Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Identifieur interne : 000533 ( Istex/Corpus ); précédent : 000532; suivant : 000534Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Auteurs : Th Boraud ; E. Bezard ; D. Guehl ; B. Bioulac ; Ch GrossSource :
- Brain Research [ 0006-8993 ] ; 1998.
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Abstract
We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.
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DOI: 10.1016/S0006-8993(97)01563-1
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<front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div>
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<abstract>We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</abstract>
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<note type="content">Fig. 1: Characteristic examples of the three patterns of neuronal activity in the pallidal complex. (A) An irregular neuron (recorded in the GPi of a normal animal). (B) A regular neuron (recorded in the GPi of a normal animal). (C) A bursting neuron (recorded in the GPe in an MPTP-treated animal after administration of l-DOPA). Each recording is presented as follows: Left: Density histogram (DH) representing the number of spikes in an interval of t=1/F (F=mean firing frequency); ordinate: frequency of intervals; abscissa: density of discharge (spikes). The number of intervals without any spike is plotted in the left bin, the number with one spike in the next bin, with two in the following, and so on from left to right. A comparison is made with a Poisson distribution with a mean of 1.0, calculated using the χ2 test (χ2; p<0.05) and represented by the line on the histogram. FD: degree of freedom. Right: (top): raster display (time base: 125 ms), (bottom): time interval histogram (TIH, bin width: 1 ms).</note>
<note type="content">Fig. 2: Electrophysiological activity of the GPe (A, B). (A) Mean firing frequency [F: spikes/s (Hz)±S.D.] of neurons in the three experimental situations (n=number of neurons). White column: normal situation, black column: after MPTP injection, shaded column: after MPTP injection and following l-DOPA treatment. (B) Graphic presentation of percentage distribution of the different patterns of discharge (irregular, regular, bursting) in the three experimental situations. Electrophysiological activity of the GPi (C, D). (C) As for A. (D) As for B. *significance as compared to normal (Student's t-test), Δ significance as compared to MPTP (Student's t-test). (E) Continuous recording of a GPi neuron in an MPTP-treated monkey from before the oral administration of l-DOPA until the beginning of the `best on' period. (Top) position on a schematic frontal plane (A: 11.5, H: depth, L: laterality) of the electrode track in the GPi. The black dot corresponds to the recording site of the neuron (LD 21) presented below. (Bottom) raster display before and after the administration (arrow) of l-DOPA. Thirty minutes after drug intake (horizontal broken line), a decrease in firing activity is visible on the raster display.</note>
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<abstract lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</abstract>
<note type="content">Section title: Short communication</note>
<note type="content">Fig. 1: Characteristic examples of the three patterns of neuronal activity in the pallidal complex. (A) An irregular neuron (recorded in the GPi of a normal animal). (B) A regular neuron (recorded in the GPi of a normal animal). (C) A bursting neuron (recorded in the GPe in an MPTP-treated animal after administration of l-DOPA). Each recording is presented as follows: Left: Density histogram (DH) representing the number of spikes in an interval of t=1/F (F=mean firing frequency); ordinate: frequency of intervals; abscissa: density of discharge (spikes). The number of intervals without any spike is plotted in the left bin, the number with one spike in the next bin, with two in the following, and so on from left to right. A comparison is made with a Poisson distribution with a mean of 1.0, calculated using the χ2 test (χ2; p<0.05) and represented by the line on the histogram. FD: degree of freedom. Right: (top): raster display (time base: 125 ms), (bottom): time interval histogram (TIH, bin width: 1 ms).</note>
<note type="content">Fig. 2: Electrophysiological activity of the GPe (A, B). (A) Mean firing frequency [F: spikes/s (Hz)±S.D.] of neurons in the three experimental situations (n=number of neurons). White column: normal situation, black column: after MPTP injection, shaded column: after MPTP injection and following l-DOPA treatment. (B) Graphic presentation of percentage distribution of the different patterns of discharge (irregular, regular, bursting) in the three experimental situations. Electrophysiological activity of the GPi (C, D). (C) As for A. (D) As for B. *significance as compared to normal (Student's t-test), Δ significance as compared to MPTP (Student's t-test). (E) Continuous recording of a GPi neuron in an MPTP-treated monkey from before the oral administration of l-DOPA until the beginning of the `best on' period. (Top) position on a schematic frontal plane (A: 11.5, H: depth, L: laterality) of the electrode track in the GPi. The black dot corresponds to the recording site of the neuron (LD 21) presented below. (Bottom) raster display before and after the administration (arrow) of l-DOPA. Thirty minutes after drug intake (horizontal broken line), a decrease in firing activity is visible on the raster display.</note>
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