Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease
Identifieur interne : 000402 ( PascalFrancis/Corpus ); précédent : 000401; suivant : 000403Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease
Auteurs : Brigitte Piallat ; Mircea Polosan ; Valérie Fraix ; Laurent Goetz ; Olivier David ; Albert Fenoy ; Napoleon Torres ; Jean-Louis Quesada ; Eric Seigneuret ; Pierre Pollak ; Paul Krack ; Thierry Bougerol ; Alim L. Benabid ; Stephan ChabardesSource :
- Annals of neurology [ 0364-5134 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ±11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.
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Format Inist (serveur)
NO : | PASCAL 11-0237970 INIST |
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ET : | Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease |
AU : | PIALLAT (Brigitte); POLOSAN (Mircea); FRAIX (Valérie); GOETZ (Laurent); DAVID (Olivier); FENOY (Albert); TORRES (Napoleon); QUESADA (Jean-Louis); SEIGNEURET (Eric); POLLAK (Pierre); KRACK (Paul); BOUGEROL (Thierry); BENABID (Alim L.); CHABARDES (Stephan) |
AF : | Grenoble University/France (1 aut., 3 aut., 5 aut., 8 aut., 10 aut., 11 aut., 12 aut., 13 aut., 14 aut.); INSERM-U836, Grenoble Institute of Neurosciences/France (1 aut., 2 aut., 3 aut., 4 aut., 6 aut., 9 aut., 10 aut., 11 aut., 14 aut.); Department of Psychiatry, University Hospital of Grenoble/France (2 aut., 12 aut.); Department of Neurology, University Hospital of Grenoble/France (3 aut., 10 aut., 11 aut.); Department of Neuroradiology, University Hospital of Grenoble/France (5 aut.); Department of Neurosurgery, University Hospital of Grenoble/France (9 aut., 14 aut.); Center of Clinical Investigation and INSERM-003, University Hospital of Grenoble/France (8 aut.); Atomic Energy Commission of Grenoble/France (7 aut., 13 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2011; Vol. 69; No. 5; Pp. 793-802; Bibl. 53 ref. |
LA : | Anglais |
EA : | Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ±11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. |
CC : | 002B17; 002B17G |
FD : | Obsession compulsion; Maladie de Parkinson; Pathologie du système nerveux |
FG : | Trouble anxieux; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Obsessive compulsive disorder; Parkinson disease; Nervous system diseases |
EG : | Anxiety disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Obsesión compulsión; Parkinson enfermedad; Sistema nervioso patología |
LO : | INIST-16555.354000191534290040 |
ID : | 11-0237970 |
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Pascal:11-0237970Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease</title>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name>
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<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name>
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<author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardes">Stephan Chabardes</name>
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<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2011">2011</date>
</imprint>
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<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Obsessive compulsive disorder</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Obsession compulsion</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ±11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease</s1>
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<fA11 i1="01" i2="1"><s1>PIALLAT (Brigitte)</s1>
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<fA11 i1="02" i2="1"><s1>POLOSAN (Mircea)</s1>
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<server><NO>PASCAL 11-0237970 INIST</NO>
<ET>Subthalamic Neuronal Firing in Obsessive- Compulsive Disorder and Parkinson Disease</ET>
<AU>PIALLAT (Brigitte); POLOSAN (Mircea); FRAIX (Valérie); GOETZ (Laurent); DAVID (Olivier); FENOY (Albert); TORRES (Napoleon); QUESADA (Jean-Louis); SEIGNEURET (Eric); POLLAK (Pierre); KRACK (Paul); BOUGEROL (Thierry); BENABID (Alim L.); CHABARDES (Stephan)</AU>
<AF>Grenoble University/France (1 aut., 3 aut., 5 aut., 8 aut., 10 aut., 11 aut., 12 aut., 13 aut., 14 aut.); INSERM-U836, Grenoble Institute of Neurosciences/France (1 aut., 2 aut., 3 aut., 4 aut., 6 aut., 9 aut., 10 aut., 11 aut., 14 aut.); Department of Psychiatry, University Hospital of Grenoble/France (2 aut., 12 aut.); Department of Neurology, University Hospital of Grenoble/France (3 aut., 10 aut., 11 aut.); Department of Neuroradiology, University Hospital of Grenoble/France (5 aut.); Department of Neurosurgery, University Hospital of Grenoble/France (9 aut., 14 aut.); Center of Clinical Investigation and INSERM-003, University Hospital of Grenoble/France (8 aut.); Atomic Energy Commission of Grenoble/France (7 aut., 13 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2011; Vol. 69; No. 5; Pp. 793-802; Bibl. 53 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive-compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive-compulsive disorder than in patients with Parkinson disease (20.5 ±11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left-sided in obsessive-compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive-compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left-sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops.</EA>
<CC>002B17; 002B17G</CC>
<FD>Obsession compulsion; Maladie de Parkinson; Pathologie du système nerveux</FD>
<FG>Trouble anxieux; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Obsessive compulsive disorder; Parkinson disease; Nervous system diseases</ED>
<EG>Anxiety disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Obsesión compulsión; Parkinson enfermedad; Sistema nervioso patología</SD>
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