Memory activation reveals abnormal EEG in preclinical Huntington's disease
Identifieur interne : 003C71 ( Main/Merge ); précédent : 003C70; suivant : 003C72Memory activation reveals abnormal EEG in preclinical Huntington's disease
Auteurs : Karin Van Der Hiele [Pays-Bas] ; Caroline K. Jurgens [Pays-Bas] ; Alla A. Vein [Pays-Bas] ; Robert H. A. M. Reijntjes [Pays-Bas] ; Marie-Noëlle W. Witjes-Ané [Pays-Bas] ; Raymund A. C. Roos [Pays-Bas] ; Gert Van Dijk [Pays-Bas] ; Huub A. M. Middelkoop [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
English descriptors
- KwdEn :
- Adult, Alpha Rhythm, Cerebral Cortex (physiopathology), EEG, Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington Disease (physiopathology), Huntington's disease, Male, Memory, Short-Term (physiology), Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats, memory activation, neuropsychology, preclinical.
- MESH :
- diagnosis : Huntington Disease.
- genetics : Huntington Disease.
- physiology : Memory, Short-Term.
- physiopathology : Cerebral Cortex, Huntington Disease.
- Adult, Alpha Rhythm, Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats.
Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4–8 Hz) and alpha (8–13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21390
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001A71
- to stream Istex, to step Curation: 001A71
- to stream Istex, to step Checkpoint: 001857
- to stream PubMed, to step Corpus: 002866
- to stream PubMed, to step Curation: 002866
- to stream PubMed, to step Checkpoint: 002721
- to stream Ncbi, to step Merge: 001A73
- to stream Ncbi, to step Curation: 001A73
- to stream Ncbi, to step Checkpoint: 001A73
Links to Exploration step
ISTEX:F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name></author><author><name sortKey="Witjes Ne, Marie Oelle W" sort="Witjes Ne, Marie Oelle W" uniqKey="Witjes Ne M" first="Marie-Noëlle W." last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21390</idno><idno type="url">https://api.istex.fr/document/F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A71</idno><idno type="wicri:Area/Istex/Curation">001A71</idno><idno type="wicri:Area/Istex/Checkpoint">001857</idno><idno type="wicri:doubleKey">0885-3185:2007:Van Der Hiele K:memory:activation:reveals</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17266047</idno><idno type="wicri:Area/PubMed/Corpus">002866</idno><idno type="wicri:Area/PubMed/Curation">002866</idno><idno type="wicri:Area/PubMed/Checkpoint">002721</idno><idno type="wicri:Area/Ncbi/Merge">001A73</idno><idno type="wicri:Area/Ncbi/Curation">001A73</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A73</idno><idno type="wicri:doubleKey">0885-3185:2007:Van Der Hiele K:memory:activation:reveals</idno><idno type="wicri:Area/Main/Merge">003C71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuropsychology Unit of the Department of Psychology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Witjes Ne, Marie Oelle W" sort="Witjes Ne, Marie Oelle W" uniqKey="Witjes Ne M" first="Marie-Noëlle W." last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuropsychology Unit of the Department of Psychology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="690">690</biblScope><biblScope unit="page" to="695">695</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043</idno><idno type="DOI">10.1002/mds.21390</idno><idno type="ArticleID">MDS21390</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Cerebral Cortex (physiopathology)</term><term>EEG</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (physiopathology)</term><term>Huntington's disease</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term><term>memory activation</term><term>neuropsychology</term><term>preclinical</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4–8 Hz) and alpha (8–13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt. © 2007 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.21390"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name></author><author><name sortKey="Witjes Ne, Marie Oelle W" sort="Witjes Ne, Marie Oelle W" uniqKey="Witjes Ne M" first="Marie-Noëlle W." last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21390</idno><idno type="url">https://api.istex.fr/document/F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A71</idno><idno type="wicri:Area/Istex/Curation">001A71</idno><idno type="wicri:Area/Istex/Checkpoint">001857</idno><idno type="wicri:doubleKey">0885-3185:2007:Van Der Hiele K:memory:activation:reveals</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuropsychology Unit of the Department of Psychology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K." last="Jurgens">Caroline K. Jurgens</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A." last="Vein">Alla A. Vein</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H. A. M." last="Reijntjes">Robert H. A. M. Reijntjes</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Witjes Ne, Marie Oelle W" sort="Witjes Ne, Marie Oelle W" uniqKey="Witjes Ne M" first="Marie-Noëlle W." last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A. C." last="Roos">Raymund A. C. Roos</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Clinical Neurophysiology, Department of Neurology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A. M." last="Middelkoop">Huub A. M. Middelkoop</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuropsychology Unit of the Department of Psychology, Leiden University, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="690">690</biblScope><biblScope unit="page" to="695">695</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043</idno><idno type="DOI">10.1002/mds.21390</idno><idno type="ArticleID">MDS21390</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EEG</term><term>Huntington's disease</term><term>memory activation</term><term>neuropsychology</term><term>preclinical</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4–8 Hz) and alpha (8–13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt. © 2007 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease.</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. k.van_der_hiele@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K" last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A" last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H A M" last="Reijntjes">Robert H A M. Reijntjes</name></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W" last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A M" last="Middelkoop">Huub A M. Middelkoop</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21390</idno><idno type="RBID">pubmed:17266047</idno><idno type="pmid">17266047</idno><idno type="wicri:Area/PubMed/Corpus">002866</idno><idno type="wicri:Area/PubMed/Curation">002866</idno><idno type="wicri:Area/PubMed/Checkpoint">002721</idno><idno type="wicri:Area/Ncbi/Merge">001A73</idno><idno type="wicri:Area/Ncbi/Curation">001A73</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A73</idno><idno type="wicri:doubleKey">0885-3185:2007:Van Der Hiele K:memory:activation:reveals</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease.</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="3"><nlm:affiliation>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. k.van_der_hiele@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K" last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A" last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H A M" last="Reijntjes">Robert H A M. Reijntjes</name></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W" last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A M" last="Middelkoop">Huub A M. Middelkoop</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Cerebral Cortex (physiopathology)</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (physiopathology)</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C71 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003C71 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:F352D7A22A1BBEAFDD45823AA2EE12A59BCD3043
|texte= Memory activation reveals abnormal EEG in preclinical Huntington's disease
}}
| This area was generated with Dilib version V0.6.23. |  |