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Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado

Identifieur interne : 000190 ( PascalFrancis/Corpus ); précédent : 000189; suivant : 000191

Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado

Auteurs : Samuel R. Dominguez ; Christine C. Robinson ; Kathryn V. Holmes

Source :

RBID : Pascal:09-0379754

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English descriptors

Abstract

Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol.

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Pour connaître la documentation sur le format Inist Standard.

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A11 01  1    @1 DOMINGUEZ (Samuel R.)
A11 02  1    @1 ROBINSON (Christine C.)
A11 03  1    @1 HOLMES (Kathryn V.)
A14 01      @1 Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine @2 Aurora, Colorado @3 USA @Z 1 aut.
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Format Inist (serveur)

NO : PASCAL 09-0379754 INIST
ET : Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado
AU : DOMINGUEZ (Samuel R.); ROBINSON (Christine C.); HOLMES (Kathryn V.)
AF : Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (1 aut.); Department of Pathology and Laboratory Medicine, The Children's Hospital, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (2 aut.); Department of Microbiology, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (3 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of medical virology; ISSN 0146-6615; Coden JMVIDB; Etats-Unis; Da. 2009; Vol. 81; No. 9; Pp. 1597-1604; Bibl. 1 p.1/4
LA : Anglais
EA : Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol.
CC : 002B05C02C
FD : Coronavirus; Rhinovirus; Détection; Pathologie de l'appareil respiratoire; Enfant; Colorado; Virose
FG : Coronaviridae; Nidovirales; Virus; Picornaviridae; Homme; Etats-Unis; Amérique du Nord; Amérique; Infection
ED : Coronavirus; Rhinovirus; Detection; Respiratory disease; Child; Colorado; Viral disease
EG : Coronaviridae; Nidovirales; Virus; Picornaviridae; Human; United States; North America; America; Infection
SD : Coronavirus; Rhinovirus; Detección; Aparato respiratorio patología; Niño; Colorado; Virosis
LO : INIST-17422.354000172524700130
ID : 09-0379754

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Pascal:09-0379754

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<s0>Coronaviridae</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s0>Nidovirales</s0>
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<s2>NW</s2>
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<s0>Homme</s0>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Human</s0>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Hombre</s0>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Etats-Unis</s0>
<s2>NG</s2>
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<s0>United States</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Estados Unidos</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Amérique du Nord</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>North America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>America del norte</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Amérique</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Infection</s0>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Infection</s0>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Infección</s0>
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<NO>PASCAL 09-0379754 INIST</NO>
<ET>Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado</ET>
<AU>DOMINGUEZ (Samuel R.); ROBINSON (Christine C.); HOLMES (Kathryn V.)</AU>
<AF>Department of Pediatrics, The Children's Hospital, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (1 aut.); Department of Pathology and Laboratory Medicine, The Children's Hospital, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (2 aut.); Department of Microbiology, University of Colorado Denver School of Medicine/Aurora, Colorado/Etats-Unis (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of medical virology; ISSN 0146-6615; Coden JMVIDB; Etats-Unis; Da. 2009; Vol. 81; No. 9; Pp. 1597-1604; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Lower respiratory tract infections are the leading cause of death in children worldwide. Studies on the epidemiology and clinical associations of the four human non-SARS human coronaviruses (HCoVs) using sensitive polymerase chain reaction (PCR) assays are needed to evaluate the clinical significance of HCoV infections worldwide. Pediatric respiratory specimens (1,683) submitted to a diagnostic virology laboratory over a 1-year period (December 2004-November 2005) that were negative for seven respiratory viruses by conventional methods were tested for RNA of four HCoVs using sensitive RT-PCR assays. Coronavirus RNAs were detected in 84 (5.0%) specimens: HCoV-NL63 in 37 specimens, HCoV-OC43 in 34, HCoV-229E in 11, and HCoVHKU1 in 2. The majority of HCoV infections occurred during winter months, and over 62% were in previously healthy children. Twenty-six (41%) coronavirus positive patients had evidence of a lower respiratory tract infection (LRTI), 17 (26%) presented with vomiting and/or diarrhea, and 5 (8%) presented with meningoencephalitis or seizures. Respiratory specimens from one immunocompromised patient were persistently positive for HCoV-229E RNA for 3 months. HCoV-NL63-positive patients were nearly twice as likely to be hospitalized (P=0.02) and to have a LRTI (P=0.04) than HCoV-OC43-positive patients. HCoVs are associated with a small, but significant number (at least 2.4% of total samples submitted), of both upper and lower respiratory tract illnesses in children in Colorado. Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases. J. Med. Virol.</EA>
<CC>002B05C02C</CC>
<FD>Coronavirus; Rhinovirus; Détection; Pathologie de l'appareil respiratoire; Enfant; Colorado; Virose</FD>
<FG>Coronaviridae; Nidovirales; Virus; Picornaviridae; Homme; Etats-Unis; Amérique du Nord; Amérique; Infection</FG>
<ED>Coronavirus; Rhinovirus; Detection; Respiratory disease; Child; Colorado; Viral disease</ED>
<EG>Coronaviridae; Nidovirales; Virus; Picornaviridae; Human; United States; North America; America; Infection</EG>
<SD>Coronavirus; Rhinovirus; Detección; Aparato respiratorio patología; Niño; Colorado; Virosis</SD>
<LO>INIST-17422.354000172524700130</LO>
<ID>09-0379754</ID>
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