Longitudinal tracking of gait and balance impairments in cerebellar disease
Identifieur interne : 002040 ( Main/Merge ); précédent : 002039; suivant : 002041Longitudinal tracking of gait and balance impairments in cerebellar disease
Auteurs : Susanne M. Morton [États-Unis] ; Ya-Weng Tseng [États-Unis] ; Kathleen M. Zackowski [États-Unis] ; Jaclyn R. Daline [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
- Analysis of Variance, Cerebellar Diseases (physiopathology), Cerebellum (injuries), Cerebellum (physiopathology), Gait, Gait Ataxia (physiopathology), Humans, ICARS, Neurologic Examination, Postural Balance, Severity of Illness Index, Statistics, Nonparametric, ataxia, cerebellum, clinical assessment, sensitivity, walking.
- MESH :
- injuries : Cerebellum.
- physiopathology : Cerebellar Diseases, Cerebellum, Gait Ataxia.
- Analysis of Variance, Gait, Humans, Neurologic Examination, Postural Balance, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173
DOI: 10.1002/mds.23169
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Bastian</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1944">1944</biblScope><biblScope unit="page" to="1952">1952</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</idno><idno type="DOI">10.1002/mds.23169</idno><idno type="ArticleID">MDS23169</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Cerebellar Diseases (physiopathology)</term><term>Cerebellum (injuries)</term><term>Cerebellum (physiopathology)</term><term>Gait</term><term>Gait Ataxia (physiopathology)</term><term>Humans</term><term>ICARS</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term><term>ataxia</term><term>cerebellum</term><term>clinical assessment</term><term>sensitivity</term><term>walking</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term><term>Cerebellum</term><term>Gait Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Gait</term><term>Humans</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23169"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title><author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name></author><author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name></author><author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name></author><author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name></author><author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A488BA0B8496C7485584B370075B9669EAC69AC0</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23169</idno><idno type="url">https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C10</idno><idno type="wicri:Area/Istex/Curation">000C10</idno><idno type="wicri:Area/Istex/Checkpoint">000883</idno><idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Longitudinal tracking of gait and balance impairments in cerebellar disease</title><author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kennedy Krieger Institute, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1944">1944</biblScope><biblScope unit="page" to="1952">1952</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</idno><idno type="DOI">10.1002/mds.23169</idno><idno type="ArticleID">MDS23169</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ICARS</term><term>ataxia</term><term>cerebellum</term><term>clinical assessment</term><term>sensitivity</term><term>walking</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</title><author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name><affiliation wicri:level="2"><nlm:aff id="A1"> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Physical Therapy, Temple University, Philadelphia, PA 19140</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea> Department of Physical Therapy, Temple University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><affiliation wicri:level="2"><nlm:aff id="A3"> Kennedy Krieger Institute, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Kennedy Krieger Institute, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name><affiliation wicri:level="2"><nlm:aff id="A6"> Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea> Program in Physical Therapy, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><affiliation wicri:level="2"><nlm:aff id="A3"> Kennedy Krieger Institute, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Kennedy Krieger Institute, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20544808</idno><idno type="pmc">2939173</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173</idno><idno type="RBID">PMC:2939173</idno><idno type="doi">10.1002/mds.23169</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000091</idno><idno type="wicri:Area/Pmc/Curation">000091</idno><idno type="wicri:Area/Pmc/Checkpoint">000332</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001809</idno><idno type="wicri:Area/PubMed/Curation">001809</idno><idno type="wicri:Area/PubMed/Checkpoint">001791</idno><idno type="wicri:Area/Ncbi/Merge">002B93</idno><idno type="wicri:Area/Ncbi/Curation">002B93</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B93</idno><idno type="wicri:doubleKey">0885-3185:2010:Morton S:longitudinal:tracking:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</title><author><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name><affiliation wicri:level="2"><nlm:aff id="A1"> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Physical Therapy, Temple University, Philadelphia, PA 19140</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea> Department of Physical Therapy, Temple University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><affiliation wicri:level="2"><nlm:aff id="A3"> Kennedy Krieger Institute, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Kennedy Krieger Institute, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name><affiliation wicri:level="2"><nlm:aff id="A6"> Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea> Program in Physical Therapy, Washington University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><affiliation wicri:level="2"><nlm:aff id="A3"> Kennedy Krieger Institute, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Kennedy Krieger Institute, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Cerebellar Diseases (physiopathology)</term><term>Cerebellum (injuries)</term><term>Cerebellum (physiopathology)</term><term>Gait</term><term>Gait Ataxia (physiopathology)</term><term>Humans</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term><term>Cerebellum</term><term>Gait Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Gait</term><term>Humans</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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