In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Identifieur interne : 000578 ( Main/Exploration ); précédent : 000577; suivant : 000579In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Auteurs : Daniel Coman [États-Unis] ; Robin A. De Graaf [États-Unis] ; Douglas L. Rothman [États-Unis] ; Fahmeed Hyder [États-Unis]Source :
- NMR in Biomedicine [ 0952-3480 ] ; 2013-11.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Encéphale.
- Wicri :
English descriptors
- KwdEn :
- Acquisition time, Animals, Average temperatures, Biomed, Biosensing Techniques (methods), Biosensor imaging, Body Temperature, Brain (physiology), Brain temperature, Chemical shift, Chemical shift imaging, Coman, Copyright, Corpus callosum, Cubical, Cubical dataset, Cubical encoding, Data acquisition, Dataset, Datasets, Effective resolution, Effective volume, Effective voxel volume, Encoding, Encoding steps, Experimental time, Gaussian, Gaussian weighting, High spatiotemporal resolution, Hyder, Imaginary parts, Imaging, Imaging, Three-Dimensional (methods), John wiley sons, Lanthanide, Magn, Magnetic Resonance Imaging, Magnetic resonance, Molecular Imaging (methods), Molecular imaging, Nominal voxel volume, Nonexchanging protons, Normal Distribution, Organometallic Compounds, Phase encoding, Point spread function, Rats, Rats, Sprague-Dawley, Redundant deviation, Relaxation times, Resegaw, Resegaw dataset, Reson, Rothman, Sampling function, Signal intensity, Somatosensory stimulation, Spatial resolution, Spatio-Temporal Analysis, Spatiotemporal, Spectroscopic, Spectroscopic imaging, Spherical encoding, Superior colliculus, Surface coil, Temporal resolution, Tmdotma, Total signal, Trubel, Voxel, Weighting, Window function, Yale university.
- MESH :
- chemical : Organometallic Compounds.
- methods : Biosensing Techniques, Imaging, Three-Dimensional, Molecular Imaging.
- physiology : Brain.
- Teeft :
- Acquisition time, Animals, Average temperatures, Biomed, Biosensor imaging, Body Temperature, Brain temperature, Chemical shift, Chemical shift imaging, Coman, Copyright, Corpus callosum, Cubical, Cubical dataset, Cubical encoding, Data acquisition, Dataset, Datasets, Effective resolution, Effective volume, Effective voxel volume, Encoding, Encoding steps, Experimental time, Gaussian, Gaussian weighting, High spatiotemporal resolution, Hyder, Imaginary parts, Imaging, John wiley sons, Lanthanide, Magn, Magnetic Resonance Imaging, Magnetic resonance, Molecular imaging, Nominal voxel volume, Nonexchanging protons, Normal Distribution, Phase encoding, Point spread function, Rats, Rats, Sprague-Dawley, Redundant deviation, Relaxation times, Resegaw, Resegaw dataset, Reson, Rothman, Sampling function, Signal intensity, Somatosensory stimulation, Spatial resolution, Spatio-Temporal Analysis, Spatiotemporal, Spectroscopic, Spectroscopic imaging, Spherical encoding, Superior colliculus, Surface coil, Temporal resolution, Tmdotma, Total signal, Trubel, Voxel, Weighting, Window function, Yale university.
Abstract
Spectroscopic signals which emanate from complexes between paramagnetic lanthanide (III) ions (e.g. Tm3+) and macrocyclic chelates (e.g. 1,4,7,10‐tetramethyl‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate, or DOTMA4–) are sensitive to physiology (e.g. temperature). Because nonexchanging protons from these lanthanide‐based macrocyclic agents have relaxation times on the order of a few milliseconds, rapid data acquisition is possible with chemical shift imaging (CSI). Thus, Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) which originate from nonexchanging protons of these paramagnetic agents, but exclude water proton detection, can allow molecular imaging. Previous two‐dimensional CSI experiments with such lanthanide‐based macrocyclics allowed acquisition from ~12‐μL voxels in rat brain within 5 min using rectangular encoding of k space. Because cubical encoding of k space in three dimensions for whole‐brain coverage increases the CSI acquisition time to several tens of minutes or more, a faster CSI technique is required for BIRDS to be of practical use. Here, we demonstrate a CSI acquisition method to improve three‐dimensional molecular imaging capabilities with lanthanide‐based macrocyclics. Using TmDOTMA–, we show datasets from a 20 × 20 × 20‐mm3 field of view with voxels of ~1 μL effective volume acquired within 5 min (at 11.7 T) for temperature mapping. By employing reduced spherical encoding with Gaussian weighting (RESEGAW) instead of cubical encoding of k space, a significant increase in CSI signal is obtained. In vitro and in vivo three‐dimensional CSI data with TmDOTMA–, and presumably similar lanthanide‐based macrocyclics, suggest that acquisition using RESEGAW can be used for high spatiotemporal resolution molecular mapping with BIRDS. Copyright © 2013 John Wiley & Sons, Ltd.
Url:
- https://api.istex.fr/document/DECA4C899D3CCF4703BFC9CC4DFF8A80450FB1A7/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800475
DOI: 10.1002/nbm.2995
Affiliations:
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type="ISSN">0952-3480</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0952-3480</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acquisition time</term><term>Animals</term><term>Average temperatures</term><term>Biomed</term><term>Biosensing Techniques (methods)</term><term>Biosensor imaging</term><term>Body Temperature</term><term>Brain (physiology)</term><term>Brain temperature</term><term>Chemical shift</term><term>Chemical shift imaging</term><term>Coman</term><term>Copyright</term><term>Corpus callosum</term><term>Cubical</term><term>Cubical dataset</term><term>Cubical encoding</term><term>Data acquisition</term><term>Dataset</term><term>Datasets</term><term>Effective resolution</term><term>Effective volume</term><term>Effective voxel volume</term><term>Encoding</term><term>Encoding steps</term><term>Experimental time</term><term>Gaussian</term><term>Gaussian weighting</term><term>High spatiotemporal resolution</term><term>Hyder</term><term>Imaginary parts</term><term>Imaging</term><term>Imaging, Three-Dimensional (methods)</term><term>John wiley sons</term><term>Lanthanide</term><term>Magn</term><term>Magnetic Resonance Imaging</term><term>Magnetic resonance</term><term>Molecular Imaging (methods)</term><term>Molecular imaging</term><term>Nominal voxel volume</term><term>Nonexchanging protons</term><term>Normal Distribution</term><term>Organometallic Compounds</term><term>Phase encoding</term><term>Point spread function</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Redundant deviation</term><term>Relaxation times</term><term>Resegaw</term><term>Resegaw dataset</term><term>Reson</term><term>Rothman</term><term>Sampling function</term><term>Signal intensity</term><term>Somatosensory stimulation</term><term>Spatial resolution</term><term>Spatio-Temporal Analysis</term><term>Spatiotemporal</term><term>Spectroscopic</term><term>Spectroscopic imaging</term><term>Spherical encoding</term><term>Superior colliculus</term><term>Surface coil</term><term>Temporal resolution</term><term>Tmdotma</term><term>Total signal</term><term>Trubel</term><term>Voxel</term><term>Weighting</term><term>Window function</term><term>Yale university</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse spatio-temporelle</term><term>Animaux</term><term>Composés organométalliques</term><term>Encéphale (physiologie)</term><term>Imagerie moléculaire ()</term><term>Imagerie par résonance magnétique</term><term>Imagerie tridimensionnelle ()</term><term>Loi normale</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Techniques de biocapteur ()</term><term>Température du corps</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biosensing Techniques</term><term>Imaging, Three-Dimensional</term><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acquisition time</term><term>Animals</term><term>Average temperatures</term><term>Biomed</term><term>Biosensor imaging</term><term>Body Temperature</term><term>Brain temperature</term><term>Chemical shift</term><term>Chemical shift imaging</term><term>Coman</term><term>Copyright</term><term>Corpus callosum</term><term>Cubical</term><term>Cubical dataset</term><term>Cubical encoding</term><term>Data acquisition</term><term>Dataset</term><term>Datasets</term><term>Effective resolution</term><term>Effective volume</term><term>Effective voxel volume</term><term>Encoding</term><term>Encoding steps</term><term>Experimental time</term><term>Gaussian</term><term>Gaussian weighting</term><term>High spatiotemporal resolution</term><term>Hyder</term><term>Imaginary parts</term><term>Imaging</term><term>John wiley sons</term><term>Lanthanide</term><term>Magn</term><term>Magnetic Resonance Imaging</term><term>Magnetic resonance</term><term>Molecular imaging</term><term>Nominal voxel volume</term><term>Nonexchanging protons</term><term>Normal Distribution</term><term>Phase encoding</term><term>Point spread function</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Redundant deviation</term><term>Relaxation times</term><term>Resegaw</term><term>Resegaw dataset</term><term>Reson</term><term>Rothman</term><term>Sampling function</term><term>Signal intensity</term><term>Somatosensory stimulation</term><term>Spatial resolution</term><term>Spatio-Temporal Analysis</term><term>Spatiotemporal</term><term>Spectroscopic</term><term>Spectroscopic imaging</term><term>Spherical encoding</term><term>Superior colliculus</term><term>Surface coil</term><term>Temporal resolution</term><term>Tmdotma</term><term>Total signal</term><term>Trubel</term><term>Voxel</term><term>Weighting</term><term>Window function</term><term>Yale university</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse spatio-temporelle</term><term>Animaux</term><term>Composés organométalliques</term><term>Droit d'auteur</term><term>Imagerie moléculaire</term><term>Imagerie par résonance magnétique</term><term>Imagerie tridimensionnelle</term><term>Loi normale</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Techniques de biocapteur</term><term>Température du corps</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Spectroscopic signals which emanate from complexes between paramagnetic lanthanide (III) ions (e.g. Tm3+) and macrocyclic chelates (e.g. 1,4,7,10‐tetramethyl‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate, or DOTMA4–) are sensitive to physiology (e.g. temperature). Because nonexchanging protons from these lanthanide‐based macrocyclic agents have relaxation times on the order of a few milliseconds, rapid data acquisition is possible with chemical shift imaging (CSI). Thus, Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) which originate from nonexchanging protons of these paramagnetic agents, but exclude water proton detection, can allow molecular imaging. Previous two‐dimensional CSI experiments with such lanthanide‐based macrocyclics allowed acquisition from ~12‐μL voxels in rat brain within 5 min using rectangular encoding of k space. Because cubical encoding of k space in three dimensions for whole‐brain coverage increases the CSI acquisition time to several tens of minutes or more, a faster CSI technique is required for BIRDS to be of practical use. Here, we demonstrate a CSI acquisition method to improve three‐dimensional molecular imaging capabilities with lanthanide‐based macrocyclics. Using TmDOTMA–, we show datasets from a 20 × 20 × 20‐mm3 field of view with voxels of ~1 μL effective volume acquired within 5 min (at 11.7 T) for temperature mapping. By employing reduced spherical encoding with Gaussian weighting (RESEGAW) instead of cubical encoding of k space, a significant increase in CSI signal is obtained. In vitro and in vivo three‐dimensional CSI data with TmDOTMA–, and presumably similar lanthanide‐based macrocyclics, suggest that acquisition using RESEGAW can be used for high spatiotemporal resolution molecular mapping with BIRDS. Copyright © 2013 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name></region><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="De Graaf, Robin A" sort="De Graaf, Robin A" uniqKey="De Graaf R" first="Robin A." last="De Graaf">Robin A. De Graaf</name><name sortKey="De Graaf, Robin A" sort="De Graaf, Robin A" uniqKey="De Graaf R" first="Robin A." last="De Graaf">Robin A. De Graaf</name><name sortKey="De Graaf, Robin A" sort="De Graaf, Robin A" uniqKey="De Graaf R" first="Robin A." last="De Graaf">Robin A. De Graaf</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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