Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Identifieur interne : 004081 ( Main/Exploration ); précédent : 004080; suivant : 004082Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Auteurs : Th Boraud [France] ; E. Bezard [France] ; D. Guehl [France] ; B. Bioulac [France] ; Ch Gross [France]Source :
- Brain Research [ 0006-8993 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Animal, Animals, Chemotherapy, Discharge pattern, Dopa, Dopamine Agents (toxicity), Experimental disease, Female, Globus Pallidus (cytology), Globus Pallidus (drug effects), Immunohistochemistry, Levodopa (pharmacology), MPTP Poisoning, MPTP-treated monkey, Macaca mulatta, Monkey, Neurons (drug effects), Neurotoxin, Pallidum, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (pathology), Parkinson disease, Parkinson's disease, Treatment, Unit recordings of the globus pallidus (GPe, GPi), l-DOPA.
- MESH :
- chemical , pharmacology : Levodopa.
- chemical , toxicity : Dopamine Agents.
- chemically induced : Parkinson Disease, Secondary.
- cytology : Globus Pallidus.
- drug effects : Globus Pallidus, Neurons.
- drug therapy : Parkinson Disease, Secondary.
- pathology : Parkinson Disease, Secondary.
- Animals, Female, Immunohistochemistry, MPTP Poisoning, Macaca mulatta.
Abstract
We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.
Url:
DOI: 10.1016/S0006-8993(97)01563-1
Affiliations:
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<term>Discharge pattern</term>
<term>Dopa</term>
<term>Dopamine Agents (toxicity)</term>
<term>Experimental disease</term>
<term>Female</term>
<term>Globus Pallidus (cytology)</term>
<term>Globus Pallidus (drug effects)</term>
<term>Immunohistochemistry</term>
<term>Levodopa (pharmacology)</term>
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<term>Parkinson Disease, Secondary (drug therapy)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Treatment</term>
<term>Unit recordings of the globus pallidus (GPe, GPi)</term>
<term>l-DOPA</term>
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<front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div>
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