Detection of four human coronaviruses in respiratory infections in children: A one‐year study in Colorado
Identifieur interne : 002E27 ( Main/Exploration ); précédent : 002E26; suivant : 002E28Detection of four human coronaviruses in respiratory infections in children: A one‐year study in Colorado
Auteurs : Samuel R. Dominguez [États-Unis] ; Christine C. Robinson [États-Unis] ; Kathryn V. Holmes [États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2009-09.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adolescent, Colorado (épidémiologie), Coronavirus (), Coronavirus (isolement et purification), Enfant, Enfant d'âge préscolaire, Femelle, Hospitalisation, Humains, Infections de l'appareil respiratoire (anatomopathologie), Infections de l'appareil respiratoire (physiopathologie), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections à coronavirus (anatomopathologie), Infections à coronavirus (diagnostic), Infections à coronavirus (physiopathologie), Infections à coronavirus (épidémiologie), Mâle, Nourrisson, Nouveau-né, RT-PCR (), Saisons.
- MESH :
- anatomopathologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- diagnostic : Infections à coronavirus.
- génétique : ARN viral.
- isolement et purification : Coronavirus.
- physiopathologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- virologie : Infections de l'appareil respiratoire.
- épidémiologie : Colorado, Infections de l'appareil respiratoire, Infections à coronavirus.
- Pascal (Inist)
- MESH :
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Colorado, Colorado (epidemiology), Coronavirus, Coronavirus (classification), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (pathology), Coronavirus Infections (physiopathology), Detection, Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, RNA, Viral (genetics), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (pathology), Respiratory Tract Infections (physiopathology), Respiratory Tract Infections (virology), Respiratory disease, Reverse Transcriptase Polymerase Chain Reaction (methods), Rhinovirus, Seasons, Viral disease.
- MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : Colorado.
- classification : Coronavirus.
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Respiratory Tract Infections.
- isolation & purification : Coronavirus.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- pathology : Coronavirus Infections, Respiratory Tract Infections.
- physiopathology : Coronavirus Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Teeft :
- Acute life, Adolescent, Antibiotics albuterol steroids, Assay, Care unit, Chest fever hypoxia, Child, Child, Preschool, Clin, Clin microbiol, Clinical associations, Clinical characteristics, Clinical features, Clinical presentation, Clinical presentations, Colorado denver school, Coronavirus, Coronavirus hku1, Coronavirus infections, Coronaviruses, Diagnostic virology laboratory, Different hcovs, Dominguez, Emergency department, Enteric, Enteric disease, Febrile seizures, Female, Gastrointestinal symptoms, Gerna, Grant number, Grant sponsor, Hcov, Hcov infections, Hcovs, Healthy children, Hoek, Hong kong, Hospitalization, Hrvs, Human bocavirus, Human coronavirus, Human coronavirus infections, Human coronaviruses, Human rhinovirus, Humans, Immunocompromised, Immunocompromised patients, Infant, Infant, Newborn, Infection, Kuypers, Large number, Lrti, Lrtis, Male, Nervous system, Novel coronavirus, Npws, Nucleocapsid gene, Other coronavirus infections, Picu, Positive samples, Potential roles, Respiratory infections, Respiratory specimens, Respiratory symptoms, Respiratory syndrome, Respiratory tract disease, Respiratory tract infections, Respiratory viruses, Retractions cough rhinorrhea congestion conjunctivitis pharyngitis rash, Rhinorrhea, Rhinovirus, Same time period, Seasons, Sensitive assays, Souza luna, Supplemental table, Tract illness, Tract infection, Tract symptoms, Urti symptoms, Vabret, Virol, Virology, Virus type, Wilcoxon test, Winter months, World health organization, Young children.
Abstract
Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non‐SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1‐year period (December 2004–November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT‐PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV‐NL63 in 37 specimens, HCoV‐OC43 in 34, HCoV‐229E in 11, and HCoV‐HKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty‐six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV‐229E RNA for 3 months. HCoV‐NL63‐positive patients were nearly twice as likely to be hospitalized (P = 0.02) and to have a LRTI (P = 0.04) than HCoV‐OC43‐positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol. 81:1597–1604, 2009. © 2009 Wiley‐Liss, Inc.
Url:
- https://api.istex.fr/ark:/67375/WNG-0F654RF3-M/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879166
DOI: 10.1002/jmv.21541
Affiliations:
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<front><div type="abstract" xml:lang="en">Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non‐SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1‐year period (December 2004–November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT‐PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV‐NL63 in 37 specimens, HCoV‐OC43 in 34, HCoV‐229E in 11, and HCoV‐HKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty‐six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV‐229E RNA for 3 months. HCoV‐NL63‐positive patients were nearly twice as likely to be hospitalized (P = 0.02) and to have a LRTI (P = 0.04) than HCoV‐OC43‐positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol. 81:1597–1604, 2009. © 2009 Wiley‐Liss, Inc.</div>
</front>
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