Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease
Identifieur interne : 002B93 ( Ncbi/Merge ); précédent : 002B92; suivant : 002B94Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease
Auteurs : Susanne M. Morton [États-Unis] ; Ya-Weng Tseng [États-Unis] ; Kathleen M. Zackowski [États-Unis] ; Jaclyn R. Daline [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- injuries : Cerebellum.
- physiopathology : Cerebellar Diseases, Cerebellum, Gait Ataxia.
- Analysis of Variance, Gait, Humans, Neurologic Examination, Postural Balance, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.
Url:
DOI: 10.1002/mds.23169
PubMed: 20544808
PubMed Central: 2939173
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PMC:2939173Le document en format XML
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<term>Cerebellum (physiopathology)</term>
<term>Gait</term>
<term>Gait Ataxia (physiopathology)</term>
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<term>Neurologic Examination</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</p>
</div>
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<front><div type="abstract" xml:lang="en"><p id="P1">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</p>
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<affiliation wicri:level="2"><nlm:affiliation>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M" last="Zackowski">Kathleen M. Zackowski</name>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R" last="Daline">Jaclyn R. Daline</name>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J" last="Bastian">Amy J. Bastian</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="doi">10.1002/mds.23169</idno>
<idno type="RBID">pubmed:20544808</idno>
<idno type="pmid">20544808</idno>
<idno type="wicri:Area/PubMed/Corpus">001809</idno>
<idno type="wicri:Area/PubMed/Curation">001809</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001791</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease.</title>
<author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M" last="Morton">Susanne M. Morton</name>
<affiliation wicri:level="2"><nlm:affiliation>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
</author>
<author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M" last="Zackowski">Kathleen M. Zackowski</name>
</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R" last="Daline">Jaclyn R. Daline</name>
</author>
<author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J" last="Bastian">Amy J. Bastian</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Cerebellar Diseases (physiopathology)</term>
<term>Cerebellum (injuries)</term>
<term>Cerebellum (physiopathology)</term>
<term>Gait</term>
<term>Gait Ataxia (physiopathology)</term>
<term>Humans</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term>
<term>Cerebellum</term>
<term>Gait Ataxia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Gait</term>
<term>Humans</term>
<term>Neurologic Examination</term>
<term>Postural Balance</term>
<term>Severity of Illness Index</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
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