MovDisordV3, PascalFrancis, Corpus, bibRecord, 000912

Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease

Identifieur interne : 000912 ( PascalFrancis/Corpus ); précédent : 000911; suivant : 000913

Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease

Auteurs : Susanne M. Morton ; Ya-Weng Tseng ; Kathleen M. Zackowski ; Jaclyn R. Daline ; Amy J. Bastian

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0446321

Descripteurs français

Pascal (Inist)
- Pathologie du cervelet, Ataxie, Pathologie du système nerveux, Pistage, Cervelet, Marche à pied, Sensibilité.

English descriptors

KwdEn :
- Ataxia, Cerebellar disease, Cerebellum, Nervous system diseases, Sensitivity, Tracking, Walking.

Abstract

Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 MORTON (Susanne M.)`
A11	`02`	`1`		`@1 TSENG (Ya-Weng)`
A11	`03`	`1`		`@1 ZACKOWSKI (Kathleen M.)`
A11	`04`	`1`		`@1 DALINE (Jaclyn R.)`
A11	`05`	`1`		`@1 BASTIAN (Amy J.)`
A14	`01`			`@1 Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine @2 Iowa City, Iowa @3 USA @Z 1 aut.`
A14	`02`			`@1 Department of Physical Therapy, Temple University @2 Philadelphia, Pennsylvania @3 USA @Z 2 aut.`
A14	`03`			`@1 Kennedy Krieger Institute @2 Baltimore, Maryland @3 USA @Z 3 aut. @Z 5 aut.`
A14	`04`			`@1 Department of Neurology, Johns Hopkins University School of Medicine @2 Baltimore, Maryland @3 USA @Z 3 aut. @Z 5 aut.`
A14	`05`			`@1 Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine @2 Baltimore, Maryland @3 USA @Z 3 aut. @Z 5 aut.`
A14	`06`			`@1 Program in Physical Therapy, Washington University School of Medicine @2 St. Louis, Missouri @3 USA @Z 4 aut.`
A20				`@1 1944-1952`
A21				`@1 2010`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 36 ref.`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Pathologie du cervelet @5 01`
C03	`01`	`X`	`ENG`	`@0 Cerebellar disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Cerebelar enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Ataxie @5 02`
C03	`02`	`X`	`ENG`	`@0 Ataxia @5 02`
C03	`02`	`X`	`SPA`	`@0 Ataxia @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Pistage @5 09`
C03	`04`	`X`	`ENG`	`@0 Tracking @5 09`
C03	`04`	`X`	`SPA`	`@0 Rastreo @5 09`
C03	`05`	`X`	`FRE`	`@0 Cervelet @5 10`
C03	`05`	`X`	`ENG`	`@0 Cerebellum @5 10`
C03	`05`	`X`	`SPA`	`@0 Cerebelo @5 10`
C03	`06`	`X`	`FRE`	`@0 Marche à pied @5 11`
C03	`06`	`X`	`ENG`	`@0 Walking @5 11`
C03	`06`	`X`	`SPA`	`@0 Caminata @5 11`
C03	`07`	`X`	`FRE`	`@0 Sensibilité @5 12`
C03	`07`	`X`	`ENG`	`@0 Sensitivity @5 12`
C03	`07`	`X`	`SPA`	`@0 Sensibilidad @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale @5 40`
C07	`03`	`X`	`ENG`	`@0 Encephalon @5 40`
C07	`03`	`X`	`SPA`	`@0 Encéfalo @5 40`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central @5 41`
C07	`04`	`X`	`ENG`	`@0 Central nervous system @5 41`
C07	`04`	`X`	`SPA`	`@0 Sistema nervioso central @5 41`
C07	`05`	`X`	`FRE`	`@0 Locomotion @5 42`
C07	`05`	`X`	`ENG`	`@0 Locomotion @5 42`
C07	`05`	`X`	`SPA`	`@0 Locomoción @5 42`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 43`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 43`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 43`
N21				`@1 291`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0446321 INIST
ET :	Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease
AU :	MORTON (Susanne M.); TSENG (Ya-Weng); ZACKOWSKI (Kathleen M.); DALINE (Jaclyn R.); BASTIAN (Amy J.)
AF :	Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine/Iowa City, Iowa/Etats-Unis (1 aut.); Department of Physical Therapy, Temple University/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Kennedy Krieger Institute/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Department of Neurology, Johns Hopkins University School of Medicine/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Program in Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 12; Pp. 1944-1952; Bibl. 36 ref.
LA :	Anglais
EA :	Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.
CC :	002B17; 002B17G
FD :	Pathologie du cervelet; Ataxie; Pathologie du système nerveux; Pistage; Cervelet; Marche à pied; Sensibilité
FG :	Pathologie de l'encéphale; Pathologie du système nerveux central; Encéphale; Système nerveux central; Locomotion; Trouble neurologique
ED :	Cerebellar disease; Ataxia; Nervous system diseases; Tracking; Cerebellum; Walking; Sensitivity
EG :	Cerebral disorder; Central nervous system disease; Encephalon; Central nervous system; Locomotion; Neurological disorder
SD :	Cerebelar enfermedad; Ataxia; Sistema nervioso patología; Rastreo; Cerebelo; Caminata; Sensibilidad
LO :	INIST-20953.354000194841700240
ID :	10-0446321

Links to Exploration step

Pascal:10-0446321

Le document en format XML

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<author><name sortKey="Tseng, Ya Weng" sort="Tseng, Ya Weng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name>
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</author>
<author><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du cervelet</term>
<term>Ataxie</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</div>
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<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Cerebellar disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Cerebelar enfermedad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Ataxie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Ataxia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Ataxia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pistage</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Tracking</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Rastreo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Cervelet</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Cerebellum</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Cerebelo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Marche à pied</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Walking</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Caminata</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Sensibilité</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Sensitivity</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Sensibilidad</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Locomotion</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Locomotion</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Locomoción</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>43</s5>
</fC07>
<fN21><s1>291</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0446321 INIST</NO>
<ET>Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease</ET>
<AU>MORTON (Susanne M.); TSENG (Ya-Weng); ZACKOWSKI (Kathleen M.); DALINE (Jaclyn R.); BASTIAN (Amy J.)</AU>
<AF>Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine/Iowa City, Iowa/Etats-Unis (1 aut.); Department of Physical Therapy, Temple University/Philadelphia, Pennsylvania/Etats-Unis (2 aut.); Kennedy Krieger Institute/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Department of Neurology, Johns Hopkins University School of Medicine/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine/Baltimore, Maryland/Etats-Unis (3 aut., 5 aut.); Program in Physical Therapy, Washington University School of Medicine/St. Louis, Missouri/Etats-Unis (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 12; Pp. 1944-1952; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long-term changes in gait and balance performance in individuals with cerebellar degenerative disorders.</EA>
<CC>002B17; 002B17G</CC>
<FD>Pathologie du cervelet; Ataxie; Pathologie du   système nerveux; Pistage; Cervelet; Marche à pied; Sensibilité</FD>
<FG>Pathologie de l'encéphale; Pathologie du   système nerveux central; Encéphale; Système nerveux central; Locomotion; Trouble neurologique</FG>
<ED>Cerebellar disease; Ataxia; Nervous system diseases; Tracking; Cerebellum; Walking; Sensitivity</ED>
<EG>Cerebral disorder; Central nervous system disease; Encephalon; Central nervous system; Locomotion; Neurological disorder</EG>
<SD>Cerebelar enfermedad; Ataxia; Sistema nervioso patología; Rastreo; Cerebelo; Caminata; Sensibilidad</SD>
<LO>INIST-20953.354000194841700240</LO>
<ID>10-0446321</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease

Longitudinal Tracking of Gait and Balance Impairments in Cerebellar Disease

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