Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Identifieur interne : 001617 ( PascalFrancis/Corpus ); précédent : 001616; suivant : 001618Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Auteurs : T. Boraud ; E. Bezard ; D. Guehl ; B. Bioulac ; C. GrossSource :
- Brain research [ 0006-8993 ] ; 1998.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 98-0235202 INIST |
---|---|
ET : | Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey |
AU : | BORAUD (T.); BEZARD (E.); GUEHL (D.); BIOULAC (B.); GROSS (C.) |
AF : | Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat/33076 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1998; Vol. 787; No. 1; Pp. 157-160; Bibl. 20 ref. |
LA : | Anglais |
EA : | We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited. |
CC : | 002B17G |
FD : | Dopa; Pallidum; Neurotoxine; Mode décharge; Traitement; Parkinson maladie; Chimiothérapie; Pathologie expérimentale; Animal; Singe; MPTP |
FG : | Antiparkinsonien; Noyau gris central; Encéphale; Système nerveux central; Electrophysiologie; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Primates; Mammalia; Vertebrata |
ED : | Dopa; Pallidum; Neurotoxin; Discharge pattern; Treatment; Parkinson disease; Chemotherapy; Experimental disease; Animal; Monkey |
EG : | Antiparkinson agent; Basal ganglion; Brain (vertebrata); Central nervous system; Electrophysiology; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Primates; Mammalia; Vertebrata |
GD : | Aufbereiten |
SD : | Dopa; Pallidum; Neurotoxina; Forma descarga; Tratamiento; Parkinson enfermedad; Quimioterapia; Patología experimental; Animal; Mono |
LO : | INIST-12895.354000075495210210 |
ID : | 98-0235202 |
Links to Exploration step
Pascal:98-0235202Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E." last="Bezard">E. Bezard</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">98-0235202</idno>
<date when="1998">1998</date>
<idno type="stanalyst">PASCAL 98-0235202 INIST</idno>
<idno type="RBID">Pascal:98-0235202</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001617</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E." last="Bezard">E. Bezard</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Chemotherapy</term>
<term>Discharge pattern</term>
<term>Dopa</term>
<term>Experimental disease</term>
<term>Monkey</term>
<term>Neurotoxin</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dopa</term>
<term>Pallidum</term>
<term>Neurotoxine</term>
<term>Mode décharge</term>
<term>Traitement</term>
<term>Parkinson maladie</term>
<term>Chimiothérapie</term>
<term>Pathologie expérimentale</term>
<term>Animal</term>
<term>Singe</term>
<term>MPTP</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-8993</s0>
</fA01>
<fA02 i1="01"><s0>BRREAP</s0>
</fA02>
<fA03 i2="1"><s0>Brain res.</s0>
</fA03>
<fA05><s2>787</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BORAUD (T.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BEZARD (E.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GUEHL (D.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BIOULAC (B.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>GROSS (C.)</s1>
</fA11>
<fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>157-160</s1>
</fA20>
<fA21><s1>1998</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>12895</s2>
<s5>354000075495210210</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 1998 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>20 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>98-0235202</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i2="1"><s0>Brain research</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pallidum</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Pallidum</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Pallidum</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Neurotoxine</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Neurotoxin</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Neurotoxina</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Mode décharge</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Discharge pattern</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Forma descarga</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Treatment</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="GER"><s0>Aufbereiten</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Pathologie expérimentale</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Experimental disease</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Patología experimental</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Animal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Singe</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Monkey</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Mono</s0>
<s5>54</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>MPTP</s0>
<s4>INC</s4>
<s5>81</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Antiparkinsonien</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Antiparkinson agent</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Antiparkinsoniano</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>23</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>23</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>23</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>24</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>24</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>24</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>25</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Electrophysiologie</s0>
<s5>29</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Electrophysiology</s0>
<s5>29</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>29</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>153</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 98-0235202 INIST</NO>
<ET>Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</ET>
<AU>BORAUD (T.); BEZARD (E.); GUEHL (D.); BIOULAC (B.); GROSS (C.)</AU>
<AF>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat/33076 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1998; Vol. 787; No. 1; Pp. 157-160; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</EA>
<CC>002B17G</CC>
<FD>Dopa; Pallidum; Neurotoxine; Mode décharge; Traitement; Parkinson maladie; Chimiothérapie; Pathologie expérimentale; Animal; Singe; MPTP</FD>
<FG>Antiparkinsonien; Noyau gris central; Encéphale; Système nerveux central; Electrophysiologie; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Primates; Mammalia; Vertebrata</FG>
<ED>Dopa; Pallidum; Neurotoxin; Discharge pattern; Treatment; Parkinson disease; Chemotherapy; Experimental disease; Animal; Monkey</ED>
<EG>Antiparkinson agent; Basal ganglion; Brain (vertebrata); Central nervous system; Electrophysiology; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Primates; Mammalia; Vertebrata</EG>
<GD>Aufbereiten</GD>
<SD>Dopa; Pallidum; Neurotoxina; Forma descarga; Tratamiento; Parkinson enfermedad; Quimioterapia; Patología experimental; Animal; Mono</SD>
<LO>INIST-12895.354000075495210210</LO>
<ID>98-0235202</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001617 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001617 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:98-0235202 |texte= Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |