Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Identifieur interne : 004861 ( Main/Merge ); précédent : 004860; suivant : 004862Effects of l-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Auteurs : Th Boraud [France] ; E. Bezard [France] ; D. Guehl [France] ; B. Bioulac [France] ; Ch Gross [France]Source :
- Brain Research [ 0006-8993 ] ; 1998.
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Abstract
We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.
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DOI: 10.1016/S0006-8993(97)01563-1
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ISTEX:3759171F6694F1802E7557E0225516F539CAF014Le document en format XML
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<front><div type="abstract" xml:lang="en">We studied the effects of l-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During l-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of l-DOPA on GPi output is limited.</div>
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