ParkinsonFranceV1, Main, Curation, bibRecord, 004081

Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Identifieur interne : 004081 ( Main/Curation ); précédent : 004080; suivant : 004082

Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Auteurs : Th Boraud [France] ; E. Bezard [France] ; D. Guehl [France] ; B. Bioulac [France] ; Ch Gross [France]

Source :

Brain Research [ 0006-8993 ] ; 1998.

RBID : ISTEX:3759171F6694F1802E7557E0225516F539CAF014

Descripteurs français

Pascal (Inist)
- Animal, Chimiothérapie, Dopa, MPTP, Mode décharge, Neurotoxine, Pallidum, Parkinson maladie, Pathologie expérimentale, Singe, Traitement.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Animal, Animals, Chemotherapy, Discharge pattern, Dopa, Dopamine Agents (toxicity), Experimental disease, Female, Globus Pallidus (cytology), Globus Pallidus (drug effects), Immunohistochemistry, Levodopa (pharmacology), MPTP Poisoning, MPTP-treated monkey, Macaca mulatta, Monkey, Neurons (drug effects), Neurotoxin, Pallidum, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (pathology), Parkinson disease, Parkinson's disease, Treatment, Unit recordings of the globus pallidus (GPe, GPi), l-DOPA.
MESH :
- chemical , pharmacology : Levodopa.
- chemical , toxicity : Dopamine Agents.
- chemically induced : Parkinson Disease, Secondary.
- cytology : Globus Pallidus.
- drug effects : Globus Pallidus, Neurons.
- drug therapy : Parkinson Disease, Secondary.
- pathology : Parkinson Disease, Secondary.
- Animals, Female, Immunohistochemistry, MPTP Poisoning, Macaca mulatta.

Abstract

We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.

Url:

https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/pdf

DOI: 10.1016/S0006-8993(97)01563-1

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000533
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000533
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001503
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004861
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001617
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001A29
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001452
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004956
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001477
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001436
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001436
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001F10
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F10
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F10
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004728

Links to Exploration step

ISTEX:3759171F6694F1802E7557E0225516F539CAF014

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3759171F6694F1802E7557E0225516F539CAF014</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1016/S0006-8993(97)01563-1</idno>
<idno type="url">https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000533</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000533</idno>
<idno type="wicri:Area/Istex/Curation">000533</idno>
<idno type="wicri:Area/Istex/Checkpoint">001503</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001503</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004861</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:98-0235202</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001617</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A29</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001452</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001452</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004956</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:9518590</idno>
<idno type="wicri:Area/PubMed/Corpus">001477</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001477</idno>
<idno type="wicri:Area/PubMed/Curation">001436</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001436</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001436</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001436</idno>
<idno type="wicri:Area/Ncbi/Merge">001F10</idno>
<idno type="wicri:Area/Ncbi/Curation">001F10</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F10</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004728</idno>
<idno type="wicri:Area/Main/Curation">004081</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain Research</title>
<title level="j" type="abbrev">BRES</title>
<idno type="ISSN">0006-8993</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1998">1998</date>
<biblScope unit="volume">787</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="157">157</biblScope>
<biblScope unit="page" to="160">160</biblScope>
</imprint>
<idno type="ISSN">0006-8993</idno>
</series>
<idno type="istex">3759171F6694F1802E7557E0225516F539CAF014</idno>
<idno type="DOI">10.1016/S0006-8993(97)01563-1</idno>
<idno type="PII">S0006-8993(97)01563-1</idno>
<idno type="ArticleID">27620</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animals</term>
<term>Chemotherapy</term>
<term>Discharge pattern</term>
<term>Dopa</term>
<term>Dopamine Agents (toxicity)</term>
<term>Experimental disease</term>
<term>Female</term>
<term>Globus Pallidus (cytology)</term>
<term>Globus Pallidus (drug effects)</term>
<term>Immunohistochemistry</term>
<term>Levodopa (pharmacology)</term>
<term>MPTP Poisoning</term>
<term>MPTP-treated monkey</term>
<term>Macaca mulatta</term>
<term>Monkey</term>
<term>Neurons (drug effects)</term>
<term>Neurotoxin</term>
<term>Pallidum</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (drug therapy)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Treatment</term>
<term>Unit recordings of the globus pallidus (GPe, GPi)</term>
<term>l-DOPA</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Dopamine Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Globus Pallidus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Globus Pallidus</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Immunohistochemistry</term>
<term>MPTP Poisoning</term>
<term>Macaca mulatta</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal</term>
<term>Chimiothérapie</term>
<term>Dopa</term>
<term>MPTP</term>
<term>Mode décharge</term>
<term>Neurotoxine</term>
<term>Pallidum</term>
<term>Parkinson maladie</term>
<term>Pathologie expérimentale</term>
<term>Singe</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div>
</front>
</TEI>
<double idat="0006-8993:1998:Boraud T:effects:of:l"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E." last="Bezard">E. Bezard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">98-0235202</idno>
<date when="1998">1998</date>
<idno type="stanalyst">PASCAL 98-0235202 INIST</idno>
<idno type="RBID">Pascal:98-0235202</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001617</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A29</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001452</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001452</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004956</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E." last="Bezard">E. Bezard</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat</s1>
<s2>33076 Bordeaux</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Chemotherapy</term>
<term>Discharge pattern</term>
<term>Dopa</term>
<term>Experimental disease</term>
<term>Monkey</term>
<term>Neurotoxin</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Dopa</term>
<term>Pallidum</term>
<term>Neurotoxine</term>
<term>Mode décharge</term>
<term>Traitement</term>
<term>Parkinson maladie</term>
<term>Chimiothérapie</term>
<term>Pathologie expérimentale</term>
<term>Animal</term>
<term>Singe</term>
<term>MPTP</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3759171F6694F1802E7557E0225516F539CAF014</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1016/S0006-8993(97)01563-1</idno>
<idno type="url">https://api.istex.fr/document/3759171F6694F1802E7557E0225516F539CAF014/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000533</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000533</idno>
<idno type="wicri:Area/Istex/Curation">000533</idno>
<idno type="wicri:Area/Istex/Checkpoint">001503</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001503</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004861</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey</title>
<author><name sortKey="Boraud, Th" sort="Boraud, Th" uniqKey="Boraud T" first="Th" last="Boraud">Th Boraud</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gross, Ch" sort="Gross, Ch" uniqKey="Gross C" first="Ch" last="Gross">Ch Gross</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain Research</title>
<title level="j" type="abbrev">BRES</title>
<idno type="ISSN">0006-8993</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1998">1998</date>
<biblScope unit="volume">787</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="157">157</biblScope>
<biblScope unit="page" to="160">160</biblScope>
</imprint>
<idno type="ISSN">0006-8993</idno>
</series>
<idno type="istex">3759171F6694F1802E7557E0225516F539CAF014</idno>
<idno type="DOI">10.1016/S0006-8993(97)01563-1</idno>
<idno type="PII">S0006-8993(97)01563-1</idno>
<idno type="ArticleID">27620</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MPTP-treated monkey</term>
<term>Parkinson's disease</term>
<term>Unit recordings of the globus pallidus (GPe, GPi)</term>
<term>l-DOPA</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
<affiliation wicri:level="3"><nlm:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France. thomas.boraud@umr5543.u-bordeaux2.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1998">1998</date>
<idno type="RBID">pubmed:9518590</idno>
<idno type="pmid">9518590</idno>
<idno type="wicri:Area/PubMed/Corpus">001477</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001477</idno>
<idno type="wicri:Area/PubMed/Curation">001436</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001436</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001436</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001436</idno>
<idno type="wicri:Area/Ncbi/Merge">001F10</idno>
<idno type="wicri:Area/Ncbi/Curation">001F10</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F10</idno>
<idno type="wicri:doubleKey">0006-8993:1998:Boraud T:effects:of:l</idno>
<idno type="wicri:Area/Main/Merge">004728</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.</title>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
<affiliation wicri:level="3"><nlm:affiliation>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France. thomas.boraud@umr5543.u-bordeaux2.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Basal Gang, Lab. Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
</author>
</analytic>
<series><title level="j">Brain research</title>
<idno type="ISSN">0006-8993</idno>
<imprint><date when="1998" type="published">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Dopamine Agents (toxicity)</term>
<term>Female</term>
<term>Globus Pallidus (cytology)</term>
<term>Globus Pallidus (drug effects)</term>
<term>Immunohistochemistry</term>
<term>Levodopa (pharmacology)</term>
<term>MPTP Poisoning</term>
<term>Macaca mulatta</term>
<term>Neurons (drug effects)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (drug therapy)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Dopamine Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Globus Pallidus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Globus Pallidus</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Immunohistochemistry</term>
<term>MPTP Poisoning</term>
<term>Macaca mulatta</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004081 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004081 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:3759171F6694F1802E7557E0225516F539CAF014
   |texte=   Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri