Memory activation reveals abnormal EEG in preclinical Huntington's disease
Identifieur interne : 004183 ( Main/Merge ); précédent : 004182; suivant : 004184Memory activation reveals abnormal EEG in preclinical Huntington's disease
Auteurs : Karin Van Der Hiele [Pays-Bas] ; Caroline K. Jurgens [Pays-Bas] ; Alla A. Vein [Pays-Bas] ; Robert H. A. M. Reijntjes [Pays-Bas] ; Marie-Noëlle W. Witjes-Ane [Pays-Bas] ; Raymund A. C. Roos [Pays-Bas] ; Gert Van Dijk [Pays-Bas] ; Huub A. M. Middelkoop [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
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M." last="Middelkoop">Huub A. M. Middelkoop</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0263036</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0263036 INIST</idno><idno type="RBID">Pascal:07-0263036</idno><idno type="wicri:Area/PascalFrancis/Corpus">001721</idno><idno type="wicri:Area/PascalFrancis/Curation">001600</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001593</idno><idno type="wicri:doubleKey">0885-3185:2007:Van Der Hiele K:memory:activation:reveals</idno><idno type="wicri:Area/Main/Merge">004183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Memory activation reveals abnormal EEG in preclinical Huntington's disease</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W." last="Witjes-Ane">Marie-Noëlle W. Witjes-Ane</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>6 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Section of Clinical Neurophysiology, Department of Neurology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Neuropsychology Unit of the Department of Psychology, Leiden University</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymptomatic</term><term>Electroencephalography</term><term>Huntington disease</term><term>Memory</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Chorée Huntington</term><term>Mémoire</term><term>Electroencéphalographie</term><term>Asymptomatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name></region><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W." last="Witjes-Ane">Marie-Noëlle W. Witjes-Ane</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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