Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Identifieur interne : 001735 ( Main/Merge ); précédent : 001734; suivant : 001736Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Auteurs : Brigitte Piallat [France] ; Mircea Polosan [France] ; Valérie Fraix [France] ; Laurent Goetz [France] ; Olivier David [France] ; Albert Fenoy [France] ; Napoleon Torres [France] ; Jean-Louis Quesada [France] ; Eric Seigneuret [France] ; Pierre Pollak [France] ; Paul Krack [France] ; Thierry Bougerol [France] ; Alim L. Benabid [France] ; Stéphan Chabardès [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
English descriptors
- KwdEn :
- Action Potentials (physiology), Adult, Aged, Female, Functional Laterality (physiology), Humans, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neurons (physiology), Obsessive-Compulsive Disorder (pathology), Parkinson Disease (pathology), Subthalamic Nucleus (pathology).
- MESH :
- methods : Imaging, Three-Dimensional, Magnetic Resonance Imaging.
- pathology : Obsessive-Compulsive Disorder, Parkinson Disease, Subthalamic Nucleus.
- physiology : Action Potentials, Functional Laterality, Neurons.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.
Url:
- https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00613111
DOI: 10.1002/ana.22222
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ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9Le document en format XML
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In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. 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<address> <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cea.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID"> <orgName>CHU Grenoble</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="U836" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Benabid, Alim" sort="Benabid, Alim" uniqKey="Benabid A" first="Alim" last="Benabid">Alim Benabid</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-40214" status="VALID"> <orgName>Laboratoire d'Electronique et des Technologies de l'Information</orgName> <orgName type="acronym">CEA-LETI</orgName> <date type="start">1967</date> <desc> <address> <addrLine>MINATEC 17, rue des Martyrs, 38054, Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www-leti.cea.fr/</ref> </desc> <listRelation> <relation active="#struct-302803" type="direct"></relation> <relation name="DRT/LETI" active="#struct-300016" type="direct"></relation> 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Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-390881" status="INCOMING"> <orgName>INSERM U836, équipe 11, Fonctions cérébrales et neuromodulation</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92131" type="direct"></relation> <relation active="#struct-300071" type="indirect"></relation> <relation active="#struct-51016" type="indirect"></relation> <relation active="#struct-86972" type="direct"></relation> <relation name="DSV/IRTSV" active="#struct-300016" type="indirect"></relation> <relation name="U836" active="#struct-303623" type="indirect"></relation> </listRelation><tutelles><tutelle active="#struct-92131" type="direct"><org type="laboratory" xml:id="struct-92131" status="VALID"> <orgName>Département de neurochirurgie</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-51016" type="direct"></relation> <relation active="#struct-300071" type="direct"></relation> </listRelation></org></tutelle><tutelle active="#struct-300071" type="indirect"><org type="institution" xml:id="struct-300071" status="VALID"> <orgName>CHU Grenoble</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-51016" type="indirect"><org type="institution" xml:id="struct-51016" status="OLD"> <idno type="IdRef">026404796</idno> <orgName>Université Joseph Fourier - Grenoble 1</orgName> <orgName type="acronym">UJF</orgName> <date type="end">2015-12-31</date> <desc> <address> <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ujf-grenoble.fr/</ref> </desc></org></tutelle><tutelle active="#struct-86972" type="direct"><org type="laboratory" xml:id="struct-86972" status="VALID"> <orgName>Grenoble Institut des Neurosciences</orgName> <orgName type="acronym">GIN</orgName> <desc> <address> <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref> </desc> <listRelation> <relation active="#struct-51016" type="direct"></relation> <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation> <relation active="#struct-300071" type="direct"></relation> <relation name="U836" active="#struct-303623" type="direct"></relation> </listRelation></org></tutelle><tutelle name="DSV/IRTSV" active="#struct-300016" type="indirect"><org type="institution" xml:id="struct-300016" status="VALID"> <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName> <orgName type="acronym">CEA</orgName> <desc> <address> <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cea.fr/</ref> </desc></org></tutelle><tutelle name="U836" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author></analytic><idno type="DOI">10.1002/ana.22222</idno><series><title level="j">Annals of Neurology</title><idno type="ISSN">0364-5134</idno><imprint><date type="datePub">2011-05</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. METHODS: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. RESULTS: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. INTERPRETATION: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.</div></front></TEI></HAL><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></author><author><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22222</idno><idno type="url">https://api.istex.fr/document/D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D61</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D61</idno><idno type="wicri:Area/Istex/Curation">000D59</idno><idno type="wicri:Area/Istex/Checkpoint">000309</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000309</idno><idno type="wicri:doubleKey">0364-5134:2011:Piallat B:subthalamic:neuronal:firing</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Atomic Energy Commission of Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Center of Clinical Investigation and INSERM‐003, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Atomic Energy Commission of Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Institut des Neurosciences, INSERM‐U836, Equipe 11, Université Joseph Fourier, Site Sante, La Tronche, BP170, 38042 Grenoble cédex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble cédex 9</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="793">793</biblScope><biblScope unit="page" to="802">802</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><idno type="DOI">10.1002/ana.22222</idno><idno type="ArticleID">ANA22222</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation wicri:level="1"><nlm:affiliation>Grenoble University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></author><author><name sortKey="Quesada, Jean Louis" sort="Quesada, Jean Louis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L" last="Benabid">Alim L. Benabid</name></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21520240</idno><idno type="pmid">21520240</idno><idno type="doi">10.1002/ana.22222</idno><idno type="wicri:Area/PubMed/Corpus">000974</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000974</idno><idno type="wicri:Area/PubMed/Curation">000934</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000934</idno><idno type="wicri:Area/PubMed/Checkpoint">000934</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000934</idno><idno type="wicri:Area/Ncbi/Merge">000D09</idno><idno type="wicri:Area/Ncbi/Curation">000D09</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation wicri:level="1"><nlm:affiliation>Grenoble University, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation></author><author><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name></author><author><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name></author><author><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></author><author><name sortKey="Quesada, Jean Louis" sort="Quesada, Jean Louis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name></author><author><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L" last="Benabid">Alim L. Benabid</name></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="eISSN">1531-8249</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term><term>Adult</term><term>Aged</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Imaging, Three-Dimensional (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Neurons (physiology)</term><term>Obsessive-Compulsive Disorder (pathology)</term><term>Parkinson Disease (pathology)</term><term>Subthalamic Nucleus (pathology)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term><term>Functional Laterality</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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