 7 aut.); Department of Neurology, Leiden University/Leiden/Pays-Bas (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 5; Pp. 690-695; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</EA>
<CC>002B17; 002B17G; 002B24D02</CC>
<FD>Système nerveux pathologie; Chorée Huntington; Mémoire; Electroencéphalographie; Asymptomatique</FD>
<FG>Electrophysiologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Huntington disease; Memory; Electroencephalography; Asymptomatic</ED>
<EG>Electrophysiology; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Corea Huntington; Memoria; Electroencefalografía; Asintomático</SD>
<LO>INIST-20953.354000149439720140</LO>
<ID>07-0263036</ID>
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Movement Disorders (revue)

Memory activation reveals abnormal EEG in preclinical Huntington's disease

Memory activation reveals abnormal EEG in preclinical Huntington's disease

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