Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado
Identifieur interne : 000798 ( PascalFrancis/Curation ); précédent : 000797; suivant : 000799Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado
Auteurs : Samuel R. Dominguez [États-Unis] ; Christine C. Robinson [États-Unis] ; Kathryn V. Holmes [États-Unis]Source :
- Journal of medical virology [ 0146-6615 ] ; 2009.
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Abstract
Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado</title><author><name sortKey="Dominguez, Samuel R" sort="Dominguez, Samuel R" uniqKey="Dominguez S" first="Samuel R." last="Dominguez">Samuel R. Dominguez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine</s1><s2>Aurora, Colorado</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Robinson, Christine C" sort="Robinson, Christine C" uniqKey="Robinson C" first="Christine C." last="Robinson">Christine C. Robinson</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology and Laboratory Medicine, The Children's Hospital, University of Colorado Denver School of Medicine</s1><s2>Aurora, Colorado</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Holmes, Kathryn V" sort="Holmes, Kathryn V" uniqKey="Holmes K" first="Kathryn V." last="Holmes">Kathryn V. Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, University of Colorado Denver School of Medicine</s1><s2>Aurora, Colorado</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0379754</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0379754 INIST</idno><idno type="RBID">Pascal:09-0379754</idno><idno type="wicri:Area/PascalFrancis/Corpus">000190</idno><idno type="wicri:Area/PascalFrancis/Curation">000798</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado</title><author><name sortKey="Dominguez, Samuel R" sort="Dominguez, Samuel R" uniqKey="Dominguez S" first="Samuel R." last="Dominguez">Samuel R. 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Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, University of Colorado Denver School of Medicine</s1><s2>Aurora, Colorado</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Journal of medical virology</title><title level="j" type="abbreviated">J. med. virol.</title><idno type="ISSN">0146-6615</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of medical virology</title><title level="j" type="abbreviated">J. med. virol.</title><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Colorado</term><term>Coronavirus</term><term>Detection</term><term>Respiratory disease</term><term>Rhinovirus</term><term>Viral disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Rhinovirus</term><term>Détection</term><term>Pathologie de l'appareil respiratoire</term><term>Enfant</term><term>Colorado</term><term>Virose</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. 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Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. 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