ParkinsonFranceV1, Main, Merge, bibRecord, 004956

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Identifieur interne : 004956 ( Main/Merge ); précédent : 004955; suivant : 004957

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Auteurs : T. Boraud [France] ; E. Bezard [France] ; D. Guehl [France] ; B. Bioulac [France] ; C. Gross [France]

Source :

Brain research [ 0006-8993 ] ; 1998.

RBID : Pascal:98-0235202

Descripteurs français

Pascal (Inist)
- Dopa, Pallidum, Neurotoxine, Mode décharge, Traitement, Parkinson maladie, Chimiothérapie, Pathologie expérimentale, Animal, Singe, MPTP.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Animal, Chemotherapy, Discharge pattern, Dopa, Experimental disease, Monkey, Neurotoxin, Pallidum, Parkinson disease, Treatment.

Abstract

We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.

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Pascal:98-0235202

Le document en format XML

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<front><div type="abstract" xml:lang="en">We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri