Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Identifieur interne : 000533 ( Istex/Corpus ); précédent : 000532; suivant : 000534Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Auteurs : Th Boraud ; E. Bezard ; D. Guehl ; B. Bioulac ; Ch GrossSource :
- Brain Research [ 0006-8993 ] ; 1998.
English descriptors
- KwdEn :
Abstract
We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.
Url:
DOI: 10.1016/S0006-8993(97)01563-1
Links to Exploration step
ISTEX:3759171F6694F1802E7557E0225516F539CAF014Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title><author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3759171F6694F1802E7557E0225516F539CAF014</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0006-8993(97)01563-1</idno><idno type="url">https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000533</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000533</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title><author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name><affiliation><mods:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">787</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="160">160</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">3759171F6694F1802E7557E0225516F539CAF014</idno><idno type="DOI">10.1016/S0006-8993(97)01563-1</idno><idno type="PII">S0006-8993(97)01563-1</idno><idno type="ArticleID">27620</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MPTP-treated monkey</term><term>Parkinson's disease</term><term>Unit recordings of the globus pallidus (GPe, GPi)</term><term>l-DOPA</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Th Boraud</name><affiliations><json:string>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</json:string></affiliations></json:item><json:item><name>E Bezard</name><affiliations><json:string>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</json:string></affiliations></json:item><json:item><name>D Guehl</name><affiliations><json:string>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</json:string></affiliations></json:item><json:item><name>B Bioulac</name><affiliations><json:string>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</json:string></affiliations></json:item><json:item><name>Ch Gross</name><affiliations><json:string>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MPTP-treated monkey</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>l-DOPA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Unit recordings of the globus pallidus (GPe, GPi)</value></json:item></subject><articleId><json:string>27620</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</abstract><qualityIndicators><score>3.769</score><pdfVersion>1.2</pdfVersion><pdfPageSize>595 x 738 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>700</abstractCharCount><pdfWordCount>2449</pdfWordCount><pdfCharCount>14539</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>110</abstractWordCount></qualityIndicators><title>Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title><pii><json:string>S0006-8993(97)01563-1</json:string></pii><refBibs><json:item><author><json:item><name>R.L. Albin</name></json:item><json:item><name>A.B. Young</name></json:item><json:item><name>J.B. Penney</name></json:item></author><host><volume>12</volume><pages><last>375</last><first>366</first></pages><author></author><title>Trends Neurosci.</title></host><title>The functional anatomy of basal ganglia disorders</title></json:item><json:item><author><json:item><name>G.E. Alexander</name></json:item><json:item><name>M.D. Crutcher</name></json:item></author><host><volume>13</volume><pages><last>271</last><first>266</first></pages><author></author><title>Trends Neurosci.</title></host><title>Functional architecture of basal ganglia circuits: neural substrates of parallel processing</title></json:item><json:item><author><json:item><name>K.S. Bankiewicz</name></json:item><json:item><name>E.H. Oldfield</name></json:item><json:item><name>C.C. Chiueh</name></json:item><json:item><name>J.L. Doppman</name></json:item><json:item><name>D.M. Jacobowitz</name></json:item><json:item><name>I.J. Kopin</name></json:item></author><host><volume>39</volume><pages><last>16</last><first>7</first></pages><author></author><title>Life Sci.</title></host><title>Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of MPTP</title></json:item><json:item><author><json:item><name>A. Benazzouz</name></json:item><json:item><name>T. Boraud</name></json:item><json:item><name>P. Dubedat</name></json:item><json:item><name>A. Boireau</name></json:item><json:item><name>J.M. Stutzmann</name></json:item><json:item><name>C. Gross</name></json:item></author><host><volume>284</volume><pages><last>307</last><first>299</first></pages><author></author><title>Eur. J. Pharmacol.</title></host><title>Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a preliminary study</title></json:item><json:item><author><json:item><name>A. Benazzouz</name></json:item><json:item><name>C. Gross</name></json:item><json:item><name>J. Féger</name></json:item><json:item><name>T. Boraud</name></json:item><json:item><name>B. Bioulac</name></json:item></author><host><volume>5</volume><pages><last>389</last><first>382</first></pages><author></author><title>Eur. J. Neurosci.</title></host><title>Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys</title></json:item><json:item><author><json:item><name>E. Bezard</name></json:item><json:item><name>C. Imbert</name></json:item><json:item><name>X. Deloire</name></json:item><json:item><name>B. Bioulac</name></json:item><json:item><name>C. Gross</name></json:item></author><host><volume>766</volume><pages><last>112</last><first>107</first></pages><author></author><title>Brain Res.</title></host><title>A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey</title></json:item><json:item><author><json:item><name>W. Birkmayer</name></json:item><json:item><name>O. Hornykiewicz</name></json:item></author><host><volume>203</volume><pages><last>574</last><first>560</first></pages><author></author><title>Arch. Psychiat. Nervenkr.</title></host><title>Der l-DOPA effekt beim Parkinson-Syndrom des Menschen. Zur Pathogenese und Behandlung der Parkinson-Akinese</title></json:item><json:item><author><json:item><name>T. Boraud</name></json:item><json:item><name>E. Bezard</name></json:item><json:item><name>B. Bioulac</name></json:item><json:item><name>C. Gross</name></json:item></author><host><volume>215</volume><pages><last>20</last><first>17</first></pages><author></author><title>Neurosci. Lett.</title></host><title>High-frequency stimulation of the internal globus pallidus reduces the higher firing frequency of its neurons in the MPTP-treated monkey model of Parkinson's disease</title></json:item><json:item><author><json:item><name>M. Filion</name></json:item><json:item><name>L. Tremblay</name></json:item></author><host><volume>547</volume><pages><last>151</last><first>142</first></pages><author></author><title>Brain Res.</title></host><title>Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism</title></json:item><json:item><author><json:item><name>M. Filion</name></json:item><json:item><name>L. Tremblay</name></json:item><json:item><name>P.J. Bedard</name></json:item></author><host><volume>547</volume><pages><last>161</last><first>152</first></pages><author></author><title>Brain Res.</title></host><title>Effects of dopamine agonists on the spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism</title></json:item><json:item><author><json:item><name>A.M. Graybiel</name></json:item><json:item><name>T. Aosaki</name></json:item><json:item><name>A.W. Flaherty</name></json:item><json:item><name>M. Kimura</name></json:item></author><host><volume>265</volume><pages><last>1831</last><first>1826</first></pages><author></author><title>Science</title></host><title>The basal ganglia and adaptive motor control</title></json:item><json:item><author><json:item><name>O.K. Hassani</name></json:item><json:item><name>C. François</name></json:item><json:item><name>J. Yelnik</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>749</volume><pages><last>94</last><first>88</first></pages><author></author><title>Brain Res.</title></host><title>Evidence for a dopaminergic innervation of the subthalamic nucleus in the rat</title></json:item><json:item><author><json:item><name>M.T. Herrero</name></json:item><json:item><name>R. Levy</name></json:item><json:item><name>M. Ruberg</name></json:item><json:item><name>M.R. Luquin</name></json:item><json:item><name>J. Villares</name></json:item><json:item><name>J. Guillen</name></json:item><json:item><name>B. Faucheux</name></json:item><json:item><name>F. Javoy-Agid</name></json:item><json:item><name>J. Guridi</name></json:item><json:item><name>Y. Agid</name></json:item><json:item><name>J.A. Obeso</name></json:item><json:item><name>E.C. Hirsch</name></json:item></author><host><volume>47</volume><pages><last>224</last><first>219</first></pages><author></author><title>Neurology</title></host><title>Consequence of nigrostriatal denervation and l-DOPA therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum</title></json:item><json:item><host><author></author></host></json:item><json:item><author><json:item><name>Y. Kaneoke</name></json:item><json:item><name>J.L. Vitek</name></json:item></author><host><volume>68</volume><pages><last>223</last><first>211</first></pages><author></author><title>J. Neurosci. Methods</title></host><title>Burst and oscillations as disparate neuronal properties</title></json:item><json:item><author><json:item><name>J.W. Langston</name></json:item><json:item><name>H. Widner</name></json:item><json:item><name>C.G. Goetz</name></json:item><json:item><name>D. Brooks</name></json:item><json:item><name>S. Fahn</name></json:item><json:item><name>T. Freeman</name></json:item><json:item><name>R. Watts</name></json:item></author><host><volume>7</volume><pages><last>13</last><first>2</first></pages><author></author><title>Mov. Disord.</title></host><title>Core assessment program for intracerebral transplantations (CAPIT)</title></json:item><json:item><author><json:item><name>A.J. Lees</name></json:item></author><host><volume>17</volume><pages><last>6</last><first>1</first></pages><author></author><title>Clin. Neuropharmacol.</title></host><title>Levodopa substitution: the gold standard</title></json:item><json:item><author><json:item><name>R. Levy</name></json:item><json:item><name>L.-N. Hazrati</name></json:item><json:item><name>M.-T. Herrero</name></json:item><json:item><name>M. Vila</name></json:item><json:item><name>O.-K. Hassani</name></json:item><json:item><name>M. Mouroux</name></json:item><json:item><name>M. Ruberg</name></json:item><json:item><name>H. Asensi</name></json:item><json:item><name>Y. Agid</name></json:item><json:item><name>J. Féger</name></json:item><json:item><name>J.A. Obeso</name></json:item><json:item><name>A. Parent</name></json:item><json:item><name>E.C. Hirsch</name></json:item></author><host><volume>76</volume><pages><last>343</last><first>335</first></pages><author></author><title>Neuroscience</title></host><title>Re-evaluation of the functional anatomy of the basal ganglia in normal and parkinsonian states</title></json:item><json:item><author><json:item><name>M. Vila</name></json:item><json:item><name>R. Levy</name></json:item><json:item><name>M.-T. Herrero</name></json:item><json:item><name>M. Ruberg</name></json:item><json:item><name>B. Faucheux</name></json:item><json:item><name>J.A. Obeso</name></json:item><json:item><name>Y. Agid</name></json:item><json:item><name>E.C. Hirsch</name></json:item></author><host><volume>17</volume><pages><last>773</last><first>765</first></pages><author></author><title>J. Neurosci.</title></host><title>Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA</title></json:item><json:item><author><json:item><name>M.D. Yahr</name></json:item><json:item><name>R.C. Duvoisin</name></json:item><json:item><name>M.M. Hoehn</name></json:item><json:item><name>M.J. Schear</name></json:item><json:item><name>R.E. Barrett</name></json:item></author><host><volume>93</volume><pages><last>63</last><first>56</first></pages><author></author><title>Trans. Am. Neurol. Ass.</title></host><title>l-DOPA: its clinical effects in parkinsonism</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>787</volume><pii><json:string>S0006-8993(00)X0151-5</json:string></pii><pages><last>160</last><first>157</first></pages><issn><json:string>0006-8993</json:string></issn><issue>1</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Brain Research</title><publicationDate>1998</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1016/S0006-8993(97)01563-1</json:string></doi><id>3759171F6694F1802E7557E0225516F539CAF014</id><score>0.17196295</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1998 Elsevier Science B.V.</p></availability><date>1998</date></publicationStmt><notesStmt><note type="content">Section title: Short communication</note><note type="content">Fig. 1: Characteristic examples of the three patterns of neuronal activity in the pallidal complex. (A) An irregular neuron (recorded in the GPi of a normal animal). (B) A regular neuron (recorded in the GPi of a normal animal). (C) A bursting neuron (recorded in the GPe in an MPTP-treated animal after administration of l-DOPA). Each recording is presented as follows: Left: Density histogram (DH) representing the number of spikes in an interval of t=1/F (F=mean firing frequency); ordinate: frequency of intervals; abscissa: density of discharge (spikes). The number of intervals without any spike is plotted in the left bin, the number with one spike in the next bin, with two in the following, and so on from left to right. A comparison is made with a Poisson distribution with a mean of 1.0, calculated using the χ2 test (χ2; p<0.05) and represented by the line on the histogram. FD: degree of freedom. Right: (top): raster display (time base: 125 ms), (bottom): time interval histogram (TIH, bin width: 1 ms).</note><note type="content">Fig. 2: Electrophysiological activity of the GPe (A, B). (A) Mean firing frequency [F: spikes/s (Hz)±S.D.] of neurons in the three experimental situations (n=number of neurons). White column: normal situation, black column: after MPTP injection, shaded column: after MPTP injection and following l-DOPA treatment. (B) Graphic presentation of percentage distribution of the different patterns of discharge (irregular, regular, bursting) in the three experimental situations. Electrophysiological activity of the GPi (C, D). (C) As for A. (D) As for B. *significance as compared to normal (Student's t-test), Δ significance as compared to MPTP (Student's t-test). (E) Continuous recording of a GPi neuron in an MPTP-treated monkey from before the oral administration of l-DOPA until the beginning of the `best on' period. (Top) position on a schematic frontal plane (A: 11.5, H: depth, L: laterality) of the electrode track in the GPi. The black dot corresponds to the recording site of the neuron (LD 21) presented below. (Bottom) raster display before and after the administration (arrow) of l-DOPA. Thirty minutes after drug intake (horizontal broken line), a decrease in firing activity is visible on the raster display.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title><author xml:id="author-1"><persName><forename type="first">Th</forename><surname>Boraud</surname></persName><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">E</forename><surname>Bezard</surname></persName><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">D</forename><surname>Guehl</surname></persName><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">B</forename><surname>Bioulac</surname></persName><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Ch</forename><surname>Gross</surname></persName><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X0151-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">787</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="160">160</biblScope></imprint></monogr><idno type="istex">3759171F6694F1802E7557E0225516F539CAF014</idno><idno type="DOI">10.1016/S0006-8993(97)01563-1</idno><idno type="PII">S0006-8993(97)01563-1</idno><idno type="ArticleID">27620</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>MPTP-treated monkey</term></item><item><term>l-DOPA</term></item><item><term>Unit recordings of the globus pallidus (GPe, GPi)</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>BRES</jid><aid>27620</aid><ce:pii>S0006-8993(97)01563-1</ce:pii><ce:doi>10.1016/S0006-8993(97)01563-1</ce:doi><ce:copyright year="1998" type="full-transfer">Elsevier Science B.V.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>Effects of <ce:small-caps>l</ce:small-caps>-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</ce:title><ce:author-group><ce:author><ce:given-name>Th</ce:given-name><ce:surname>Boraud</ce:surname><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>E</ce:given-name><ce:surname>Bezard</ce:surname></ce:author><ce:author><ce:given-name>D</ce:given-name><ce:surname>Guehl</ce:surname></ce:author><ce:author><ce:given-name>B</ce:given-name><ce:surname>Bioulac</ce:surname></ce:author><ce:author><ce:given-name>Ch</ce:given-name><ce:surname>Gross</ce:surname></ce:author><ce:affiliation><ce:textfn>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Fax: +33-556-90-14-21; E-mail: thomas.boraud@umr5543.u-bordeaux2.fr</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="16" month="12" year="1997"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0020">We studied the effects of <ce:small-caps>l</ce:small-caps>-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During <ce:small-caps>l</ce:small-caps>-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of <ce:small-caps>l</ce:small-caps>-DOPA on GPi output is limited.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>MPTP-treated monkey</ce:text></ce:keyword><ce:keyword><ce:text><ce:small-caps>l</ce:small-caps>-DOPA</ce:text></ce:keyword><ce:keyword><ce:text>Unit recordings of the globus pallidus (GPe, GPi)</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Effects of</title></titleInfo><name type="personal"><namePart type="given">Th</namePart><namePart type="family">Boraud</namePart><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation><description>Corresponding author. Fax: +33-556-90-14-21; E-mail: thomas.boraud@umr5543.u-bordeaux2.fr</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Bezard</namePart><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Guehl</namePart><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Bioulac</namePart><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ch</namePart><namePart type="family">Gross</namePart><affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</abstract><note type="content">Section title: Short communication</note><note type="content">Fig. 1: Characteristic examples of the three patterns of neuronal activity in the pallidal complex. (A) An irregular neuron (recorded in the GPi of a normal animal). (B) A regular neuron (recorded in the GPi of a normal animal). (C) A bursting neuron (recorded in the GPe in an MPTP-treated animal after administration of l-DOPA). Each recording is presented as follows: Left: Density histogram (DH) representing the number of spikes in an interval of t=1/F (F=mean firing frequency); ordinate: frequency of intervals; abscissa: density of discharge (spikes). The number of intervals without any spike is plotted in the left bin, the number with one spike in the next bin, with two in the following, and so on from left to right. A comparison is made with a Poisson distribution with a mean of 1.0, calculated using the χ2 test (χ2; p<0.05) and represented by the line on the histogram. FD: degree of freedom. Right: (top): raster display (time base: 125 ms), (bottom): time interval histogram (TIH, bin width: 1 ms).</note><note type="content">Fig. 2: Electrophysiological activity of the GPe (A, B). (A) Mean firing frequency [F: spikes/s (Hz)±S.D.] of neurons in the three experimental situations (n=number of neurons). White column: normal situation, black column: after MPTP injection, shaded column: after MPTP injection and following l-DOPA treatment. (B) Graphic presentation of percentage distribution of the different patterns of discharge (irregular, regular, bursting) in the three experimental situations. Electrophysiological activity of the GPi (C, D). (C) As for A. (D) As for B. *significance as compared to normal (Student's t-test), Δ significance as compared to MPTP (Student's t-test). (E) Continuous recording of a GPi neuron in an MPTP-treated monkey from before the oral administration of l-DOPA until the beginning of the `best on' period. (Top) position on a schematic frontal plane (A: 11.5, H: depth, L: laterality) of the electrode track in the GPi. The black dot corresponds to the recording site of the neuron (LD 21) presented below. (Bottom) raster display before and after the administration (arrow) of l-DOPA. Thirty minutes after drug intake (horizontal broken line), a decrease in firing activity is visible on the raster display.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>MPTP-treated monkey</topic><topic>l-DOPA</topic><topic>Unit recordings of the globus pallidus (GPe, GPi)</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19980316</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X0151-5</identifier><part><date>19980316</date><detail type="volume"><number>787</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>180</end></extent><extent unit="pages"><start>157</start><end>160</end></extent></part></relatedItem><identifier type="istex">3759171F6694F1802E7557E0225516F539CAF014</identifier><identifier type="DOI">10.1016/S0006-8993(97)01563-1</identifier><identifier type="PII">S0006-8993(97)01563-1</identifier><identifier type="ArticleID">27620</identifier><accessCondition type="use and reproduction" contentType="copyright">©1998 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©1998</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000533 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000533 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:3759171F6694F1802E7557E0225516F539CAF014
|texte= Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
}}
| This area was generated with Dilib version V0.6.29. |  |