Memory activation reveals abnormal EEG in preclinical Huntington's disease
Identifieur interne : 001593 ( PascalFrancis/Checkpoint ); précédent : 001592; suivant : 001594Memory activation reveals abnormal EEG in preclinical Huntington's disease
Auteurs : Karin Van Der Hiele [Pays-Bas] ; Caroline K. Jurgens [Pays-Bas] ; Alla A. Vein [Pays-Bas] ; Robert H. A. M. Reijntjes [Pays-Bas] ; Marie-Noëlle W. Witjes-Ane [Pays-Bas] ; Raymund A. C. Roos [Pays-Bas] ; Gert Van Dijk [Pays-Bas] ; Huub A. M. Middelkoop [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
English descriptors
Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
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Jurgens</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W." last="Witjes-Ane">Marie-Noëlle W. Witjes-Ane</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymptomatic</term><term>Electroencephalography</term><term>Huntington disease</term><term>Memory</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Chorée Huntington</term><term>Mémoire</term><term>Electroencéphalographie</term><term>Asymptomatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>22</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Memory activation reveals abnormal EEG in preclinical Huntington's disease</s1></fA08><fA11 i1="01" i2="1"><s1>VAN DER HIELE (Karin)</s1></fA11><fA11 i1="02" i2="1"><s1>JURGENS (Caroline K.)</s1></fA11><fA11 i1="03" i2="1"><s1>VEIN (Alla A.)</s1></fA11><fA11 i1="04" i2="1"><s1>REIJNTJES (Robert H. A. M.)</s1></fA11><fA11 i1="05" i2="1"><s1>WITJES-ANE (Marie-Noëlle W.)</s1></fA11><fA11 i1="06" i2="1"><s1>ROOS (Raymund A. C.)</s1></fA11><fA11 i1="07" i2="1"><s1>VAN DIJK (Gert)</s1></fA11><fA11 i1="08" i2="1"><s1>MIDDELKOOP (Huub A. M.)</s1></fA11><fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>6 aut.</sZ></fA14><fA20><s1>690-695</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000149439720140</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>29 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0263036</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B24D02</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Chorée Huntington</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Huntington disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Corea Huntington</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Mémoire</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Memory</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Memoria</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Electroencéphalographie</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Electroencephalography</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Electroencefalografía</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Asymptomatique</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Asymptomatic</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Asintomático</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Electrophysiologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Electrophysiology</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Electrofisiología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Genetic disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>42</s5></fC07><fN21><s1>176</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name></region><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W." last="Witjes-Ane">Marie-Noëlle W. Witjes-Ane</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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