Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado.
Identifieur interne : 001859 ( PubMed/Corpus ); précédent : 001858; suivant : 001860Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado.
Auteurs : Samuel R. Dominguez ; Christine C. Robinson ; Kathryn V. HolmesSource :
- Journal of medical virology [ 1096-9071 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Colorado (epidemiology), Coronavirus (classification), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (pathology), Coronavirus Infections (physiopathology), Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, RNA, Viral (genetics), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (pathology), Respiratory Tract Infections (physiopathology), Respiratory Tract Infections (virology), Reverse Transcriptase Polymerase Chain Reaction (methods), Seasons.
- MESH :
- chemical , genetics : RNA, Viral.
- geographic , epidemiology : Colorado.
- classification : Coronavirus.
- diagnosis : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Respiratory Tract Infections.
- isolation & purification : Coronavirus.
- methods : Reverse Transcriptase Polymerase Chain Reaction.
- pathology : Coronavirus Infections, Respiratory Tract Infections.
- physiopathology : Coronavirus Infections, Respiratory Tract Infections.
- virology : Respiratory Tract Infections.
- Adolescent, Child, Child, Preschool, Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, Seasons.
Abstract
Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoV-HKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P = 0.02) and to have a LRTI (P = 0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases.
DOI: 10.1002/jmv.21541
PubMed: 19626607
Links to Exploration step
pubmed:19626607Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado.</title><author><name sortKey="Dominguez, Samuel R" sort="Dominguez, Samuel R" uniqKey="Dominguez S" first="Samuel R" last="Dominguez">Samuel R. Dominguez</name><affiliation><nlm:affiliation>Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. samuel.dominguez@ucdenver.edu</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Christine C" sort="Robinson, Christine C" uniqKey="Robinson C" first="Christine C" last="Robinson">Christine C. Robinson</name></author><author><name sortKey="Holmes, Kathryn V" sort="Holmes, Kathryn V" uniqKey="Holmes K" first="Kathryn V" last="Holmes">Kathryn V. 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Holmes</name></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Colorado (epidemiology)</term><term>Coronavirus (classification)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (physiopathology)</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>RNA, Viral (genetics)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (pathology)</term><term>Respiratory Tract Infections (physiopathology)</term><term>Respiratory Tract Infections (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction (methods)</term><term>Seasons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Colorado</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Seasons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoV-HKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P = 0.02) and to have a LRTI (P = 0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19626607</PMID><DateCompleted><Year>2009</Year><Month>09</Month><Day>21</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><Volume>81</Volume><Issue>9</Issue><PubDate><Year>2009</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado.</ArticleTitle><Pagination><MedlinePgn>1597-604</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.21541</ELocationID><Abstract><AbstractText>Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoV-HKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P = 0.02) and to have a LRTI (P = 0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. 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