Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease
Identifieur interne : 000332 ( Pmc/Checkpoint ); précédent : 000331; suivant : 000333Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease
Auteurs : Susanne M. Morton [États-Unis] ; Ya-Weng Tseng [États-Unis] ; Kathleen M. Zackowski [États-Unis] ; Jaclyn R. Daline [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.
Url:
DOI: 10.1002/mds.23169
PubMed: 20544808
PubMed Central: 2939173
Affiliations:
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Morton</name><affiliation wicri:level="2"><nlm:aff id="A1"> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Physical Therapy, Temple University, Philadelphia, PA 19140</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea> Department of Physical Therapy, Temple University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. 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Zackowski</name><affiliation wicri:level="2"><nlm:aff id="A3"> Kennedy Krieger Institute, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Kennedy Krieger Institute, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. 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Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20544808</article-id><article-id pub-id-type="pmc">2939173</article-id><article-id pub-id-type="doi">10.1002/mds.23169</article-id><article-id pub-id-type="manuscript">NIHMS216487</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Morton</surname><given-names>Susanne M.</given-names></name><degrees>PhD, PT</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Ya-Weng</given-names></name><degrees>PhD, PT</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Zackowski</surname><given-names>Kathleen M.</given-names></name><degrees>PhD, OTR</degrees><xref rid="A3" ref-type="aff">3</xref><xref rid="A4" ref-type="aff">4</xref><xref rid="A5" ref-type="aff">5</xref></contrib><contrib contrib-type="author"><name><surname>Daline</surname><given-names>Jaclyn R.</given-names></name><degrees>PT, DPT</degrees><xref rid="A6" ref-type="aff">6</xref></contrib><contrib contrib-type="author"><name><surname>Bastian</surname><given-names>Amy J.</given-names></name><degrees>PhD, PT</degrees><xref rid="A3" ref-type="aff">3</xref><xref rid="A4" ref-type="aff">4</xref><xref rid="A5" ref-type="aff">5</xref></contrib></contrib-group><aff id="A1"><label>1</label> Graduate Program in Physical Therapy & Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City, IA 52242</aff><aff id="A2"><label>2</label> Department of Physical Therapy, Temple University, Philadelphia, PA 19140</aff><aff id="A3"><label>3</label> Kennedy Krieger Institute, Baltimore, MD 21205</aff><aff id="A4"><label>4</label> Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</aff><aff id="A5"><label>5</label> Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21205</aff><aff id="A6"><label>6</label> Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63108</aff><author-notes><corresp id="FN1">Corresponding Author: Dr. Amy J. Bastian, Kennedy Krieger Institute, 707 N. Broadway, Room G-04, Baltimore, MD 21205, TEL: 443-923-2718, FAX: 443-923-2715, <email>bastian@kennedykrieger.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>6</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>9</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>9</month><year>2011</year></pub-date><volume>25</volume><issue>12</issue><fpage>1944</fpage><lpage>1952</lpage><abstract><p id="P1">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over one year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over one year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</p></abstract><kwd-group><kwd>ICARS</kwd><kwd>cerebellum</kwd><kwd>walking</kwd><kwd>ataxia</kwd><kwd>clinical assessment</kwd><kwd>sensitivity</kwd></kwd-group><contract-num rid="HD1">R01 HD040289-09
||HD</contract-num><contract-num rid="HD1">K01 HD050369-05
||HD</contract-num><contract-sponsor id="HD1">National Institute of Child Health & Human Development : NICHD</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li><li>Maryland</li><li>Missouri (État)</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name></region><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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