Longitudinal tracking of gait and balance impairments in cerebellar disease
Identifieur interne : 001C04 ( Main/Curation ); précédent : 001C03; suivant : 001C05Longitudinal tracking of gait and balance impairments in cerebellar disease
Auteurs : Susanne M. Morton [États-Unis] ; Ya-Weng Tseng [États-Unis] ; Kathleen M. Zackowski [États-Unis] ; Jaclyn R. Daline [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Analysis of Variance, Ataxia, Cerebellar Diseases (physiopathology), Cerebellar disease, Cerebellum, Cerebellum (injuries), Cerebellum (physiopathology), Gait, Gait Ataxia (physiopathology), Humans, ICARS, Nervous system diseases, Neurologic Examination, Postural Balance, Sensitivity, Severity of Illness Index, Statistics, Nonparametric, Tracking, Walking, ataxia, cerebellum, clinical assessment, sensitivity, walking.
- MESH :
- injuries : Cerebellum.
- physiopathology : Cerebellar Diseases, Cerebellum, Gait Ataxia.
- Analysis of Variance, Gait, Humans, Neurologic Examination, Postural Balance, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173
DOI: 10.1002/mds.23169
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C10
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C10
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000883
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000091
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000091
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000332
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001809
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001809
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001791
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002B93
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002B93
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002B93
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002040
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000912
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :002407
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000977
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002564
Links to Exploration step
ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
</author>
<author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23169</idno>
<idno type="url">https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C10</idno>
<idno type="wicri:Area/Istex/Curation">000C10</idno>
<idno type="wicri:Area/Istex/Checkpoint">000883</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173</idno>
<idno type="RBID">PMC:2939173</idno>
<idno type="wicri:Area/Pmc/Corpus">000091</idno>
<idno type="wicri:Area/Pmc/Curation">000091</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000332</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001809</idno>
<idno type="wicri:Area/PubMed/Curation">001809</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001791</idno>
<idno type="wicri:Area/Ncbi/Merge">002B93</idno>
<idno type="wicri:Area/Ncbi/Curation">002B93</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002B93</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:Area/Main/Merge">002040</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0446321</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000912</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002407</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000977</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:Area/Main/Merge">002564</idno>
<idno type="wicri:Area/Main/Curation">001C04</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-09-15">2010-09-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="1944">1944</biblScope>
<biblScope unit="page" to="1952">1952</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</idno>
<idno type="DOI">10.1002/mds.23169</idno>
<idno type="ArticleID">MDS23169</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Ataxia</term>
<term>Cerebellar Diseases (physiopathology)</term>
<term>Cerebellar disease</term>
<term>Cerebellum</term>
<term>Cerebellum (injuries)</term>
<term>Cerebellum (physiopathology)</term>
<term>Gait</term>
<term>Gait Ataxia (physiopathology)</term>
<term>Humans</term>
<term>ICARS</term>
<term>Nervous system diseases</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Sensitivity</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>Tracking</term>
<term>Walking</term>
<term>ataxia</term>
<term>cerebellum</term>
<term>clinical assessment</term>
<term>sensitivity</term>
<term>walking</term>
</keywords>
<keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term>
<term>Cerebellum</term>
<term>Gait Ataxia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Gait</term>
<term>Humans</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ataxie</term>
<term>Cervelet</term>
<term>Marche à pied</term>
<term>Pathologie du système nerveux</term>
<term>Pathologie du cervelet</term>
<term>Pistage</term>
<term>Sensibilité</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2010:Morton S:longitudinal:tracking:of"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine</s1>
<s2>Iowa City, Iowa</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Physical Therapy, Temple University</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Kennedy Krieger Institute</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Program in Physical Therapy, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Kennedy Krieger Institute</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0446321</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0446321 INIST</idno>
<idno type="RBID">Pascal:10-0446321</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000912</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002407</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000977</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:Area/Main/Merge">002564</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine</s1>
<s2>Iowa City, Iowa</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Physical Therapy, Temple University</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Kennedy Krieger Institute</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Program in Physical Therapy, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Kennedy Krieger Institute</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ataxia</term>
<term>Cerebellar disease</term>
<term>Cerebellum</term>
<term>Nervous system diseases</term>
<term>Sensitivity</term>
<term>Tracking</term>
<term>Walking</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du cervelet</term>
<term>Ataxie</term>
<term>Pathologie du système nerveux</term>
<term>Pistage</term>
<term>Cervelet</term>
<term>Marche à pied</term>
<term>Sensibilité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
</author>
<author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23169</idno>
<idno type="url">https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C10</idno>
<idno type="wicri:Area/Istex/Curation">000C10</idno>
<idno type="wicri:Area/Istex/Checkpoint">000883</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173</idno>
<idno type="RBID">PMC:2939173</idno>
<idno type="wicri:Area/Pmc/Corpus">000091</idno>
<idno type="wicri:Area/Pmc/Curation">000091</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000332</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001809</idno>
<idno type="wicri:Area/PubMed/Curation">001809</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001791</idno>
<idno type="wicri:Area/Ncbi/Merge">002B93</idno>
<idno type="wicri:Area/Ncbi/Curation">002B93</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002B93</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno>
<idno type="wicri:Area/Main/Merge">002040</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-09-15">2010-09-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="1944">1944</biblScope>
<biblScope unit="page" to="1952">1952</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</idno>
<idno type="DOI">10.1002/mds.23169</idno>
<idno type="ArticleID">MDS23169</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Cerebellar Diseases (physiopathology)</term>
<term>Cerebellum (injuries)</term>
<term>Cerebellum (physiopathology)</term>
<term>Gait</term>
<term>Gait Ataxia (physiopathology)</term>
<term>Humans</term>
<term>ICARS</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
<term>ataxia</term>
<term>cerebellum</term>
<term>clinical assessment</term>
<term>sensitivity</term>
<term>walking</term>
</keywords>
<keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term>
<term>Cerebellum</term>
<term>Gait Ataxia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Gait</term>
<term>Humans</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001C04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0 |texte= Longitudinal tracking of gait and balance impairments in cerebellar disease }}
This area was generated with Dilib version V0.6.23. |