ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001617

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Identifieur interne : 001617 ( PascalFrancis/Corpus ); précédent : 001616; suivant : 001618

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Auteurs : T. Boraud ; E. Bezard ; D. Guehl ; B. Bioulac ; C. Gross

Source :

Brain research [ 0006-8993 ] ; 1998.

RBID : Pascal:98-0235202

Descripteurs français

Pascal (Inist)
- Dopa, Pallidum, Neurotoxine, Mode décharge, Traitement, Parkinson maladie, Chimiothérapie, Pathologie expérimentale, Animal, Singe, MPTP.

English descriptors

KwdEn :
- Animal, Chemotherapy, Discharge pattern, Dopa, Experimental disease, Monkey, Neurotoxin, Pallidum, Parkinson disease, Treatment.

Abstract

We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 BRREAP`
A03		`1`		`@0 Brain res.`
A05				`@2 787`
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A08	`01`	`1`	`ENG`	`@1 Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey`
A11	`01`	`1`		`@1 BORAUD (T.)`
A11	`02`	`1`		`@1 BEZARD (E.)`
A11	`03`	`1`		`@1 GUEHL (D.)`
A11	`04`	`1`		`@1 BIOULAC (B.)`
A11	`05`	`1`		`@1 GROSS (C.)`
A14	`01`			`@1 Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat @2 33076 Bordeaux @3 FRA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
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A21				`@1 1998`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 12895 @5 354000075495210210`
A44				`@0 0000 @1 © 1998 INIST-CNRS. All rights reserved.`
A45				`@0 20 ref.`
A47	`01`	`1`		`@0 98-0235202`
A60				`@1 P @3 CC`
A61				`@0 A`
A64		`1`		`@0 Brain research`
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C01	`01`		`ENG`	@0 We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Dopa @2 NK @2 FR @5 01`
C03	`01`	`X`	`ENG`	`@0 Dopa @2 NK @2 FR @5 01`
C03	`01`	`X`	`SPA`	`@0 Dopa @2 NK @2 FR @5 01`
C03	`02`	`X`	`FRE`	`@0 Pallidum @5 02`
C03	`02`	`X`	`ENG`	`@0 Pallidum @5 02`
C03	`02`	`X`	`SPA`	`@0 Pallidum @5 02`
C03	`03`	`X`	`FRE`	`@0 Neurotoxine @5 03`
C03	`03`	`X`	`ENG`	`@0 Neurotoxin @5 03`
C03	`03`	`X`	`SPA`	`@0 Neurotoxina @5 03`
C03	`04`	`X`	`FRE`	`@0 Mode décharge @5 04`
C03	`04`	`X`	`ENG`	`@0 Discharge pattern @5 04`
C03	`04`	`X`	`SPA`	`@0 Forma descarga @5 04`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 08`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 08`
C03	`05`	`X`	`GER`	`@0 Aufbereiten @5 08`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 08`
C03	`06`	`X`	`FRE`	`@0 Parkinson maladie @5 09`
C03	`06`	`X`	`ENG`	`@0 Parkinson disease @5 09`
C03	`06`	`X`	`SPA`	`@0 Parkinson enfermedad @5 09`
C03	`07`	`X`	`FRE`	`@0 Chimiothérapie @5 10`
C03	`07`	`X`	`ENG`	`@0 Chemotherapy @5 10`
C03	`07`	`X`	`SPA`	`@0 Quimioterapia @5 10`
C03	`08`	`X`	`FRE`	`@0 Pathologie expérimentale @5 11`
C03	`08`	`X`	`ENG`	`@0 Experimental disease @5 11`
C03	`08`	`X`	`SPA`	`@0 Patología experimental @5 11`
C03	`09`	`X`	`FRE`	`@0 Animal @5 13`
C03	`09`	`X`	`ENG`	`@0 Animal @5 13`
C03	`09`	`X`	`SPA`	`@0 Animal @5 13`
C03	`10`	`X`	`FRE`	`@0 Singe @5 54`
C03	`10`	`X`	`ENG`	`@0 Monkey @5 54`
C03	`10`	`X`	`SPA`	`@0 Mono @5 54`
C03	`11`	`X`	`FRE`	`@0 MPTP @4 INC @5 81`
C07	`01`	`X`	`FRE`	`@0 Antiparkinsonien @5 20`
C07	`01`	`X`	`ENG`	`@0 Antiparkinson agent @5 20`
C07	`01`	`X`	`SPA`	`@0 Antiparkinsoniano @5 20`
C07	`02`	`X`	`FRE`	`@0 Noyau gris central @5 23`
C07	`02`	`X`	`ENG`	`@0 Basal ganglion @5 23`
C07	`02`	`X`	`SPA`	`@0 Núcleo basal @5 23`
C07	`03`	`X`	`FRE`	`@0 Encéphale @5 24`
C07	`03`	`X`	`ENG`	`@0 Brain (vertebrata) @5 24`
C07	`03`	`X`	`SPA`	`@0 Encéfalo @5 24`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central @5 25`
C07	`04`	`X`	`ENG`	`@0 Central nervous system @5 25`
C07	`04`	`X`	`SPA`	`@0 Sistema nervioso central @5 25`
C07	`05`	`X`	`FRE`	`@0 Electrophysiologie @5 29`
C07	`05`	`X`	`ENG`	`@0 Electrophysiology @5 29`
C07	`05`	`X`	`SPA`	`@0 Electrofisiología @5 29`
C07	`06`	`X`	`FRE`	`@0 Système nerveux pathologie @5 38`
C07	`06`	`X`	`ENG`	`@0 Nervous system diseases @5 38`
C07	`06`	`X`	`SPA`	`@0 Sistema nervioso patología @5 38`
C07	`07`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 39`
C07	`07`	`X`	`ENG`	`@0 Central nervous system disease @5 39`
C07	`07`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 39`
C07	`08`	`X`	`FRE`	`@0 Encéphale pathologie @5 40`
C07	`08`	`X`	`ENG`	`@0 Cerebral disorder @5 40`
C07	`08`	`X`	`SPA`	`@0 Encéfalo patología @5 40`
C07	`09`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 41`
C07	`09`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`09`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`10`	`X`	`FRE`	`@0 Maladie dégénérative @5 42`
C07	`10`	`X`	`ENG`	`@0 Degenerative disease @5 42`
C07	`10`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 42`
C07	`11`	`X`	`FRE`	`@0 Primates @2 NS`
C07	`11`	`X`	`ENG`	`@0 Primates @2 NS`
C07	`11`	`X`	`SPA`	`@0 Primates @2 NS`
C07	`12`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`12`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`12`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`13`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`13`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`13`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 153`

Format Inist (serveur)

NO :	PASCAL 98-0235202 INIST
ET :	Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
AU :	BORAUD (T.); BEZARD (E.); GUEHL (D.); BIOULAC (B.); GROSS (C.)
AF :	Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat/33076 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1998; Vol. 787; No. 1; Pp. 157-160; Bibl. 20 ref.
LA :	Anglais
EA :	We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.
CC :	002B17G
FD :	Dopa; Pallidum; Neurotoxine; Mode décharge; Traitement; Parkinson maladie; Chimiothérapie; Pathologie expérimentale; Animal; Singe; MPTP
FG :	Antiparkinsonien; Noyau gris central; Encéphale; Système nerveux central; Electrophysiologie; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Primates; Mammalia; Vertebrata
ED :	Dopa; Pallidum; Neurotoxin; Discharge pattern; Treatment; Parkinson disease; Chemotherapy; Experimental disease; Animal; Monkey
EG :	Antiparkinson agent; Basal ganglion; Brain (vertebrata); Central nervous system; Electrophysiology; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Primates; Mammalia; Vertebrata
GD :	Aufbereiten
SD :	Dopa; Pallidum; Neurotoxina; Forma descarga; Tratamiento; Parkinson enfermedad; Quimioterapia; Patología experimental; Animal; Mono
LO :	INIST-12895.354000075495210210
ID :	98-0235202

Links to Exploration step

Pascal:98-0235202

Le document en format XML

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<front><div type="abstract" xml:lang="en">We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</div>
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<fC01 i1="01" l="ENG"><s0>We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Dopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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<s5>03</s5>
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<s5>03</s5>
</fC03>
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<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
</fC03>
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<s5>04</s5>
</fC03>
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<s5>08</s5>
</fC03>
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</fC03>
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<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>54</s5>
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<s5>54</s5>
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<s5>54</s5>
</fC03>
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<s4>INC</s4>
<s5>81</s5>
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<s5>20</s5>
</fC07>
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<s5>20</s5>
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<s5>20</s5>
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<s5>23</s5>
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<s5>23</s5>
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<s5>23</s5>
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<s5>24</s5>
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<s5>24</s5>
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<s5>25</s5>
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<s5>25</s5>
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<s5>29</s5>
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<s5>29</s5>
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<s5>29</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>39</s5>
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<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>153</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 98-0235202 INIST</NO>
<ET>Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</ET>
<AU>BORAUD (T.); BEZARD (E.); GUEHL (D.); BIOULAC (B.); GROSS (C.)</AU>
<AF>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat/33076 Bordeaux/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1998; Vol. 787; No. 1; Pp. 157-160; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</EA>
<CC>002B17G</CC>
<FD>Dopa; Pallidum; Neurotoxine; Mode décharge; Traitement; Parkinson maladie; Chimiothérapie; Pathologie expérimentale; Animal; Singe; MPTP</FD>
<FG>Antiparkinsonien; Noyau gris central; Encéphale; Système nerveux central; Electrophysiologie; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Primates; Mammalia; Vertebrata</FG>
<ED>Dopa; Pallidum; Neurotoxin; Discharge pattern; Treatment; Parkinson disease; Chemotherapy; Experimental disease; Animal; Monkey</ED>
<EG>Antiparkinson agent; Basal ganglion; Brain (vertebrata); Central nervous system; Electrophysiology; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Primates; Mammalia; Vertebrata</EG>
<GD>Aufbereiten</GD>
<SD>Dopa; Pallidum; Neurotoxina; Forma descarga; Tratamiento; Parkinson enfermedad; Quimioterapia; Patología experimental; Animal; Mono</SD>
<LO>INIST-12895.354000075495210210</LO>
<ID>98-0235202</ID>
</server>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

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