Longitudinal tracking of gait and balance impairments in cerebellar disease
Identifieur interne : 000C10 ( Istex/Corpus ); précédent : 000C09; suivant : 000C11Longitudinal tracking of gait and balance impairments in cerebellar disease
Auteurs : Susanne M. Morton ; Ya-Weng Tseng ; Kathleen M. Zackowski ; Jaclyn R. Daline ; Amy J. BastianSource :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
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Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23169
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ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0Le document en format XML
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Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. 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Broadway, Room G‐04, Baltimore, MD 21205</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23169.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="6406"></count></countGroup><titleGroup><title type="main" xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Longitudinal Tracking of Cerebellar Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Susanne M.</givenNames><familyName>Morton</familyName><degrees>PhD, PT</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Ya‐Weng</givenNames><familyName>Tseng</familyName><degrees>PhD, PT</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Kathleen M.</givenNames><familyName>Zackowski</familyName><degrees>PhD, OTR</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Jaclyn R.</givenNames><familyName>Daline</familyName><degrees>PT, DPT</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3 #af4 #af5" corresponding="yes"><personName><givenNames>Amy J.</givenNames><familyName>Bastian</familyName><degrees>PhD, PT</degrees></personName><contactDetails><email>bastian@kennedykrieger.org</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Kennedy Krieger Institute, Baltimore, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">ICARS</keyword><keyword xml:id="kwd2">cerebellum</keyword><keyword xml:id="kwd3">walking</keyword><keyword xml:id="kwd4">ataxia</keyword><keyword xml:id="kwd5">clinical assessment</keyword><keyword xml:id="kwd6">sensitivity</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency></fundingInfo><fundingInfo><fundingAgency>(NICHD/NCMRR)</fundingAgency><fundingNumber>grants K01 HD050369</fundingNumber><fundingNumber>K01 HD049476</fundingNumber><fundingNumber>K12 HD055931</fundingNumber><fundingNumber>R01 HD040289</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Foundation for Physical Therapy</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Longitudinal tracking of gait and balance impairments in cerebellar disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Longitudinal Tracking of Cerebellar Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Longitudinal tracking of gait and balance impairments in cerebellar disease</title></titleInfo><name type="personal"><namePart type="given">Susanne M.</namePart><namePart type="family">Morton</namePart><namePart type="termsOfAddress">PhD, PT</namePart><affiliation>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ya‐Weng</namePart><namePart type="family">Tseng</namePart><namePart type="termsOfAddress">PhD, PT</namePart><affiliation>Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathleen M.</namePart><namePart type="family">Zackowski</namePart><namePart type="termsOfAddress">PhD, OTR</namePart><affiliation>Kennedy Krieger Institute, Baltimore, Maryland, USA</affiliation><affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><affiliation>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaclyn R.</namePart><namePart type="family">Daline</namePart><namePart type="termsOfAddress">PT, DPT</namePart><affiliation>Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amy J.</namePart><namePart type="family">Bastian</namePart><namePart type="termsOfAddress">PhD, PT</namePart><affiliation>Kennedy Krieger Institute, Baltimore, Maryland, USA</affiliation><affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><affiliation>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</affiliation><description>Correspondence: Kennedy Krieger Institute, 707 N. Broadway, Room G‐04, Baltimore, MD 21205</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-09-15</dateIssued><dateCaptured encoding="w3cdtf">2009-08-26</dateCaptured><dateValid encoding="w3cdtf">2010-03-16</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">36</extent><extent unit="words">6406</extent></physicalDescription><abstract lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">NIH</note><note type="funding">(NICHD/NCMRR) - No. grants K01 HD050369; No. K01 HD049476; No. K12 HD055931; No. R01 HD040289; </note><note type="funding">Foundation for Physical Therapy</note><subject lang="en"><genre>Keywords</genre><topic>ICARS</topic><topic>cerebellum</topic><topic>walking</topic><topic>ataxia</topic><topic>clinical assessment</topic><topic>sensitivity</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1944</start><end>1952</end><total>9</total></extent></part></relatedItem><identifier type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</identifier><identifier type="DOI">10.1002/mds.23169</identifier><identifier type="ArticleID">MDS23169</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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