In vivo 3D molecular imaging with BIRDS at high spatiotemporal resolution
Identifieur interne : 000713 ( Ncbi/Checkpoint ); précédent : 000712; suivant : 000714In vivo 3D molecular imaging with BIRDS at high spatiotemporal resolution
Auteurs : Daniel Coman [États-Unis] ; Robin A. De Graaf [États-Unis] ; Douglas L. Rothman [États-Unis] ; Fahmeed Hyder [États-Unis]Source :
- NMR in biomedicine [ 0952-3480 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Organometallic Compounds.
- methods : Biosensing Techniques, Imaging, Three-Dimensional, Molecular Imaging.
- physiology : Brain.
- Animals, Body Temperature, Magnetic Resonance Imaging, Normal Distribution, Rats, Rats, Sprague-Dawley, Spatio-Temporal Analysis.
Abstract
Spectroscopic signals which emanate from complexes between paramagnetic lanthanide III ions (e.g., Tm3+) and macrocyclic chelates (e.g., 1,4,7,10-tetramethyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate, or DOTMA4−) are sensitive to physiology (e.g., temperature and/or pH). Because non-exchanging protons from these lanthanide-based macrocyclic agents have relaxation times on the order of a few milliseconds, rapid data acquisition is possible with chemical shift imaging (CSI). Thus
Url:
DOI: 10.1002/nbm.2995
PubMed: 23881869
PubMed Central: 3800475
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">Spectroscopic signals which emanate from complexes between paramagnetic lanthanide III ions (e.g., Tm<sup>3+</sup>
) and macrocyclic chelates (e.g., 1,4,7,10-tetramethyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate, or DOTMA<sup>4−</sup>
) are sensitive to physiology (e.g., temperature and/or pH). Because non-exchanging protons from these lanthanide-based macrocyclic agents have relaxation times on the order of a few milliseconds, rapid data acquisition is possible with chemical shift imaging (CSI). Thus <italic><bold>B</bold>
</italic>
iosensor <italic><bold>I</bold>
</italic>
maging of <italic><bold>R</bold>
</italic>
edundant <italic><bold>D</bold>
</italic>
eviation in <italic><bold>S</bold>
</italic>
hifts (BIRDS) which originate from non-exchanging protons of these paramagnetic agents, but exclude water proton detection, can allow molecular imaging. Previous 2D CSI experiments with such lanthanide-based macrocyclics allowed acquisition from ~12 µL voxels in rat brain within 5 minutes using rectangular encoding of k-space. Because cubical encoding of k-space in 3D for whole brain coverage increases CSI acquisition time to several tens of minutes or more, a faster CSI technique is required for BIRDS to be of practical use. Here we demonstrate a CSI acquisition method to improve 3D molecular imaging capabilities with lanthanide-based macrocyclics. Using TmDOTMA<sup>−</sup>
, we show datasets from a 20×20×20 mm<sup>3</sup>
field-of-view with voxels of ~1 µL effective volume acquired within 5 minutes (at 11.7T) for temperature mapping. By employing <bold>re</bold>
duced <bold>s</bold>
pherical <bold>e</bold>
ncoding with <bold>Ga</bold>
ussian <bold>w</bold>
eighting (RESEGAW) instead of cubical encoding of k-space, a significant increase in CSI signal is obtained. <italic>In vitro</italic>
and <italic>in vivo</italic>
3D CSI data with TmDOTMA<sup>−</sup>
, and presumably similar lanthanide-based macrocyclics, suggest that acquisition using RESEGAW can be used for high spatiotemporal molecular mapping with BIRDS.</p>
</div>
</front>
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<name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name>
<name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name>
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