Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Identifieur interne : 000D61 ( Istex/Corpus ); précédent : 000D60; suivant : 000D62Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Auteurs : Brigitte Piallat ; Mircea Polosan ; Valérie Fraix ; Laurent Goetz ; Olivier David ; Albert Fenoy ; Napoleon Torres ; Jean-Louis Quesada ; Eric Seigneuret ; Pierre Pollak ; Paul Krack ; Thierry Bougerol ; Alim L. Benabid ; Stéphan ChabardèsSource :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Abstract
Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.
Url:
DOI: 10.1002/ana.22222
Links to Exploration step
ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name><affiliation><mods:affiliation>Atomic Energy Commission of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Atomic Energy Commission of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22222</idno><idno type="url">https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D61</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D61</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroradiology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name><affiliation><mods:affiliation>Atomic Energy Commission of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University Hospital of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Atomic Energy Commission of Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation><mods:affiliation>Grenoble University, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="793">793</biblScope><biblScope unit="page" to="802">802</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><idno type="DOI">10.1002/ana.22222</idno><idno type="ArticleID">ANA22222</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Brigitte Piallat PhD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string></affiliations></json:item><json:item><name>Mircea Polosan MD</name><affiliations><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Psychiatry, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Valérie Fraix MD, PhD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Neurology, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Laurent Goetz MSc</name><affiliations><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string></affiliations></json:item><json:item><name>Olivier David PhD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>Department of Neuroradiology, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Albert Fenoy MD</name><affiliations><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string></affiliations></json:item><json:item><name>Napoleon Torres MD, PhD</name><affiliations><json:string>Atomic Energy Commission of Grenoble, France</json:string></affiliations></json:item><json:item><name>Jean‐Louis Quesada MSc</name><affiliations><json:string>Grenoble University, France</json:string><json:string>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Eric Seigneuret MD</name><affiliations><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Neurosurgery, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Pierre Pollak MD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Neurology, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Paul Krack MD, PhD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Neurology, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Thierry Bougerol MD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>Department of Psychiatry, University Hospital of Grenoble, France</json:string></affiliations></json:item><json:item><name>Alim L. Benabid MD, PhD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>Atomic Energy Commission of Grenoble, France</json:string></affiliations></json:item><json:item><name>Stéphan Chabardès MD</name><affiliations><json:string>Grenoble University, France</json:string><json:string>INSERM‐U836, Grenoble Institute of Neurosciences, France</json:string><json:string>Department of Neurosurgery, University Hospital of Grenoble, France</json:string><json:string>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</json:string></affiliations></json:item></author><articleId><json:string>ANA22222</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.804</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 801 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>525</abstractCharCount><pdfWordCount>5086</pdfWordCount><pdfCharCount>33831</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>67</abstractWordCount></qualityIndicators><title>Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><refBibs><json:item><author><json:item><name>DJ. Stein</name></json:item></author><host><volume>360</volume><pages><last>405</last><first>397</first></pages><author></author><title>Lancet</title></host><title>Obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>S Thobois</name></json:item><json:item><name>E Jouanneau</name></json:item><json:item><name>M Bouvard</name></json:item><json:item><name>M. Sindou</name></json:item></author><host><volume>146</volume><pages><last>1031</last><first>1027</first></pages><author></author><title>Acta Neurochir (Wien)</title></host><title>Obsessive‐compulsive disorder after unilateral caudate nucleus bleeding</title></json:item><json:item><author><json:item><name>SR Cheyette</name></json:item><json:item><name>JL. Cummings</name></json:item></author><host><volume>7</volume><pages><last>134</last><first>125</first></pages><author></author><title>J Neuropsychiatry Clin Neurosci</title></host><title>Encephalitis lethargica: lessons for contemporary neuropsychiatry</title></json:item><json:item><author><json:item><name>S Saxena</name></json:item><json:item><name>SL. Rauch</name></json:item></author><host><volume>23</volume><pages><last>586</last><first>563</first></pages><author></author><title>Psychiatr Clin North Am</title></host><title>Functional neuroimaging and the neuroanatomy of obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>S Saxena</name></json:item><json:item><name>AL Brody</name></json:item><json:item><name>JM Schwartz</name></json:item><json:item><name>LR. Baxter</name></json:item></author><host><volume>(35)</volume><pages><last>37</last><first>26</first></pages><author></author><title>Br J Psychiatry Suppl</title></host><title>Neuroimaging and frontal‐subcortical circuitry in obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>LR Baxter Jr</name></json:item><json:item><name>JM Schwartz</name></json:item><json:item><name>KS Bergman</name></json:item></author><host><volume>49</volume><pages><last>689</last><first>681</first></pages><author></author><title>Arch Gen Psychiatry</title></host><title>Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>GE Alexander</name></json:item><json:item><name>MR DeLong</name></json:item><json:item><name>PL. Strick</name></json:item></author><host><volume>9</volume><pages><last>381</last><first>357</first></pages><author></author><title>Annu Rev Neurosci</title></host><title>Parallel organization of functionally segregated circuits linking basal ganglia and cortex</title></json:item><json:item><author><json:item><name>JL. Cummings</name></json:item></author><host><volume>50</volume><pages><last>880</last><first>873</first></pages><author></author><title>Arch Neurol</title></host><title>Frontal‐subcortical circuits and human behavior</title></json:item><json:item><author><json:item><name>P Krack</name></json:item><json:item><name>R Kumar</name></json:item><json:item><name>C Ardouin</name></json:item></author><host><volume>16</volume><pages><last>875</last><first>867</first></pages><author></author><title>Mov Disord</title></host><title>Mirthful laughter induced by subthalamic nucleus stimulation</title></json:item><json:item><author><json:item><name>A Parent</name></json:item><json:item><name>LN. Hazrati</name></json:item></author><host><volume>20</volume><pages><last>154</last><first>128</first></pages><author></author><title>II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res Brain Res Rev</title></host><title>Functional anatomy of the basal ganglia</title></json:item><json:item><author><json:item><name>DD Dougherty</name></json:item><json:item><name>L Baer</name></json:item><json:item><name>GR Cosgrove</name></json:item></author><host><volume>159</volume><pages><last>275</last><first>269</first></pages><author></author><title>Am J Psychiatry</title></host><title>Prospective long‐term follow‐up of 44 patients who received cingulotomy for treatment‐refractory obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>L Kihlstrom</name></json:item><json:item><name>T Hindmarsh</name></json:item><json:item><name>I Lax</name></json:item></author><host><volume>41</volume><pages><last>401</last><first>396</first></pages><author></author><title>Neurosurgery</title></host><title>Radiosurgical lesions in the normal human brain 17 years after gamma knife capsulotomy</title></json:item><json:item><author><json:item><name>B Nuttin</name></json:item><json:item><name>P Cosyns</name></json:item><json:item><name>H Demeulemeester</name></json:item></author><host><volume>354</volume><pages><first>1526</first></pages><author></author><title>Lancet</title></host><title>Electrical stimulation in anterior limbs of internal capsules in patients with obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>BD Greenberg</name></json:item><json:item><name>LH Price</name></json:item><json:item><name>SL Rauch</name></json:item></author><host><volume>14</volume><pages><last>212</last><first>199</first></pages><author></author><title>Neurosurg Clin North Am</title></host><title>Neurosurgery for intractable obsessive‐compulsive disorder and depression: critical issues</title></json:item><json:item><author><json:item><name>A Montoya</name></json:item><json:item><name>AP Weiss</name></json:item><json:item><name>BH Price</name></json:item></author><host><volume>50</volume><pages><last>1049</last><first>1043</first></pages><author></author><title>Neurosurgery</title></host><title>Magnetic resonance imaging‐guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease.</title></json:item><json:item><author><json:item><name>V Sturm</name></json:item><json:item><name>D Lenartz</name></json:item><json:item><name>A Koulousakis</name></json:item></author><host><volume>26</volume><pages><last>299</last><first>293</first></pages><author></author><title>J Chem Neuroanat</title></host><title>The nucleus accumbens: a target for deep brain stimulation in obsessive‐compulsive‐ and anxiety‐disorders</title></json:item><json:item><author><json:item><name>L Mallet</name></json:item><json:item><name>M Polosan</name></json:item><json:item><name>N Jaafari</name></json:item></author><host><volume>359</volume><pages><last>2134</last><first>2121</first></pages><author></author><title>N Engl J Med</title></host><title>Subthalamic nucleus stimulation in severe obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>AL Benabid</name></json:item><json:item><name>S Chabardes</name></json:item><json:item><name>J Mitrofanis</name></json:item><json:item><name>P. Pollak</name></json:item></author><host><volume>8</volume><pages><last>81</last><first>67</first></pages><author></author><title>Lancet Neurol</title></host><title>Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease</title></json:item><json:item><author><json:item><name>WD Hutchison</name></json:item><json:item><name>RJ Allan</name></json:item><json:item><name>H Opitz</name></json:item></author><host><volume>44</volume><pages><last>628</last><first>622</first></pages><author></author><title>Ann Neurol</title></host><title>Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease</title></json:item><json:item><author><json:item><name>CM Magarinos‐Ascone</name></json:item><json:item><name>R Figueiras‐Mendez</name></json:item><json:item><name>C Riva‐Meana</name></json:item><json:item><name>A. Cordoba‐Fernandez</name></json:item></author><host><volume>12</volume><pages><last>2607</last><first>2597</first></pages><author></author><title>Eur J Neurosci</title></host><title>Subthalamic neuron activity related to tremor and movement in Parkinson's disease</title></json:item><json:item><author><json:item><name>M Magnin</name></json:item><json:item><name>A Morel</name></json:item><json:item><name>D. Jeanmonod</name></json:item></author><host><volume>96</volume><pages><last>564</last><first>549</first></pages><author></author><title>Neuroscience</title></host><title>Single‐unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients</title></json:item><json:item><author><json:item><name>F Steigerwald</name></json:item><json:item><name>M Potter</name></json:item><json:item><name>J Herzog</name></json:item></author><host><volume>100</volume><pages><last>2524</last><first>2515</first></pages><author></author><title>J Neurophysiol</title></host><title>Neuronal activity of the human subthalamic nucleus in the parkinsonian and nonparkinsonian state</title></json:item><json:item><author><json:item><name>H Bergman</name></json:item><json:item><name>T Wichmann</name></json:item><json:item><name>B Karmon</name></json:item><json:item><name>MR. DeLong</name></json:item></author><host><volume>72</volume><pages><last>520</last><first>507</first></pages><author></author><title>II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol</title></host><title>The primate subthalamic nucleus</title></json:item><json:item><host><author></author><title>National Consultative Ethics Committee on Health and Life Sciences Opinion on functional neurosurgery for severe psychiatric disorder Number 71 2002‐04‐25.</title></host></json:item><json:item><author><json:item><name>WK Goodman</name></json:item><json:item><name>LH Price</name></json:item><json:item><name>SA Rasmussen</name></json:item></author><host><volume>46</volume><pages><last>1011</last><first>1006</first></pages><author></author><title>I. Development, use, and reliability. Arch Gen Psychiatry</title></host><title>The Yale‐Brown Obsessive Compulsive Scale</title></json:item><json:item><author><json:item><name>AL Benabid</name></json:item><json:item><name>PP Krack</name></json:item><json:item><name>A Benazzouz</name></json:item></author><host><volume>55</volume><pages><last>44</last><first>40</first></pages><author></author><title>Neurology</title></host><title>Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: methodologic aspects and clinical criteria</title></json:item><json:item><author><json:item><name>B Piallat</name></json:item><json:item><name>S Chabardes</name></json:item><json:item><name>N Torres</name></json:item></author><host><volume>158</volume><pages><last>1205</last><first>1201</first></pages><author></author><title>Neuroscience</title></host><title>Gait is associated with an increase in tonic firing of the sub‐cuneiform nucleus neurons</title></json:item><json:item><author><json:item><name>MG Murer</name></json:item><json:item><name>LA Riquelme</name></json:item><json:item><name>KY Tseng</name></json:item><json:item><name>JH. Pazo</name></json:item></author><host><volume>27</volume><pages><last>293</last><first>278</first></pages><author></author><title>Synapse</title></host><title>Substantia nigra pars reticulata single unit activity in normal and 60HDA‐lesioned rats: effects of intrastriatal apomorphine and subthalamic lesions</title></json:item><json:item><author><json:item><name>M. Abeles</name></json:item></author><host><volume>5</volume><pages><last>325</last><first>317</first></pages><author></author><title>J Neurosci Methods</title></host><title>Quantification, smoothing, and confidence limits for single‐units' histograms</title></json:item><json:item><author><json:item><name>A. Morel</name></json:item></author><host><author></author><title>New York, NY: Informa Healthcare USA,</title></host><title>Stereotactic atlas of the human thalamus and basal ganglia</title></json:item><json:item><author><json:item><name>R Levy</name></json:item><json:item><name>WD Hutchison</name></json:item><json:item><name>AM Lozano</name></json:item><json:item><name>JO. Dostrovsky</name></json:item></author><host><volume>20</volume><pages><last>7775</last><first>7766</first></pages><author></author><title>J Neurosci</title></host><title>High‐frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor</title></json:item><json:item><author><json:item><name>MC Rodriguez‐Oroz</name></json:item><json:item><name>M Rodriguez</name></json:item><json:item><name>J Guridi</name></json:item></author><host><volume>124</volume><pages><last>1790</last><first>1777</first></pages><author></author><title>Brain</title></host><title>The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics</title></json:item><json:item><author><json:item><name>T Wichmann</name></json:item><json:item><name>H Bergman</name></json:item><json:item><name>MR. DeLong</name></json:item></author><host><volume>72</volume><pages><last>506</last><first>494</first></pages><author></author><title>I. Functional properties in intact animals. J Neurophysiol</title></host><title>The primate subthalamic nucleus</title></json:item><json:item><author><json:item><name>GE Alexander</name></json:item><json:item><name>MD Crutcher</name></json:item><json:item><name>MR. DeLong</name></json:item></author><host><volume>85</volume><pages><last>146</last><first>119</first></pages><author></author><title>Prog Brain Res</title></host><title>Basal ganglia‐thalamocortical circuits: parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions</title></json:item><json:item><author><json:item><name>A Parent</name></json:item><json:item><name>Y. Smith</name></json:item></author><host><volume>436</volume><pages><last>310</last><first>296</first></pages><author></author><title>Brain Res</title></host><title>Organization of efferent projections of the subthalamic nucleus in the squirrel monkey as revealed by retrograde labeling methods</title></json:item><json:item><author><json:item><name>KH Monakow</name></json:item><json:item><name>K Akert</name></json:item><json:item><name>H. Kunzle</name></json:item></author><host><volume>33</volume><pages><last>403</last><first>395</first></pages><author></author><title>Exp Brain Res</title></host><title>Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey</title></json:item><json:item><author><json:item><name>MR DeLong</name></json:item><json:item><name>MD Crutcher</name></json:item><json:item><name>AP. Georgopoulos</name></json:item></author><host><volume>53</volume><pages><last>543</last><first>530</first></pages><author></author><title>J Neurophysiol</title></host><title>Primate globus pallidus and subthalamic nucleus: functional organization</title></json:item><json:item><author><json:item><name>M. Abeles</name></json:item></author><host><volume>304</volume><pages><last>524</last><first>523</first></pages><author></author><title>Time is precious. Science</title></host><title>Neuroscience</title></json:item><json:item><author><json:item><name>LR Baxter Jr</name></json:item><json:item><name>JM Schwartz</name></json:item><json:item><name>JC Mazziotta</name></json:item></author><host><volume>145</volume><pages><last>1563</last><first>1560</first></pages><author></author><title>Am J Psychiatry</title></host><title>Cerebral glucose metabolic rates in nondepressed patients with obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>V Molina</name></json:item><json:item><name>R Montz</name></json:item><json:item><name>M Martin‐Loeches</name></json:item></author><host><volume>36</volume><pages><last>2238</last><first>2234</first></pages><author></author><title>J Nucl Med</title></host><title>Drug therapy and cerebral perfusion in obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>TE Nordahl</name></json:item><json:item><name>C Benkelfat</name></json:item><json:item><name>WE Semple</name></json:item></author><host><volume>2</volume><pages><last>28</last><first>23</first></pages><author></author><title>Neuropsychopharmacology</title></host><title>Cerebral glucose metabolic rates in obsessive compulsive disorder</title></json:item><json:item><author><json:item><name>S Simpson</name></json:item><json:item><name>B. Baldwin</name></json:item></author><host><volume>166</volume><pages><last>392</last><first>390</first></pages><author></author><title>Br J Psychiatry</title></host><title>Neuropsychiatry and SPECT of an acute obsessive‐compulsive syndrome patient</title></json:item><json:item><author><json:item><name>AL Lacerda</name></json:item><json:item><name>P Dalgalarrondo</name></json:item><json:item><name>D Caetano</name></json:item></author><host><volume>123</volume><pages><last>134</last><first>125</first></pages><author></author><title>Psychiatry Res</title></host><title>Elevated thalamic and prefrontal regional cerebral blood flow in obsessive‐compulsive disorder: a SPECT study</title></json:item><json:item><author><json:item><name>SE Swedo</name></json:item><json:item><name>MB Schapiro</name></json:item><json:item><name>CL Grady</name></json:item></author><host><volume>46</volume><pages><last>523</last><first>518</first></pages><author></author><title>Arch Gen Psychiatry</title></host><title>Cerebral glucose metabolism in childhood‐onset obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>OA van den Heuvel</name></json:item><json:item><name>PL Remijnse</name></json:item><json:item><name>D Mataix‐Cols</name></json:item></author><host><volume>132</volume><pages><last>868</last><first>853</first></pages><author></author><title>Brain</title></host><title>The major symptom dimensions of obsessive‐compulsive disorder are mediated by partially distinct neural systems</title></json:item><json:item><host><volume>360</volume><pages><last>329</last><first>325</first></pages><author></author><title>The obsessive‐compulsive syndrome: reflection of fronto‐caudate dysregulation of the left hemisphere? [in French]. Encephale</title></host></json:item><json:item><author><json:item><name>D Guehl</name></json:item><json:item><name>A Benazzouz</name></json:item><json:item><name>B Aouizerate</name></json:item></author><host><volume>63</volume><pages><last>562</last><first>557</first></pages><author></author><title>Biol Psychiatry</title></host><title>Neuronal correlates of obsessions in the caudate nucleus</title></json:item><json:item><author><json:item><name>QJ Zhang</name></json:item><json:item><name>X Liu</name></json:item><json:item><name>J Liu</name></json:item></author><host><volume>1256</volume><pages><last>189</last><first>180</first></pages><author></author><title>Brain Res</title></host><title>Subthalamic neurons show increased firing to 5‐HT2C receptor activation in 6‐hydroxydopamine‐lesioned rats</title></json:item><json:item><author><json:item><name>E Dremencov</name></json:item><json:item><name>M El Mansari</name></json:item><json:item><name>P. Blier</name></json:item></author><host><volume>34</volume><pages><last>229</last><first>223</first></pages><author></author><title>J Psychiatry Neurosci</title></host><title>Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area</title></json:item><json:item><author><json:item><name>S Marceglia</name></json:item><json:item><name>S Mrakic‐Sposta</name></json:item><json:item><name>G Foffani</name></json:item></author><host><volume>24</volume><pages><last>3222</last><first>3213</first></pages><author></author><title>Eur J Neurosci</title></host><title>Gender‐related differences in the human subthalamic area: a local field potential study</title></json:item><json:item><author><json:item><name>B. Aouizerate</name></json:item></author><host><volume>57</volume><pages><last>63</last><first>59</first></pages><author></author><title>Rev Prat</title></host><title>Pathophysiological bases of obsessive‐compulsive disorder and therapeutic implications [in French]</title></json:item><json:item><author><json:item><name>AM Graybiel</name></json:item><json:item><name>SL. Rauch</name></json:item></author><host><volume>28</volume><pages><last>347</last><first>343</first></pages><author></author><title>Neuron</title></host><title>Toward a neurobiology of obsessive‐compulsive disorder</title></json:item><json:item><author><json:item><name>D Fontaine</name></json:item><json:item><name>V Mattei</name></json:item><json:item><name>M Borg</name></json:item></author><host><volume>100</volume><pages><last>1086</last><first>1084</first></pages><author></author><title>Case report. J Neurosurg</title></host><title>Effect of subthalamic nucleus stimulation on obsessive‐compulsive disorder in a patient with Parkinson disease</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>69</volume><publisherId><json:string>ANA</json:string></publisherId><pages><total>10</total><last>802</last><first>793</first></pages><issn><json:string>0364-5134</json:string></issn><issue>5</issue><subject><json:item><value>Original Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8249</json:string></eissn><title>Annals of Neurology</title><doi><json:string>10.1002/(ISSN)1531-8249</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/ana.22222</json:string></doi><id>D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</id><score>0.28591532</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2010 American Neurological Association</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><author xml:id="author-1"><persName><forename type="first">Brigitte</forename><surname>Piallat</surname></persName><roleName type="degree">PhD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Mircea</forename><surname>Polosan</surname></persName><roleName type="degree">MD</roleName><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Psychiatry, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Valérie</forename><surname>Fraix</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Laurent</forename><surname>Goetz</surname></persName><roleName type="degree">MSc</roleName><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Olivier</forename><surname>David</surname></persName><roleName type="degree">PhD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>Department of Neuroradiology, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Albert</forename><surname>Fenoy</surname></persName><roleName type="degree">MD</roleName><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation></author><author xml:id="author-7"><persName><forename type="first">Napoleon</forename><surname>Torres</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Atomic Energy Commission of Grenoble, France</affiliation></author><author xml:id="author-8"><persName><forename type="first">Jean‐Louis</forename><surname>Quesada</surname></persName><roleName type="degree">MSc</roleName><affiliation>Grenoble University, France</affiliation><affiliation>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-9"><persName><forename type="first">Eric</forename><surname>Seigneuret</surname></persName><roleName type="degree">MD</roleName><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-10"><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><roleName type="degree">MD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-11"><persName><forename type="first">Paul</forename><surname>Krack</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-12"><persName><forename type="first">Thierry</forename><surname>Bougerol</surname></persName><roleName type="degree">MD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>Department of Psychiatry, University Hospital of Grenoble, France</affiliation></author><author xml:id="author-13"><persName><forename type="first">Alim L.</forename><surname>Benabid</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>Atomic Energy Commission of Grenoble, France</affiliation></author><author xml:id="author-14"><persName><forename type="first">Stéphan</forename><surname>Chabardès</surname></persName><roleName type="degree">MD</roleName><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</affiliation><affiliation>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05"></date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="793">793</biblScope><biblScope unit="page" to="802">802</biblScope></imprint></monogr><idno type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><idno type="DOI">10.1002/ana.22222</idno><idno type="ArticleID">ANA22222</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</p></abstract><abstract><p>We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive‐compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation.</p></abstract><abstract><p>The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive‐compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left‐sided in obsessive‐compulsive disorder.</p></abstract><abstract><p>The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive‐compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left‐sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. Ann Neurol 2010.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-03-29">Received</change><change when="2010-08-06">Registration</change><change when="2011-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/ana.v69.5</doi><numberingGroup><numbering type="journalVolume" number="69">69</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2011-05">May 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="70" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ana.22222</doi><idGroup><id type="unit" value="ANA22222"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2010 American Neurological Association</copyright><eventGroup><event type="manuscriptReceived" date="2010-03-29"></event><event type="manuscriptRevised" date="2010-08-04"></event><event type="manuscriptAccepted" date="2010-08-06"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.8 mode:FullText" date="2011-04-22"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-12-28"></event><event type="firstOnline" date="2010-12-28"></event><event type="publishedOnlineFinalForm" date="2011-04-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">793</numbering><numbering type="pageLast">802</numbering></numberingGroup><correspondenceTo>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA22222.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="53"></count><count type="wordTotal" number="5959"></count></countGroup><titleGroup><title type="main" xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><title type="short" xml:lang="en">STN Firing in OCD and PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Brigitte</givenNames><familyName>Piallat</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Mircea</givenNames><familyName>Polosan</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2 #af4"><personName><givenNames>Valérie</givenNames><familyName>Fraix</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Laurent</givenNames><familyName>Goetz</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Olivier</givenNames><familyName>David</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Albert</givenNames><familyName>Fenoy</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Napoleon</givenNames><familyName>Torres</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af7"><personName><givenNames>Jean‐Louis</givenNames><familyName>Quesada</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2 #af6"><personName><givenNames>Eric</givenNames><familyName>Seigneuret</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1 #af2 #af4"><personName><givenNames>Pierre</givenNames><familyName>Pollak</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1 #af2 #af4"><personName><givenNames>Paul</givenNames><familyName>Krack</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Thierry</givenNames><familyName>Bougerol</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af1 #af8"><personName><givenNames>Alim L.</givenNames><familyName>Benabid</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af1 #af2 #af6" corresponding="yes"><personName><givenNames>Stéphan</givenNames><familyName>Chabardès</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="SChabardes@chu-grenoble.fr">SChabardes@chu‐grenoble.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Grenoble University, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Department of Psychiatry, University Hospital of Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurology, University Hospital of Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neuroradiology, University Hospital of Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurosurgery, University Hospital of Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="FR" type="organization"><unparsedAffiliation>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="FR" type="organization"><unparsedAffiliation>Atomic Energy Commission of Grenoble, France</unparsedAffiliation></affiliation></affiliationGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22222:ANA_22222_sm_suppinfo"></mediaResource><caption>Supporting Information.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22222:ANA_22222_sm_suppinfofigure_S1"></mediaResource><caption>Supporting Figure 1.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective</title><p>Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</p></section><section xml:id="abs1-2"><title type="main">Methods</title><p>We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive‐compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive‐compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, <i>p</i> < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left‐sided in obsessive‐compulsive disorder.</p></section><section xml:id="abs1-4"><title type="main">Interpretation</title><p>The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive‐compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left‐sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. Ann Neurol 2010.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STN Firing in OCD and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title></titleInfo><name type="personal"><namePart type="given">Brigitte</namePart><namePart type="family">Piallat</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mircea</namePart><namePart type="family">Polosan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Psychiatry, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valérie</namePart><namePart type="family">Fraix</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laurent</namePart><namePart type="family">Goetz</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olivier</namePart><namePart type="family">David</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>Department of Neuroradiology, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Albert</namePart><namePart type="family">Fenoy</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Napoleon</namePart><namePart type="family">Torres</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Atomic Energy Commission of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Louis</namePart><namePart type="family">Quesada</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Grenoble University, France</affiliation><affiliation>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric</namePart><namePart type="family">Seigneuret</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Krack</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurology, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thierry</namePart><namePart type="family">Bougerol</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>Department of Psychiatry, University Hospital of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim L.</namePart><namePart type="family">Benabid</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>Atomic Energy Commission of Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stéphan</namePart><namePart type="family">Chabardès</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Grenoble University, France</affiliation><affiliation>INSERM‐U836, Grenoble Institute of Neurosciences, France</affiliation><affiliation>Department of Neurosurgery, University Hospital of Grenoble, France</affiliation><affiliation>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-05</dateIssued><dateCaptured encoding="w3cdtf">2010-03-29</dateCaptured><dateValid encoding="w3cdtf">2010-08-06</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">3</extent><extent unit="references">53</extent><extent unit="words">5959</extent></physicalDescription><abstract>Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</abstract><abstract>We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive‐compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation.</abstract><abstract>The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive‐compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left‐sided in obsessive‐compulsive disorder.</abstract><abstract>The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive‐compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left‐sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. Ann Neurol 2010.</abstract><relatedItem type="host"><titleInfo><title>Annals of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information. - Supporting Figure 1. - </note><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>793</start><end>802</end><total>10</total></extent></part></relatedItem><identifier type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</identifier><identifier type="DOI">10.1002/ana.22222</identifier><identifier type="ArticleID">ANA22222</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D61 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000D61 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9
|texte= Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
}}
| This area was generated with Dilib version V0.6.29. |  |