ParkinsonFranceV1, Main, Curation, bibRecord, 001654

Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease

Identifieur interne : 001654 ( Main/Curation ); précédent : 001653; suivant : 001655

Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease

Auteurs : Brigitte Piallat [France] ; Mircea Polosan [France] ; Valérie Fraix [France] ; Laurent Goetz [France] ; Olivier David [France] ; Albert Fenoy [France] ; Napoleon Torres [France] ; Jean-Louis Quesada [France] ; Eric Seigneuret [France] ; Pierre Pollak [France] ; Paul Krack [France] ; Thierry Bougerol [France] ; Alim L. Benabid [France] ; Stéphan Chabardès [France]

Source :

Annals of Neurology [ 0364-5134 ] ; 2011-05.

RBID : ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Obsession compulsion, Pathologie du système nerveux.

English descriptors

KwdEn :
- Action Potentials (physiology), Adult, Aged, Female, Functional Laterality (physiology), Humans, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Nervous system diseases, Neurons (physiology), Obsessive compulsive disorder, Obsessive-Compulsive Disorder (pathology), Parkinson Disease (pathology), Parkinson disease, Subthalamic Nucleus (pathology).
MESH :
- methods : Imaging, Three-Dimensional, Magnetic Resonance Imaging.
- pathology : Obsessive-Compulsive Disorder, Parkinson Disease, Subthalamic Nucleus.
- physiology : Action Potentials, Functional Laterality, Neurons.
- Adult, Aged, Female, Humans, Male, Middle Aged.

Abstract

Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.

Url:

DOI: 10.1002/ana.22222

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ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term>
<term>Adult</term>
<term>Aged</term>
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<term>Functional Laterality (physiology)</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neurons (physiology)</term>
<term>Obsessive compulsive disorder</term>
<term>Obsessive-Compulsive Disorder (pathology)</term>
<term>Parkinson Disease (pathology)</term>
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<front><div type="abstract">Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</div>
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<author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name>
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<author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name>
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<author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name>
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<author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
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<author><name sortKey="Quesada, Jean Louis" sort="Quesada, Jean Louis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name>
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<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name>
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<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardes">Stephan Chabardes</name>
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</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0237970</idno>
<date when="2011">2011</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease</title>
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</affiliation>
</author>
<author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name>
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</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name>
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<wicri:noRegion>Grenoble University</wicri:noRegion>
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<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name>
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<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardes">Stephan Chabardes</name>
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</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Obsessive compulsive disorder</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Obsession compulsion</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ±11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.</div>
</front>
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<author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroradiology, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Atomic Energy Commission of Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurosurgery, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Psychiatry, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Atomic Energy Commission of Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble University</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
<wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurosurgery, University Hospital of Grenoble</wicri:regionArea>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
<wicri:noRegion>University Hospital of Grenoble</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">France</country>
<wicri:regionArea>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Grenoble cédex 9</settlement>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-05">2011-05</date>
<biblScope unit="volume">69</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="793">793</biblScope>
<biblScope unit="page" to="802">802</biblScope>
</imprint>
<idno type="ISSN">0364-5134</idno>
</series>
<idno type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno>
<idno type="DOI">10.1002/ana.22222</idno>
<idno type="ArticleID">ANA22222</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term>
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Humans</term>
<term>Imaging, Three-Dimensional (methods)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurons (physiology)</term>
<term>Obsessive-Compulsive Disorder (pathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Subthalamic Nucleus (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term>
<term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term>
<term>Functional Laterality</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease

Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease

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