Memory activation reveals abnormal EEG in preclinical Huntington's disease.
Identifieur interne : 002866 ( PubMed/Curation ); précédent : 002865; suivant : 002867Memory activation reveals abnormal EEG in preclinical Huntington's disease.
Auteurs : Karin Van Der Hiele [Pays-Bas] ; Caroline K. Jurgens ; Alla A. Vein ; Robert H A M. Reijntjes ; Marie-Noëlle W. Witjes-Ané ; Raymund A C. Roos ; Gert Van Dijk ; Huub A M. MiddelkoopSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Alpha Rhythm, Cerebral Cortex (physiopathology), Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington Disease (physiopathology), Male, Memory, Short-Term (physiology), Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats.
- MESH :
- diagnosis : Huntington Disease.
- genetics : Huntington Disease.
- physiology : Memory, Short-Term.
- physiopathology : Cerebral Cortex, Huntington Disease.
- Adult, Alpha Rhythm, Early Diagnosis, Electroencephalography, Female, Heterozygote Detection, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats.
Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
DOI: 10.1002/mds.21390
PubMed: 17266047
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease.</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. k.van_der_hiele@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K" last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A" last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H A M" last="Reijntjes">Robert H A M. Reijntjes</name></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W" last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A M" last="Middelkoop">Huub A M. Middelkoop</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21390</idno><idno type="RBID">pubmed:17266047</idno><idno type="pmid">17266047</idno><idno type="wicri:Area/PubMed/Corpus">002866</idno><idno type="wicri:Area/PubMed/Curation">002866</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Memory activation reveals abnormal EEG in preclinical Huntington's disease.</title><author><name sortKey="Van Der Hiele, Karin" sort="Van Der Hiele, Karin" uniqKey="Van Der Hiele K" first="Karin" last="Van Der Hiele">Karin Van Der Hiele</name><affiliation wicri:level="1"><nlm:affiliation>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. k.van_der_hiele@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline K" last="Jurgens">Caroline K. Jurgens</name></author><author><name sortKey="Vein, Alla A" sort="Vein, Alla A" uniqKey="Vein A" first="Alla A" last="Vein">Alla A. Vein</name></author><author><name sortKey="Reijntjes, Robert H A M" sort="Reijntjes, Robert H A M" uniqKey="Reijntjes R" first="Robert H A M" last="Reijntjes">Robert H A M. Reijntjes</name></author><author><name sortKey="Witjes Ane, Marie Noelle W" sort="Witjes Ane, Marie Noelle W" uniqKey="Witjes Ane M" first="Marie-Noëlle W" last="Witjes-Ané">Marie-Noëlle W. Witjes-Ané</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author><author><name sortKey="Van Dijk, Gert" sort="Van Dijk, Gert" uniqKey="Van Dijk G" first="Gert" last="Van Dijk">Gert Van Dijk</name></author><author><name sortKey="Middelkoop, Huub A M" sort="Middelkoop, Huub A M" uniqKey="Middelkoop H" first="Huub A M" last="Middelkoop">Huub A M. Middelkoop</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Cerebral Cortex (physiopathology)</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (physiopathology)</term><term>Male</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Alpha Rhythm</term><term>Early Diagnosis</term><term>Electroencephalography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Theta Rhythm</term><term>Trinucleotide Repeats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17266047</PMID><DateCreated><Year>2007</Year><Month>05</Month><Day>01</Day></DateCreated><DateCompleted><Year>2007</Year><Month>07</Month><Day>23</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>5</Issue><PubDate><Year>2007</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Memory activation reveals abnormal EEG in preclinical Huntington's disease.</ArticleTitle><Pagination><MedlinePgn>690-5</MedlinePgn></Pagination><Abstract><AbstractText>The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Hiele</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section of Neuropsychology, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. k.van_der_hiele@lumc.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jurgens</LastName><ForeName>Caroline K</ForeName><Initials>CK</Initials></Author><Author ValidYN="Y"><LastName>Vein</LastName><ForeName>Alla A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Reijntjes</LastName><ForeName>Robert H A M</ForeName><Initials>RH</Initials></Author><Author ValidYN="Y"><LastName>Witjes-Ané</LastName><ForeName>Marie-Noëlle W</ForeName><Initials>MN</Initials></Author><Author ValidYN="Y"><LastName>Roos</LastName><ForeName>Raymund A C</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>van Dijk</LastName><ForeName>Gert</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Middelkoop</LastName><ForeName>Huub A M</ForeName><Initials>HA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000513">Alpha Rhythm</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D042241">Early Diagnosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006580">Heterozygote Detection</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008570">Memory, Short-Term</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009460">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013826">Theta Rhythm</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018911">Trinucleotide Repeats</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>2</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>7</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>2</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21390</ArticleId><ArticleId IdType="pubmed">17266047</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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